Dept. of Neurosurgery
SUNY Upstate Medical University, USA
Associate Professor, Director for Stroke Research and Brain Repair

Email: [email protected]

Qualifications

2004 Ph.D., Neuroscience/Neurobiology, Lund University, Sweden

1982 M.D., Medicine, Hebei Medical University, China

Publications (Selected)

1. Var, S. R., Strell, P., Shetty, A., et al. (2025). Research guideline recommendations for research on stem cells, human embryos, and gene editing. Cell Transplantation, 34, Article 09636897241312793.
2. Ren, X. S., He, J., Li, S., et al. (2024). Hematopoietic growth factors regulate the entry of monocytes into the adult brain via chemokine receptor CCR5. International Journal of Molecular Sciences, 25(16), Article 8898.
3. Gardner, R. S., Kyle, M., Hughes, K., & Zhao, L.-R. (2024). Single-cell RNA sequencing reveals immunomodulatory effects of stem cell factor and granulocyte colony-stimulating factor treatment in the brains of aged APP/PS1 mice. Biomolecules, 14(7), Article 827.
4. Addo, A., & Zhao, L.-R. (2024). Transcriptional analysis reveals new mechanisms of SCF plus G-CSF-reduced neuropathology in APP/PS1 mice. Cell Transplantation, 33.
5. Lovier, M. A., Kyle, M., Gardner, R., et al. (2024). The effects of a supportive enriched environment on neurological function recovery of chronic severe TBI in a murine model. Cell Transplantation, 33.
6. Qiu, X., Ping, S., Kyle, M., et al. (2023). Stem cell factor and granulocyte colony-stimulating factor promote remyelination in the chronic phase of severe traumatic brain injury. Cells, 12(5), Article 705.
7. Qiu, X., Ping, S., Kyle, M., et al. (2023). SCF plus G-CSF treatment enhances remyelination in the chronic phase of severe traumatic brain injury. Cell Transplantation, 32, 20–21.
8. Gardner, R. S., Kyle, M., Hughes, K., & Zhao, L. R. (2022). Single-cell RNA sequencing reveals immunomodulatory effects of stem cell factor and granulocyte colony-stimulating factor in aged APP/PS1 mice. Cell Transplantation, 31.
9. Ping, S., Hughes, K., Kyle, M., & Zhao, L.-R. (2021). Hematopoietic growth factors attenuate CADASIL-caused cerebrovascular degeneration through enhancing mural cell survival. Cell Transplantation, 30, 18–18.
10. Qiu, X., Ping, S., Kyle, M., et al. (2021). SCF plus G-CSF treatment in the chronic phase of severe TBI enhances axonal sprouting in the spinal cord and synaptic pruning in the hippocampus. Acta Neuropathologica Communications, 9(1), Article 63.
11. Ping, S., Qiu, X., & Zhao, L.-R. (2021). Brain-derived CCR5 contributes to neuroprotection and brain repair after experimental stroke. Aging and Disease, 12(1), 72–92.
12. Ping, S., Qiu, X., Gonzalez-Toledo, M. E., et al. (2021). Stem cell factor in combination with granulocyte colony-stimulating factor protects the brain from capillary thrombosis-induced ischemic neuron loss in a mouse model of CADASIL. Frontiers in Cell and Developmental Biology, 8, Article 627733.
13. Guo, X., Liu, Y., Morgan, D., & Zhao, L.-R. (2020). Reparative effects of stem cell factor and granulocyte colony-stimulating factor in aged APP/PS1 mice. Aging and Disease, 11(6), 1423–1443.
14. He, J., Russell, T., Qiu, X., et al. (2020). The contribution of stem cell factor and granulocyte colony-stimulating factor in reducing neurodegeneration and promoting neurostructure network reorganization after traumatic brain injury. Brain Research, 1746, Article 147000.
15. Qiu, X., Ping, S., Kyle, M., et al. (2020). Long-term beneficial effects of hematopoietic growth factors on brain repair in the chronic phase of severe traumatic brain injury. Experimental Neurology, 330, Article 113335.
16. Qiu, X., Ping, S., Kyle, M., et al. (2020). S100 calcium-binding protein A9 knockout contributes to neuroprotection and functional improvement after traumatic brain injury. Journal of Neurotrauma, 37(7), 950–965.
17. Ping, S., Qiu, X., Kyle, M., et al. (2019). Stem cell factor and granulocyte colony-stimulating factor promote brain repair and improve cognitive function through VEGF-A in a mouse model of CADASIL. Neurobiology of Disease, 132, Article 104561.
18. Guo, X., Liu, Y., Longo, S., & Zhao, L.-R. (2019). Reparative effects of stem cell factor and granulocyte colony-stimulating factor in aged APP/PS1 mice. Cell Transplantation, 28(4), 470–471.
19. He, J., Russell, T., Longo, S., & Zhao, L.-R. (2019). The contribution of stem cell factor and granulocyte colony-stimulating factor in reducing neurodegeneration and promoting neural network reorganization after traumatic brain injury. Cell Transplantation, 28(4), 471–471.
20. Zhao, L.-R. (2019). Brain repair by hematopoietic growth factors in the subacute phase of traumatic brain injury (vol 129, pg 1286, 2018). Journal of Neurosurgery, 130(4), 1398–1398.

Profile Details
https://researchconnect.upstate.edu/en/persons/li-ru-zhao/
https://www.researchgate.net/scientific-contributions/Li-Ru-Zhao-39930488
https://www.linkedin.com/in/li-ru-zhao-923030187

WOS ResearcherID: GKC-6867-2022