Wei Cao

Department of Immunology

Univ. of Texas M.D. Anderson Cancer Center, USA

Email: [email protected]

Qualifications
1999 Postdoctoral Fellow, Molecular Virology & Immunology, Scripps Research Institute, USA

1995 Ph.D., Biochemistry, University of North Carolina at Chapel Hill, USA

1991 Bachelor of Science, Biology, Tsinghua University, Beijing, China

Publications (selected)

1. Roy, Ethan & Wang, Qiang & Huang, Kexin & Li, Sanming & Fan, Yuanyuan & Escobar, Estrella & Huang, Shuning & Herrera, Juan & Li, Wenbo & Pridans, Clare & Zhou, Xiaobo & Ju, Cynthia & Cao, Wei. (2025). Non-mutated human tau stimulates Alzheimer's disease-relevant neurodegeneration in a microglia-dependent manner. bioRxiv : the preprint server for biology. 10.1101/2025.01.10.632400.

2. Roy, Ethan & Li, Sanming & Saroukhani, Sepideh & Wang, Yanyu & Cao, Wei. (2024). Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging. Molecular neurodegeneration. 19. 48. 10.1186/s13024-024-00736-6.

3. Roy, Ethan & Li, Sanming & Wang, Yanyu & Cao, Wei. (2024). Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging. bioRxiv : the preprint server for biology. 10.1101/2024.05.20.595027.

4. Cao, Wei. (2024). In sickness and in health-Type I interferon and the brain. Frontiers in aging neuroscience. 16. 1403142. 10.3389/fnagi.2024.1403142.

5. Ravel-Godreuil, Camille & Roy, Ethan & Puttapaka, Srinivas & Li, Sanming & Wang, Yanyu & Yuan, Xiaoyi & Eltzschig, Holger & Cao, Wei. (2024). Transcriptional Responses of Different Brain Cell Types to Oxygen Decline. Brain Sciences. 14. 341. 10.3390/brainsci14040341.                                                 

6. Li, Sanming & Roy, Ethan & Watkins, Trent & Cao, Wei. (2023). Modeling Alzheimer’s Disease: DNA damage response and MAPK‐DLK signaling in wild‐type tau‐induced neurodegeneration. Alzheimer's & Dementia. 19. 10.1002/alz.078025.

7. Li, Sanming & Roy, Ethan & Wang, Yanyu & Watkins, Trent & Cao, Wei. (2023). DLK-MAPK Signaling Coupled with DNA Damage Promotes Intrinsic Neurotoxicity Associated with Non-Mutated Tau. Molecular Neurobiology. 61. 1-18. 10.1007/s12035-023-03720-1.                    

8. Li, Sanming & Roy, Ethan & Wang, Yanyu & Watkins, Trent & Cao, Wei. (2023). Modeling Alzheimer’s disease in primary neurons reveals DNA damage response coupled with MAPK-DLK signaling in wild-type tau-induced neurodegeneration. Research square. 10.21203/rs.3.rs-2617457/v1.

9. Roy, Ethan & Cao, Wei. (2022). Glial interference: impact of type I interferon in neurodegenerative diseases. Molecular neurodegeneration. 17. 78. 10.1186/s13024-022-00583-3.                                  

10. Zhao, Peng & Xu, Yuanzhong & Jiang, LuLin & Fan, Xuejun & Li, Leike & Li, Xin & Arase, Hisashi & Zhao, Yingjun & Cao, Wei & Zheng, Hui & Xu, Huaxi & Tong, Qingchun & Zhang, Ningyan & An, Zhiqiang. (2022). A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease. Science Translational Medicine. 14. 10.1126/scitranslmed.abq0095.

11. Cao, Wei. (2022). IFN-Aging: Coupling Aging With Interferon Response. Frontiers in Aging. 3. 870489. 10.3389/fragi.2022.870489.

12. Roy, Ethan & Chiu, Gabriel & Li, Sanming & Propson, Nicholas & Kanchi, Rupa & Wang, Baiping & Coarfa, Cristian & Zheng, Hui & Cao, Wei. (2022). Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques. Immunity. 55. 10.1016/j.immuni.2022.03.018.

13. Roy, Ethan & Chiu, Gabriel & Li, Sanming & Zheng, Hui & Cao, Wei. (2021). Concerted cellular responses to type I interferon propel memory impairment associated with amyloid β plaques. Alzheimer's & dementia : the journal of the Alzheimer's Association. 17 Suppl 3. e057524. 10.1002/alz.057524.

14. Roy, Ethan & Chiu, Gabriel & Li, Sanming & Propson, Nicholas & Zheng, Hui & Cao, Wei. (2021). Concerted cellular responses to type I interferon propel memory impairment associated with amyloid β plaques. 10.1101/2021.11.01.466525.

15. Ramirez, Paulino & Zuniga, Gabrielle & Sun, Wenyan & Beckmann, Adrian & Ochoa, Elizabeth & Devos, Sarah & Hyman, Bradley & Chiu, Gabriel & Roy, Ethan & Cao, Wei & Orr, Miranda & Buggia-Prevot, Virginie & Ray, William & Frost, Bess. (2021). Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system. Progress in Neurobiology. 208. 102181. 10.1016/j.pneurobio.2021.102181.

16. Ramirez, Paulino & Sun, Wenyan & Zuniga, Gabrielle & Ochoa, Elizabeth & Devos, Sarah & Hyman, Bradley & Chiu, Gabriel & Roy, Ethan & Cao, Wei & Orr, Miranda & Buggia-Prevot, Virginie & Ray, William & Frost, Bess. (2021). Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system. 10.1101/2021.02.25.432716.

17. Roy, Ethan & Cao, Wei. (2020). Antiviral Immune Response in Alzheimer’s Disease: Connecting the Dots. Frontiers in Neuroscience. 14. 10.3389/fnins.2020.577744.

18. Roy, Ethan & Wang, Baiping & Wan, Ying-Wooi & Chiu, Gabriel & Cole, Allysa & Yin, Zhuoran & Propson, Nicholas & Xu, Yin & Jankowsky, Joanna & Liu, Zhandong & Lee, Virginia & Trojanowski, John & Ginsberg, Stephen & Butovsky, Oleg & Zheng, Hui & Cao, Wei. (2020). Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease. Journal of Clinical Investigation. 130. 10.1172/JCI133737.                                                     

19. Propson, Nicholas & Litvinchuk, Alexandra & Roy, Ethan & Contreras, Bianca & Cao, Wei & Zheng, Hui. (2019). INCREASED C3 IN THE AGING BRAIN PROMOTES INFLAMMATORY TRANSITION IN ENDOTHELIAL CELLS. Innovation in Aging. 3. S840-S840. 10.1093/geroni/igz038.3093.

20. Roy, Ethan & Wang, Baiping & Zheng, Hui & Cao, Wei. (2019). TYPE I INTERFERON-MEDIATED NEUROINFLAMMATORY PROGRAM AND SYNAPSE LOSS IN ALZHEIMER’S DISEASE. Innovation in Aging. 3. S92-S92. 10.1093/geroni/igz038.349.

Profile Details

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