Prof. Tarek Aboul-Fadl

Department of Medicinal Chemistry, Faculty of Pharmacy

Assiut University, Egypt

Professor

Email: [email protected], [email protected]

Qualifications

1994 Ph.D., Pharmaceutical Medicinal Chemistry, Assiut University-Josai University, Egypt

1989 M.S., Pharmaceutical chemistry, Assiut University, Egypt

1984 B.S., Pharmaceutical Sciences, Assiut University, Egypt

Publications (Selected)

1. Sweify, I. R., El-Wahab, H. A. A. A., Qayed, W. S., et al. (2026). Crystal structure and computational study of a multifunctional 3-Spi-ro-2-oxindole derivative: Ethyl 4-[2-(2′-oxospiro[1,3-dioxolane-2,3′-indol]-1′(2′H)-yl)acetamido]benzoate. Journal of Molecular Structure, 1373, Article 146702.
2. Sweify, I. R., Abd El-Wahab, H. A. A., Qayed, W. S., et al. (2026). Ligand-based design and synthesis of novel 3-spiro-2-oxindoline derivatives as potent VEGFR-2 inhibitors with antiproliferative activity and cell cycle arrest. Bioorganic Chemistry, 181, Article 110313.
3. Qayed, W. S., Hassan, M. A., Senol, H., et al. (2026). 2-Oxoindolin-thiazoline hybrids as scaffold-based therapeutics for T2DM-associated cognitive impairment: design, synthesis, in vitro and in silico studies. RSC Medicinal Chemistry, 17(1), 317–342.
4. Sharkawy, M. A., Aboraia, A. S., Bandaru, S. S. M., et al. (2026). Crystal Structure and Quantum Chemical Calculations of 2-(2′-Oxospiro[1,3-dioxolane-2,3′-indol]-1′(2′H)-yl) acetohydrazide. Journal of Heterocyclic Chemistry, 63(1), 94–105.
5. Shin, S.-H., Ye, M.-K., Chae, M.-H., et al. (2025). Lidocaine-Based Derivatives for the Treatment of Staphylococcal Enterotoxin B-Induced Chronic Rhinosinusitis. International Journal of Molecular Sciences, 26(17), Article 8137.
6. Abdel-Hafez, G. A., Klopotowska, D., Filip-Psurska, B., et al. (2025). Hybrid nucleobase-heterocycle-2-oxindole scaffolds as innovative cell cycle modulators with potential anticancer activity. RSC Advances, 15(36), 29753–29776.
7. Shin, S.-H., Ye, M.-K., Chae, M.-H., et al. (2024). Anti-Allergic and Anti-Inflammatory Effects of Lidocaine-Derived Organic Compounds in a House Dust Mite-Induced Allergic Rhinitis Mouse Model. Biomedicines, 12(9), Article 1965.
8. Shin, S.-H., Ye, M.-K., Chae, M.-H., et al. (2023). Effects of Lidocaine-Derived Organic Compounds on Eosinophil Activation and Survival. Molecules, 28(15), Article 5696.
9. Qayed, W. S., Hassan, M. A., Abouwarda, A. M., et al. (2024). Computational Design of Azine-Linked Hybrids of 2-Indolinone-Thiazolodine Scaffold as Novel and Promising Quorum Sensing Inhibitors. Polycyclic Aromatic Compounds, 44(1), 1–24.
10. Qayed, W. S., Hassan, M. A., El-Sayed, W. M., et al. (2022). Novel Azine Linked Hybrids of 2-Indolinone and Thiazolodinone Scaffolds as CDK2 Inhibitors with Potential Anticancer Activity: In Silico Design, Synthesis, Biological, Molecular Dynamics and Binding Free Energy Studies. Bioorganic Chemistry, 126, Article 105884.
11. Abd El-wahab, H. A. A., Mansour, H. S., Ali, A. M., et al. (2022). New cell cycle checkpoint pathways regulators with 2-Oxo-indoline scaffold as potential anticancer agents: Design, synthesis, biological activities and in silico studies. Bioorganic Chemistry, 120, Article 105622.
12. Yousef, M. A., Ali, A. M., El-Sayed, W. M., et al. (2022). Design and synthesis of novel isatin-based derivatives targeting cell cycle checkpoint pathways as potential anticancer agents (vol 105, 104366, 2020). Bioorganic Chemistry, 120, Article 105598.
13. El-wahab, H. A. A. A., Hamdy, A. K., Schulzke, C., et al. (2021). Crystal structure and quantum chemical calculations of (E)1-benzyl-3-((4-methoxyphenyl)imino)-5-methylindolin-2-one. Journal of Heterocyclic Chemistry, 58(8), 1601–1609.
14. Mansour, H. S., Abd El-wahab, H. A. A., Ali, A. M., & Aboul-Fadl, T. (2021). Inversion kinetics of some E/Z 3-(benzylidene)-2-oxo-indoline derivatives and their in silico CDK2 docking studies. RSC Advances, 11(14), 7839–7850.
15. Yousef, M. A., Ali, A. M., El-Sayed, W. M., et al. (2020). Design and synthesis of novel isatin-based derivatives targeting cell cycle checkpoint pathways as potential anticancer agents. Bioorganic Chemistry, 105, Article 104366.
16. Aboul-Fadl, T., Al-Hamad, S. S., & Fouad, E. A. (2018). Pharmacokinetic studies of naproxen amides of some amino acid esters with promising colorectal cancer chemopreventive activity. Bioorganic Chemistry, 76, 370–379.
17. Abdu-Allah, H. H. M., Youssif, B. G. M., Abdelrahman, M. H., et al. (2017). Synthesis and anti-mycobacterial activity of 4-(4-phenyl-1H-1,2,3-triazol-1-yl)salicylhydrazones: revitalizing an old drug. Archives of Pharmacal Research, 40(2), 168–179.
18. Elsaman, T., Aldeeb, O. A. A., Aboul-Fadl, T., & Hamedelneil, E. I. (2017). Synthesis, characterization and pharmacological evaluation of certain enzymatically cleavable NSAIDs amide prodrugs. Bioorganic Chemistry, 70, 144–152.
19. Osman, A. M. G., Abourashed, E. A., Slade, D., et al. (2015). Synthesis and in vitro evaluation of ferutinol aryl esters for estrogenic activity and affinity toward cannabinoid receptors. Medicinal Chemistry Research, 24(6), 2670–2678.
20. Aboul-Fadl, T., Al-Hamad, S. S., Lee, K., et al. (2014). Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention. Medicinal Chemistry Research, 23(9), 4177–4188.
21. Aboul-Fadl, T., Elsaman, T., Al-Deeb, O. A., et al. (2014). Some New NSAIDs Prodrugs: An Efficient Synthesis, Spectral Characterization and X-ray Crystal Structure Studies. Asian Journal of Chemistry, 26(16), 5249–5254.
22. Aboul-Fadl, T., Abdel-Hamid, M. K., & Youssef, A. F. (2013). Efficient Schiff bases of indoline-2,3-dione (isatin) derivatives against single resistant strains of Mycobacterium tuberculosis. Abstracts of Papers of the American Chemical Society, 246.

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