Prof. Hwei-Fang Tien

Department of Internal Medicine,

National Taiwan University Hospital, Taiwan

E-mail: [email protected]

Qualifications

Fellow, Cytogenetic Oncology, National Cancer Institute, USA

Fellow, Division of Hematology, VA Medical Center, University of Louisville, USA

Ph.D., Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, China

M.D., College of Medicine, National Taiwan University, China

Publications (selected)

1. Shih TTF, Hou HA, Liu CY, Chen BB, Tang JL, Chen HY, Wei SY, Yao M, Huang SY, Chou WC, Hsu SC, Tsay W, Yu CW, Hsu CY, Tien HF* Yang PC: Bone marrow angiogenesis MR imaging in patients with acute myeloid leukemia: Peak enhancement ratio is an independent predictor for overall survival. Blood 113: 3161-3167, 2009.
2. Chou WC, Chen CY, Hou HA, Lin LI, Tang JL, Yao M, Tsay W, Ko BS, Wu SJ, Huang SY, Hsu SC, Chen YC, Huang YN, Tseng MH, Huang CF, Tien HF*: Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: Comparative analysis of 493 adult patients. Leukemia 23:1303-1310, 2009.
3. Tang JL, Hou HA, Chen CY, Liu CY, Chou WC, Tseng MH, Huang CF, Lee FY, Liu MC, Yao M, Huang SY, Ko BS, Hsu SC, Wu SJ, Tsay W, Chen YC, Lin LI, Tien HF*: AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations. Blood 114: 5352-5361, 2009.
4. Chou WC, Hou HA, Chen CY, Tang JL, Yao M, Tsay W, Ko BS, Wu SJ, Huang SY, Hsu SC, Chen YC, Huang YN, Chang YC, Lee FY, Liu MC, Liu CW, Tseng MH, Huang CF, Tien HF*: Distinct clinical and biological characteristics in adult acute myeloid leukemia bearing isocitrate dehydrogenase 1 (IDH1) mutation. Blood 115: 2749-2754, 2010.
5. Hou HA, Huang TC, Lin LI, Liu CY, Chen CY, Chou WC, Tang JL, Tseng MH, Huang CF, Chiang YC, Lee FY, Liu MC, Yao M, Huang SY, Ko BS, Hsu SC, Wu SJ, Tsay W, Chen YC, Tien HF*: WT1 mutation in 470 adult patients with acute myeloid leukemia: stability during disease evolution and implication of its incorporation into a survival scoring system. Blood 115: 5222-5231, 2010.
6. Chou WC, Huang YN, Huang CF, Tseng MH, Tien HF*: A single-tube, sensitive multiplex method for screening of isocitrate dehydrogenase 1 (IDH1) mutations. Blood 116: 495-496, 2010.
7. Hou HA, Shih TTF, Liu CY, Chen BB, Tang JL, Yao M, Huang SY, Chou WC, Hsu CY, Tien HF* : Changes in magnetic resonance bone marrow angiogenesis on day 7 after Induction chemotherapy can predict outcome of acute myeloid leukemia. Haematologica 95: 1420-1424, 2010.
8. Chou WC, Huang HH, Hou HA, Chen CY, Tang JL, Yao M, Tsay W, Ko BS, Wu SJ, Huang SY, Hsu SC, Chen YC, Huang YN, Chang YC, Lee FU, Liu MC, Liu CW, Tseng MH, Huang CF, Tien HF* : Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations. Blood 116: 4086-4094, 2010.
9. Wu SJ, Huang SY, Lin CT, Lin YJ, Chang CJ, Tien HF* : The incidence of chronic lymphocytic leukemia in Taiwan,1986-2005: A distinct increasing trend with birth-cohort effect. Blood 116: 4430-4435, 2010.
10. Lin TC, Hou HA, Chou WC, Ou DL, Yu SL, Tien HF*, Lin LI: CEBPA methylation as a prognostic biomarker in patients with de novo acute myeloid leukemia. Leukemia 25: 32-40, 2011.
11. Chou WC, Lei WC, Ko BS, Hou HA, Chen CY, Tang JL, Yao M, Tsay W, Wu SJ, Huang SY, Hsu SC, Chen YC, Chang YC, Kuo KT, Lee FY, Liu MC, Liu CW, Tseng MH, Huang CF, Tien HF*: The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia. Leukemia 25: 246-253, 2011.
12. Chou WC, Hou HA, Liu CY, Chen CY, Lin LI, Huang YN, Chao YC, Hsu CA, Huang CF, Tien HF*: Sensitive measurement of quantity dynamics of FLT3 internal tandem duplication at early time points provides prognostic information. Ann Oncol 22: 696-704, 2011.
13. Cheng CL, Hou HA, Jhuang JY, Lin CW, Chen CY, Tang JL, Chou WC, Tseng MH, Yao M, Huang SY, Ko BS, Hsu SC, Wu SJ, Tsay W, Chen YC, Tien HF*: High bone marrow angiopoietin-1 expression is an independent poor prognostic factor for survival in patients with myelodysplastic syndromes. Br J Cancer 105: 975-982, 2011.
14. Chou WC, Chou SC, Liu CY, Chen CY, Hou HA, Kuo YY, Lee MC, Ko BS, Tang JL, Yao M, Tsay W, Wu SJ, Huang SY, Hsu SC, Chen YC, Chang YC, Kuo YY, Kuo KT, Lee FY, Liu MC, Liu CW, Tseng MH, Huang CF, Tien HF*: TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics. Blood 118: 3803-3810, 2011.
15. Hou HA, Kuo YY, Liu CY, Lee MC, Tang JL, Chen CY, Chou WC, Huang CF, Lee FY, Liu MC, Yao M, Tien HF*: Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia. Br J Cancer 105: 1927-1933, 2011
16. Hou HA, Kuo YY, Liu CY, Chou WC, Lee MC, Chen CY, Lin LI, Tseng MH, Huang CF, Chiang YC, Lee FY, Liu MC, Liu CW, Tang JL, Yao M, Huang SY, Ko BS, Hsu SC, Wu SJ, Tsay W, Chen YC, Tien HF*: DNMT3A mutations in acute myeloid leukemia-stability during disease evolution and the clinical implication. Blood 119: 559-568, 2012.
17. Chou WC, Peng KY, Lei WC, Ko BS, Tsay W, Kuo CH, Tien HF*: Persistence of mutant isocitrate dehydrogenase in patients with acute myeloid leukemia in remission. Leukemia, 2012, in press.