Biography

Dr. Sheng-He Huang

Keck School of Medicine

University of Southern California (USC), Los Angeles, USA

Associate Professor


Email: [email protected]


Qualifications

1986–1989 Postdoctoralfellow, Children’s Hospital Los Angeles, USC, USA

1978–1981 M.D., Institute of Basic Med. Sci., Chinese Academy of Medical Sciences (CAMS)/Peking Union Medical College (PUMC), Beijing, China

1970-1973 B.S,The First Medical University of the PLA (Southern Medical University), Guangzhou, China


Publications (selected)
  1. Zhou, B., Meng, X., Yu, Z., et al. (2026). Vimentin-NF-κB signaling contributing to IbeA-mediated adhesion, invasion, and biofilm formation during Escherichia coli K1 traversal of the blood-brain barrier. Frontiers in Immunology, 17, Article 1793594.
  2. He, X., Yang, W., Zeng, Z., et al. (2026). NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology (vol 17, pg 283, 2020). Cellular & Molecular Immunology, 23(4), 432-436.
  3. Yu, J., Li, X., Zhou, D., et al. (2022). Vimentin Inhibits Dengue Virus Type 2 Invasion of the Blood-Brain Barrier. Frontiers in Cellular and Infection Microbiology, 12, Article 868407.
  4. He, X., Wang, L., Liu, L., et al. (2021). Endogenous α7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier. Frontiers in Immunology, 12, Article 745854.
  5. Xiao, Y., Zhang, T., Li, Y., et al. (2022). Memantine Promotes Bactericidal Effect of Neutrophils Against Infection with Pseudomonas aeruginosa and Its Drug-Resistant Strain, by Improving Reactive Oxygen Species Generation. Microbial Drug Resistance, 28(1), 7-17.
  6. Wu, C., Yang, M., Liu, R., et al. (2020). Nicotine Reduces Human Brain Microvascular Endothelial Cell Response toEscherichia coliK1 Infection by Inhibiting Autophagy. Frontiers in Cellular and Infection Microbiology, 10, Article 484.
  7. He, X., Yang, W., Zeng, Z., et al. (2020). NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology. Cellular & Molecular Immunology, 17(3), 283-299.
  8. Peng, L., Li, L., He, X., et al. (2020). Memantine Displays Antimicrobial Activity by Enhancing Escherichia coli Pathogen-Induced Formation of Neutrophil Extracellular Traps. Frontiers in Cellular and Infection Microbiology, 10, Article 47.
  9. Gao, J., Li, Y., Wan, Y., et al. (2019). A Novel Postbiotic From Lactobacillus rhamnosus GG With a Beneficial Effect on Intestinal Barrier Function. Frontiers in Microbiology, 10, Article 477.
  10. Liu, R., Wu, C., Li, L., et al. (2019). CD48 and 7 Nicotinic Acetylcholine Receptor Synergistically Regulate FimH-Mediated Escherichia coli K1 Penetration and Neutrophil Transmigration Across Human Brain Microvascular Endothelial Cells. Journal of Infectious Diseases, 219(3), 470-479.
  11. Zeng, Q., He, X., Puthiyakunnon, S., et al. (2017). Probiotic Mixture Golden Bifido Prevents Neonatal Escherichia coli K1 Translocation via Enhancing Intestinal Defense. Frontiers in Microbiology, 8, Article 1798.
  12. He, X., Zeng, Q., Puthiyakunnon, S., et al. (2017). Lactobacillus rhamnosus GG supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense. Scientific Reports, 7, Article 43305.
  13. Liu, L., Yu, J., Li, L., et al. (2017). Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine. Scientific Reports, 7, Article 40467.
  14. Puthiyakunnon, S., He, X., Boddu, S., et al. (2017). C-Met Inhibitors are Potential Novel Therapeutic Agents Against Listeria monocytogenes Infection Through Blocking the Bacteria Entry into Non-phagocytic Cells. Current Topics in Medicinal Chemistry, 17(3), 278-289.
  15. Huang, S., Chi, F., Peng, L., et al. (2016). Vimentin, a Novel NF-κB Regulator, Is Required for Meningitic Escherichia coli K1-Induced Pathogen Invasion and PMN Transmigration across the Blood-Brain Barrier. PLOS ONE, 11(9), Article e0162641.
  16. Yang, Z., Jiang, Y., Ma, C., et al. (2016). Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque. PLOS ONE, 11(6), Article e0156170.
  17. Peng, L., Jiang, Q., Pan, J., et al. (2016). Involvement of polyphosphate kinase in virulence and stress tolerance of uropathogenic Proteus mirabilis. Medical Microbiology and Immunology, 205(2), 97-109.
  18. Shi, X., Lin, Y., Qiu, Y., et al. (2016). Comparative Screening of Digestion Tract Toxic Genes in Proteus mirabilis. PLOS ONE, 11(3), Article e0151873.
  19. He, X., Shi, X., Puthiyakunnon, S., et al. (2016). CD44-mediated monocyte transmigration across Cryptococcus neoformans-infected brain microvascular endothelial cells is enhanced by HIV-1 gp41-I90 ectodomain. Journal of Biomedical Science, 23, Article 28.
  20. Wang, S., Peng, L., Gai, Z., et al. (2016). Pathogenic Triad in Bacterial Meningitis: Pathogen Invasion, NF-κB Activation, and Leukocyte Transmigration that Occur at the Blood-Brain Barrier. Frontiers in Microbiology, 7, Article 148.


Profile Details

https://www.researchgate.net/profile/Sheng-He-Huang
https://loop.frontiersin.org/people/293104/overview

WOS ResearcherID: HYO-3379-2023

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