Dr. Yiru Xu

Department of Dermatology

University of Michigan Medical School, USA

Associate Professor

Email: [email protected]

Qualifications

1998 Postdoc Training, Dept. of Biochemistry, Vanderbilt University, USA

1995 Ph.D., Dept. of Microbiology, Medical College of Wisconsin, USA

1989 B.Sc., Dept. of Biochemistry, Fudan University, China

Publications (selected)

1. Sun, M., Wang, P., & Sachs, D., et al. (2016). Topical retinol restores type I collagen production in photoaged forearm skin within four weeks. Cosmetics, 3(4), Article 40.
2. Wang, P., Sun, M., & Xu, Y., et al. (2016). Once weekly topical all-trans retinol restores type I collagen synthesis in photoaged forearm skin within 4 weeks: A protocol for evaluating anti-aging topical agents. Journal of Investigative Dermatology, 136(5), S47.
3. Xu, Y., Yang, H., & Xu, Y., et al. (2015). Down-regulation of receptor type protein tyrosine phosphatase-kappa promotes squamous cell carcinoma. Journal of Investigative Dermatology, 135, S24.
4. Xu, Y., Xue, S., & Zhou, J., et al. (2015). Notch and TGF-β pathways cooperatively regulate receptor protein tyrosine phosphatase-κ (PTPRK) gene expression in human primary keratinocytes. Molecular Biology of the Cell, 26(6), 1199–1206.
5. Yang, H., Xu, Y., & Xia, W., et al. (2014). Suppression of epidermal growth factor receptor activation by receptor protein tyrosine phosphatase-kappa reduces ultraviolet irradiation-induced epidermal hyperplasia and. Journal of Investigative Dermatology, 134, S115.
6. Quan, T., Xu, Y., & Qin, Z., et al. (2014). Elevated YAP and its downstream targets CCN1 and CCN2 in basal cell carcinoma: Impact on keratinocyte proliferation and stromal cell activation. The American Journal of Pathology, 184(4), 937–943.
7. Xu, Y., & Fisher, G. J. (2013). Role of met axis in head and neck cancer. Cancers, 5(4), 1601–1618.
8. Xu, Y., Xue, S., & Zhou, J., et al. (2013). Notch signaling attenuates epidermal growth factor receptor activation by induction of receptor protein tyrosine phosphatase-kappa in primary human keratinocytes. Journal of Investigative Dermatology, 133, S152.
9. Xu, Y., Zhou, J., & Carey, T. E., et al. (2012). Receptor-type protein tyrosine phosphatase β regulates Met phosphorylation and function in head and neck squamous cell carcinoma. Neoplasia, 14(11), 1015–1022.
10. Xu, Y., & Fisher, G. J. (2012). Receptor type protein tyrosine phosphatases (RPTPs)–roles in signal transduction and human disease. Journal of Cell Communication and Signaling, 6(3), 125–138.
11. Riser, B. L., Bhagavathula, N., & Perone, P., et al. (2012). Gadolinium-induced fibrosis is counter-regulated by CCN3 in human dermal fibroblasts: A model for potential treatment of nephrogenic systemic fibrosis. Journal of Cell Communication and Signaling, 6(2), 97–105.
12. Xu, Y., Zhou, J., & Carey, T. E., et al. (2012). Receptor-type protein tyrosine phosphatase-beta (RPTP-beta) regulation of Met function in squamous cell carcinoma. Journal of Investigative Dermatology, 132, S25.
13. Quan, T., Qin, Z., & Shao, Y., et al. (2011). Retinoids suppress cysteine‐rich protein 61 (CCN1), a negative regulator of collagen homeostasis, in skin equivalent cultures and aged human skin in vivo. Experimental Dermatology, 20(7), 572–576.
14. Xu, Y., Xia, W., & Baker, D., et al. (2011). Receptor-type protein tyrosine phosphatase β (RPTP-β) directly dephosphorylates and regulates hepatocyte growth factor receptor (HGFR/Met) function. Journal of Biological Chemistry, 286(18), 15980–15988.
15. Xu, Y., Vicentini, F. T., & He, T., et al. (2011). Quercetin inhibits UV irradiation induced inflammatory cytokine production in primary human keratinocytes by suppressing NF-kappa B pathway. Journal of Investigative Dermatology, 131, S111.
16. Vicentini, F. T., He, T., & Shao, Y., et al. (2011). Quercetin inhibits UV irradiation-induced inflammatory cytokine production in primary human keratinocytes by suppressing NF-κB pathway. Journal of Dermatological Science, 61(3), 162–168.
17. Li, Y., Liu, Y., & Xu, Y., et al. (2010). UV irradiation induces Snail expression by AP-1 dependent mechanism in human skin keratinocytes. Journal of Dermatological Science, 60(2), 105–113.
18. Quan, T., Qin, Z., & Xu, Y., et al. (2010). Ultraviolet irradiation induces CYR61/CCN1, a mediator of collagen homeostasis, through activation of transcription factor AP-1 in human skin fibroblasts. Journal of Investigative Dermatology, 130(6), 1697–1706.

Profile Details

https://www.researchgate.net/profile/Yiru-Xu
https://scholar.google.com/citations?user=Keuur_EAAAAJ&hl=en

WOS ResearchID: EEM-6873-2022