Dr. Zvi Kelman

University of Maryland, USA

Email: [email protected]

Qualifications

1996  Ph.D., Sloan-Kettering Cancer Center, USA

1989  M.Sc., The Weizmann Institute of Science, Israel

1987  B.Sc., The Hebrew University of Jerusalem, Israel

Publications (selected)

1. Bolla, V., O'Dell, W. B., Harsha, S., et al. (2027). A benchmark fed-batch bioprocess for production of cNISTmAb using NISTCHO. Protein Expression and Purification, 244, 107020.
2. Cleveland, M. H., Karageorgos, I. L., Marino, J. P., et al. (2025). Recommended nomenclature convention for the NISTCHO cell line and its product monoclonal antibody, cNISTmAb. mAbs, 17(1), 2490789.
3. Dahodwala, H., Hodzic, I., Slesarev, A., et al. (2025). Development and Characterization of the NISTCHO Reference Cell Line. Biotechnology Journal, 20(5), e70012.
4. Szalai, V. A., Bergonzo, C., Lyon, R. B., et al. (2025). Structure and Dynamics of Monoclonal Antibody Domains Using Spins, Scattering, and Simulations. ChemMedChem, 20(8), e202400917.
5. Ikonomova, S. P., Yan, B., Sun, Z. Y., et al. (2025). Engineering GID4 for use as an N-terminal proline binder via directed evolution. Biotechnology and Bioengineering, 122(1), 179–188.
6. Cowan, D. A., Albers, S. V., Antranikian, G., et al. (2024). Extremophiles in a changing world. Extremophiles, 28(2), 26.
7. Siegall, W. B., Lyon, R. B., & Kelman, Z. (2024). An important consideration when expressing mAbs in Escherichia coli. Protein Expression and Purification, 220, 106499.
8. Bergonzo, C., Hoopes, J. T., Kelman, Z., et al. (2024). Effects of glycans and hinge on dynamics in the IgG1 Fc. Journal of Biomolecular Structure & Dynamics, 42(22), 12571–12579.
9. Callahan, N., Siegall, W. B., Bergonzo, C., et al. (2023). Contributions from ClpS surface residues in modulating N-terminal peptide binding and their implications for NAAB development. Protein Engineering Design & Selection, 36, gzad007.
10. Alfaro, J. A., Bohländer, P., Dai, M., et al. (2021). The emerging landscape of single-molecule protein sequencing technologies. Nature Methods, 18(6), 604–617.
11. Sinha, N. J., Kloxin, C. J., Saven, J. G., et al. (2021). Recombinant expression of computationally designed peptide-bundlemers in Escherichia coli. Journal of Biotechnology, 330, 57–60.
12. Telu, K. H., Marupaka, R., Andriamaharavo, N. R., et al. (2021). Creation and filtering of a recurrent spectral library of CHO cell metabolites and media components. Biotechnology and Bioengineering, 118(4), 1491–1510.
13. Tullman, J., Marino, J. P., & Kelman, Z. (2020). Leveraging nature's biomolecular designs in next-generation protein sequencing reagent development. Applied Microbiology and Biotechnology, 104(17), 7261–7271.
14. Kelman, L. M., O'Dell, W. B., & Kelman, Z. (2020). Unwinding 20 Years of the Archaeal Minichromosome Maintenance Helicase. Journal of Bacteriology, 202(6), e00729-19.
15. Tullman, J., Christensen, M., Kelman, Z., et al. (2020). A ClpS-based N-terminal amino acid binding reagent with improved thermostability and selectivity. Biochemical Engineering Journal, 154, 107438.
16. Callahan, N., Tullman, J., Kelman, Z., et al. (2020). Strategies for Development of a Next-Generation Protein Sequencing Platform. Trends in Biochemical Sciences, 45(1), 76–89.
17. Leith, E. M., O'Dell, W. B., Ke, N., et al. (2019). Characterization of the internal translation initiation region in monoclonal antibodies expressed in Escherichia coli. Journal of Biological Chemistry, 294(48), 18046–18056.
18. Gardner, A. F., & Kelman, Z. (2019). Editorial: The DNA Replication Machinery as Therapeutic Targets. Frontiers in Molecular Biosciences, 6, 35.
19. Tullman, J., Callahan, N., Ellington, B., et al. (2019). Engineering ClpS for selective and enhanced N-terminal amino acid binding. Applied Microbiology and Biotechnology, 103(6), 2621–2633.
20. Ashkar, R., Bilheux, H. Z., Bordallo, H., et al. (2018). Neutron scattering in the biological sciences: progress and prospects. Acta Crystallographica Section D: Structural Biology, 74(12), 1129–1168.
21. Altieri, A. S., & Kelman, Z. (2018). DNA Sliding Clamps as Therapeutic Targets. Frontiers in Molecular Biosciences, 5, 87.
22. Zatopek, K. M., Gardner, A. F., & Kelman, Z. (2018). Archaeal DNA replication and repair: new genetic, biophysical and molecular tools for discovering and characterizing enzymes, pathways and mechanisms. FEMS Microbiology Reviews, 42(4), 477–488.
23. Kelman, L. M., & Kelman, Z. (2018). Do Archaea Need an Origin of Replication? Trends in Microbiology, 26(3), 172–174.
24. Kashi, L., Yandrofski, K., Preston, R. J., et al. (2018). Heterologous recombinant expression of non-originator NISTmAb. mAbs, 10(6), 922–933.
25. Reddy, P. T., Brinson, R. G., Hoopes, J. T., et al. (2018). Platform development for expression and purification of stable isotope labeled monoclonal antibodies in Escherichia coli. mAbs, 10(7), 992–1002.

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