Biography

Prof. Suresh C. Tyagi

University of Louisville, USA


Email: [email protected]


Qualifications

1980 Ph.D., University of Aligarh, India

1977 M.Phil., University of Aligarh, India


Publications (selected)

  1. George, A. K., Behera, J., Homme, R. P., Tyagi, N., Tyagi, S. C., & Singh, M. (2021). Rebuilding microbiome for mitigating traumatic brain injury: importance of restructuring the gut-microbiome-brain axis. Molecular Neurobiology, 58(8), 3614-3627.
  2. Hayden, M. R., & Tyagi, S. C. (2021). Impaired folate-mediated one-carbon metabolism in type 2 diabetes, late-onset Alzheimer’s disease and long COVID. Medicina, 58(1), 16.
  3. Behera, J., Ison, J., Tyagi, S. C., & Tyagi, N. (2020). The role of gut microbiota in bone homeostasis. Bone, 135, 115317.
  4. Familtseva, A., Jeremic, N., & Tyagi, S. C. (2019). Exosomes: cell-created drug delivery systems. Molecular and cellular biochemistry, 459, 1-6.
  5. Behera, J., George, A. K., Voor, M. J., Tyagi, S. C., & Tyagi, N. (2018). Hydrogen sulfide epigenetically mitigates bone loss through OPG/RANKL regulation during hyperhomocysteinemia in mice. Bone, 114, 90-108.
  6. Homme, R. P., Singh, M., Majumder, A., George, A. K., Nair, K., Sandhu, H. S., ... & Tyagi, S. C. (2018). Remodeling of retinal architecture in diabetic retinopathy: disruption of ocular physiology and visual functions by inflammatory gene products and pyroptosis. Frontiers in Physiology, 9, 1268.
  7. Majumder, A., Singh, M., Behera, J., Theilen, N. T., George, A. K., Tyagi, N., ... & Tyagi, S. C. (2018). Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury. American Journal of Physiology-Cell Physiology, 315(5), C609-C622.
  8. Singh, M., & Tyagi, S. C. (2018). Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders. International journal of ophthalmology, 11(1), 117.
  9. Jeremic, N., Chaturvedi, P., & Tyagi, S. C. (2017). Browning of white fat: novel insight into factors, mechanisms, and therapeutics. Journal of cellular physiology, 232(1), 61-68.
  10. Theilen, N. T., Kunkel, G. H., & Tyagi, S. C. (2017). The role of exercise and TFAM in preventing skeletal muscle atrophy. Journal of cellular physiology, 232(9), 2348-2358.
  11. Behera, J., Bala, J., Nuru, M., Tyagi, S. C., & Tyagi, N. (2017). Homocysteine as a pathological biomarker for bone disease. Journal of cellular physiology, 232(10), 2704-2709.
  12. Pushpakumar, S., Ren, L., Kundu, S., Gamon, A., Tyagi, S. C., & Sen, U. (2017). Toll-like receptor 4 deficiency reduces oxidative stress and macrophage mediated inflammation in hypertensive kidney. Scientific reports, 7(1), 6349.
  13. Singh, M., & Tyagi, S. C. (2017). Metalloproteinases as mediators of inflammation and the eyes: molecular genetic underpinnings governing ocular pathophysiology. International Journal of Ophthalmology, 10(8), 1308.
  14. Sood HS, Hunt MJ, Tyagi SC. Peroxisome proliferator ameliorates endothelial dysfunction in a murine model of hyperhomocysteinemia, Am J Physiol, 2003; 284: L333-L341.
  15. Camp T, Smiley L, Hayden MR, Tyagi SC. Mechanism of Matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats, J Hyperten, 2003; 21(9): 1719-1727. An editorial on this paper, page: 1627-1630.
  16. Camp TM, Tyagi SC, Senior RM, Hayden MR, Tyagi SC. Gelatinase B (MMP-9) an apoptotic factor in diabetic transgenic mice, Diabetologia. 2003, 46(10): 1438-1445.
  17. Reddy KH, Tjahja IE, Campbell SE, Janicki JS, Hayden MR, Tyagi SC. Expression of MMP activity in idiopathic dilated cardiomyopathy: A marker of cardiac dilatation. Mol Cell Biochem, 2004; 264: 183-191.
  18. Smiley LM, Camp TM, Lucchesi PA, Tyagi SC. Peroxisome proliferator ameliorates endocardial endothelial and muscarinic dysfunction in spontaneously hypertensive rats, Antioxidants & Redox Signaling, 2004, 6(2): 367-374.
  19. Camp TM, Tyagi SC, Aru GM, Hayden MR, Mehta JL, Tyagi SC. Doxycycline ameliorates ischemic and border zone remodeling and endothelial dysfunction after MI in rats, J Heart Lung Transplant, 2004, 23: 729-736.
  20. Cox MJ, Hawkins UA, Hoit BD, Tyagi SC. Attenuation of oxidative stress and remodeling by cardiac inhibitor of metalloproteinase protein transfer, Circulation, 109(17): 2123-2128, 2004.
  21. Shastry S, Tyagi SC. Homocysteine induces metalloproteinase and shedding of ß-1 integrin in microvessel endothelial cells, J Cell Biochem, 2004, 93: 207-213.
  22. Shastry S, Tyagi N, Tyagi SC. Proteomic analysis of Hcy-inhibition of microvascular endothelial cell angiogenesis, Cell Mol Biol; 2004 Dec; 50(8): 931-7.
  23. Carroll JF, Tyagi SC. ECM remodeling in heart of Hcy-mic obese rabbit, Am J Hypertens, 18(5): 692-698, 2005.
  24. Moshal KS, Tyagi N, Henderson B, Ovechkin AV, Tyagi SC. Protease activated receptor and endothelial-myocyte uncoupling in chronic heart failure, Am J Physiol (Heart & Circulatory), 2005 Jun; 288(6): H2770-7.
  25. Tyagi N, Moshal KS, Lominadze D, Ovechkin AV, Tyagi SC. Hcy-dependent cardiac remodeling & endothelial-myocyte coupling in 2K1C Goldblatt hypertension mouse model. Canad J Physiol & Pharmac, 83(7): 583-594, 2005.
  26. Moshal KS, Tyagi N, Moss V, Henderson B, Steed M, Ovechkin A, Aru GM, Tyagi SC. Early induction of matrix metalloproteinase-9 transduces signaling in human heart end stage failure, J Cell Mol Med, 8(3): 704-713, 2005.
  27. Shastry S, Moning L, Tyagi N, Steed M, Tyagi SC. GABA receptors and nitric oxide ameliorate constrictive collagen remodeling in hyperhomocysteinemia, J Cell Physiol, 205(3): 422-7, 2005.
  28. Tyagi N, Moshal KS, Ovechkin AV, Rodriguez W, Steed M, Henderson B, Roberts AM, Joshua IG, Tyagi SC. Mitochondrial mechanism of oxidative stress and systemic hypertension in HHcy, J Cell Biochem, 96: 665-671, 2005.
  29. Passmore JC, Joshua IG, Rowell P, Tyagi SC, Falcone JC. Reduced Alpha Adrenergic Mediated Contraction of Renal Preglomerular Blood Vessels as a Function of Gender and Aging, J Cell Biochem, 96(4): 672-681, 2005.
  30. Tyagi N, Sordis KC, Moshal KS, Ovechkin AV, Tyagi SC. Mechanisms of Homocysteine-Induced Oxidative stress, Am J Physiol Heart & Circulatory Physiol, 289(6): H2649-56, 2005.
  31. Ovechkin AV, Tyagi N, Rodriguez WE, Hayden MR, Moshal KS, Tyagi SC. Role of MMP-9 in endothelial apoptosis in chronic heart failure in mice. J Appl Physiol, 99(6): 2398-405, 2005.
  32. Moshal KS, Sen U, Tyagi N, Henderson B, Steed M, Ovechkin AV, Tyagi SC. Regulation of Hcy-induced MMP-9 by extracellular regulated protein kinase-1/2 (ERK-1/2) pathway, Am J Physiol Cell Physiol, 290(3): C883-91, 2006.
  33. Lominadze D, Roberts AM, Tyagi N, Moshal KS, Tyagi SC. Homocysteine causes cerebrovascular leakage in mice. Am J Physiol Heart & Circulatory Physiol, H1206-13, 2006.


Profile Details

https://louisville.edu/bucksforbrains/faculty/tyagi
https://loop.frontiersin.org/people/52487
https://www.researchgate.net/scientific-contributions/Suresh-C-Tyagi-39210475

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