Prof. Wan-Fai Ng

Faculty of Medical Sciences

Newcastle University, UK

E-mail: [email protected]

Qualifications

2010    FRCP, Royal College of Physicians, London

2006    CCT (Rheumatology), Postgraduate Medical Education & Training Board, UK
2003    Ph.D., Immunology, Imperial College, London
1997    MRCP, Royal College of Physicians, London
1995    M.B., Neurology Prize, University of Cambridge, UK
1992    B.A., Pathology, University of Cambridge, UK

Publications (selected)

1. Snoeck Henkemans, Selinde & Biggelaar, Anne-Fleur & van Mulligen, Elise & Bergstra, Sytske Anne & Luime, Jolanda & Kok, Marc & Tchetverikov, Ilja & Oosterhout, Maikel & Kaap, Jos & Ng, Wan-Fai & Vis, Marijn & de Jong, Pascal H.P.. (2025). Rheumatoid arthritis and psoriatic arthritis: is the disease impact different? A large matching study at diagnosis and after 1 year of treatment. RMD Open. 11. e005143. 10.1136/rmdopen-2024-005143.

2. Heutz, Judith & Boeren, Anna & Claassen, Stijn & Mulligen, Elise & de Jong, Pascal H.P. & Ng, Wan-Fai. (2025). Shorter reproductive time span and early menopause increase the risk of ACPA-negative inflammatory arthritis in postmenopausal women with clinically suspect arthralgia. Rheumatology (Oxford, England). 10.1093/rheumatology/keaf083.

3. Griethuysen, Simonetta & Dumoulin, Quirine & van Mulligen, Elise & Ng, Wan-Fai. (2025). Can treatment expectations or treatment itself in patients with arthralgia suspicious for progression to rheumatoid arthritis improve illness perceptions?. Rheumatology (Oxford, England). 10.1093/rheumatology/keaf095.

4. Grader-Beck, Thomas & Fisher, Benjamin & Mariette, Xavier & Papas, Athena & Bootsma, Hendrika & Ng, Wan-Fai & Daele, P.L.A. & Finzel, Stephanie & Elgueta, Sergio & Hermann, Josef & Mccoy, Sara & Bookman, Arthur & Sopala, Monika & Luo, Wen-Lin & Scheurer, Cornelia & Hueber, Wolfgang. (2025). Iscalimab (CFZ533) in patients with Sjögren disease: week 24 efficacy and safety results of a randomized, placebo-controlled, phase 2b dose-ranging study. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 139. e50. 10.1016/j.oooo.2024.10.096.

5. Demirkan, Ayse & Dongen, Jenny & Finnicum, Casey & Ng, Wan-Fai & Medema-Jankipersadsing, Soesma & Willemsen, Gonneke & Ijzerman, Richard & Boomsma, Dorret & Ehli, Erik & Bonder, Marc Jan & Fu, Jingyuan & Franke, Lude & Wijmenga, Cisca & Geus, Eco & Kurilshikov, Alexander & Zhernakova, Alexandra. (2024). Linking the gut microbiome to host DNA methylation by a discovery and replication epigenome-wide association study. BMC Genomics. 25. 10.1186/s12864-024-11136-x.                                                       

6. Boeren, Anna & Ton, Dennis & van Mulligen, Elise & Klerk, Bianca & de Jong, Pascal H.P. & Oei, Edwin & Reijnierse, Monique & Ng, Wan-Fai. (2024). A simplified fluid-sensitive MRI protocol for the hands to detect inflammation without contrast administration: a large study of symptom-free subjects from the general population as a reference for normality. Skeletal radiology. 10.1007/s00256-024-04843-9.

7. Bakker, Olivier & Claringbould, Annique & Ng, Wan-Fai & Wiersma, Henry & Boulogne, Floranne & Võsa, Urmo & Urzúa-Traslaviña, Carlos & Mulcahy Symmons, Sophie & Zidan, Mahmoud & Sadler, Marie & Kutalik, Zoltan & Jonkers, Iris & Franke, Lude & Deelen, Patrick. (2024). Identification of rare disease genes as drivers of common diseases through tissue-specific gene regulatory networks. Scientific Reports. 14. 10.1038/s41598-024-80670-1.                          

8. Heutz, Judith & de Jong, Pascal H.P. & Verstappen, Marloes & Ng, Wan-Fai & van Mulligen, Elise. (2024). Sustained DMARD-free remission in subgroups of patients with rheumatoid arthritis: an analysis of two prospective cohorts with early arthritis. The Lancet Rheumatology. 10.1016/S2665-9913(24)00234-0.

9. Berry, Joe & Tarn, Jessica & Casement, John & Lendrem, Dennis & Thompson, Kyle & Mariette, Xavier & Gottenberg, Jacques-Eric & Ng, Wan-Fai. (2024). Stability of symptom-based subtypes in Sjogren’s disease. RMD Open. 10. 10.1136/rmdopen-2024-004914.

10. Claassen, Stijn & Boeren, Anna & Khidir, Sarah & Steenbergen, Hanna & Ng, Wan-Fai. (2024). Is rheumatoid arthritis always preceded by a symptomatic at-risk phase of arthralgia?. RMD Open. 10. e004714. 10.1136/rmdopen-2024-004714.

11. Snoeck Henkemans, Selinde & Vis, Marijn & Koc, Gonul Hazal & Luime, Jolanda & Kok, Marc & Tchetverikov, Ilja & Kooij, Sjoerd & Bijsterbosch, Jessica & Ng, Wan-Fai & de Jong, Pascal H.P.. (2024). Association between depression and anxiety and inability to achieve remission in rheumatoid arthritis and psoriatic arthritis. Rheumatology (Oxford, England). 10.1093/rheumatology/keae621.

12. Looijen, Agnes & Snoeck Henkemans, Selinde & Ng, Wan-Fai & Welsing, Paco & Koc, Gonul Hazal & Luime, Jolanda & Kok, Marc & Tchetverikov, Ilja & Korswagen, Lindy-Anne & Baudoin, Paul & Vis, Marijn & de Jong, Pascal H.P.. (2024). Combining patient-reported outcome measures to screen for active disease in rheumatoid arthritis and psoriatic arthritis. RMD Open. 10. e004687. 10.1136/rmdopen-2024-004687.

13. Dumoulin, Quirine & Krijbolder, Doortje & Visser, Karen & Lard, Leroy & Ng, Wan-Fai. (2024). Development of rheumatoid arthritis after methotrexate in anticitrullinated protein antibody-negative people with clinically suspect arthralgia at risk of rheumatoid arthritis: 4-year data from the TREAT EARLIER trial. The Lancet Rheumatology. 6. 10.1016/S2665-9913(24)00196-6.

14. Wu, Jiafei & Palasantzas, Victoria & Andreu-Sánchez, Sergio & Plösch, Torsten & Leonard, Sam & Li, Shuang & Bonder, Marc Jan & Ng, Wan-Fai & Meurs, Joyce & Ghanbari, Mohsen & Franke, Lude & Zhernakova, Alexandra & Fu, Jingyuan & Hoogerland, Joanne & Zhernakova, Daria. (2024). Epigenome-wide association study on the plasma metabolome suggests self-regulation of the glycine and serine pathway through DNA methylation. Clinical Epigenetics. 16. 10.1186/s13148-024-01718-7.

15. Heutz, Judith & Looijen, Agnes & Ng, Wan-Fai & de Jong, Pascal H.P. & van Mulligen, Elise. (2024). Tapering csDMARD or TNFi first: is the risk of flares different for ACPA-positive or ACPA-negative rheumatoid arthritis?. RMD Open. 10. e004258. 10.1136/rmdopen-2024-004258.

16. Urzúa-Traslaviña, Carlos & Lieshout, Tijs & Boulogne, Floranne & Domanegg, Kevin & Zidan, Mahmoud & Bakker, Olivier & Claringbould, Annique & Ridder, Jeroen & Zwart, Wilbert & Ng, Wan-Fai & Deelen, Patrick & Franke, Lude. (2024). Co-expression in tissue-specific gene networks links genes in cancer-susceptibility loci to known somatic driver genes. BMC Medical Genomics. 17. 10.1186/s12920-024-01941-4.

17. Heutz, Judith & Looijen, Agnes & Kuijpers, Jac & Schreurs, Marco & Ng, Wan-Fai & Jong, Pascal. (2024). The prognostic value of IgA anti-citrullinated protein antibodies and rheumatoid factor in an early arthritis population with a treat-to-target approach. Immunologic Research. 72. 982-990. 10.1007/s12026-024-09500-w.

18. Li, Yanli & Hassanzadeh, Tahereh & Shamonin, Denis & Reijnierse, Monique & Ng, Wan-Fai & Stoel, Berend. (2024). Integrated feature analysis for deep learning interpretation and class activation maps. 10.48550/arXiv.2407.01142.                                                            

19. Fisher, Benjamin & Mariette, Xavier & Papas, Athena & Grader-Beck, Thomas & Bootsma, Hendrika & Ng, Wan-Fai & Daele, P & Finzel, Stephanie & Noaiseh, Ghaith & Elgueta, Sergio & Hermann, Josef & Mccoy, Sara & Akpek, Esen & Bookman, Arthur & Sopala, Monika & Montecchi-Palmer, Michela & Luo, Wen-Lin & Scheurer, Cornelia & Hueber, Wolfgang & Sandorfi, Nora. (2024). Safety and efficacy of subcutaneous iscalimab (CFZ533) in two distinct populations of patients with Sjögren's disease (TWINSS): week 24 results of a randomised, double-blind, placebo-controlled, phase 2b dose-ranging study. The Lancet. 404. 10.1016/S0140-6736(24)01211-X.

20. Boeren, Anna & Oei, Edwin & Willemze, Annemiek & de Jong, Pascal H.P. & Ng, Wan-Fai & van Mulligen, Elise. (2024). Ultrasound of the forefeet besides the hands in patients at risk for rheumatoid arthritis: is it worth the effort? A longitudinal cohort study. Rheumatology (Oxford, England). 10.1093/rheumatology/keae339.

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