Dr. Ian S. Haworth

Email: [email protected]

Qualifications

1986-1989 Ph.D., Physical Organic Chemistry, University of Liverpool, UK

Publications(Selected)

1. M. J. Law, D. S. Lee, C. S. Lee, P. P. Anglim, I. S. Haworth, I. A. Laird-Offringa. The role of the C-terminal helix of U1A protein in the interaction with U1hpII RNA Nucleic Acids Res. 2013, 41, 7092-100.
2. R. M. Romero, P. Rojsitthisak, I. S. Haworth. Electrophoretic mobility of duplex DNA crosslinked by mechlorethamine at a cytosine-cytosine mismatch pair. Electrophoresis, 2013, 34, 917-24.
3. Y. Li, M. M. Hatmal, R. Langen, I. S. Haworth. Idealized models of protofilaments of human islet amyloid polypeptide. J. Chem. Inf. Model., 2012, 52, 2983-91.
4. A. Popova, M. M. Hatmal, M. Frushicheva, E. A. Price, P. Z. Qin, I. S. Haworth. Nitroxide sensing of a DNA microenvironment: mechanistic insights from EPR spectroscopy and molecular dynamics simulations. J. Phys. Chem. B, 2012, 116, 6387-96.
5. X. Zhang, C-S. Tsung, G. Z. Zowa, M. M. Hatmal, I. S. Haworth, P. Z. Qin. Global structure of a three-way junction in a phi29 packaging RNA dimer determined using site-directed spin labeling. J. Am. Chem. Soc., 2012, 134, 2644-52.
6. S. Bedrood, Y. Li, J. M. Isas, B. G. Hegde, U. Baxa, I. S. Haworth, R. Langen. Fibril structure of human islet amyloid polypeptide. J. Biol. Chem., 2012, 287, 5235-41.
7. M. M. Hatmal, Y. Li, B.G. Hegde, P.B. Hegde, C.C. Jao, R. Langen, I.S. Haworth. Computer modeling of nitroxide spin labels on proteins. Biopolymers, 2012, 97, 35-44.
8. Y. Li, B.T. Sutch, H-H. Bui, T.K. Gallaher, I.S.Haworth. Modeling of the water network at protein-RNA interfaces. J. Chem. Inf. Model., 2011, 51, 1347-52.
9. P. Rojsitthisak, N. Jongaroonngamsang, R.M. Romero, I.S. Haworth. HPLC-UV, MALDI-TOF-MS and ESI-MS/MS analysis of the mechlorethamine DNA crosslink at a cytosine-cytosine mismatch pair. PLoS ONE, 2011, 2011, 6, e20745.
10. L. Xu, Y.Li, I.S.Haworth, D.L.Davies. Functional role of the intracellular loop linking transmembrane domains 6 and 7 of the human dipeptide transporter hPEPT1. J. Membr. Biol., 2010, 238, 43-9.
11. C. C.Jao, B.G.Hegde, J.L.Gallop, P.B.Hegde, H.T.McMahon, I.S.Haworth, R.Langen. Roles of amphipathic helices and the BAR domain of endophilin in membrane curvature generation. J. Biol. Chem., 2010, 285, 20164-70.
12. B.T. Sutch, E.J. Chambers, M.Z. Bayramyan, T.K. Gallaher,I.S. Haworth.Similarity of protein-RNA interfaces based on motif analysis. J. Chem. Inf. Model., 2009, 49, 2139-46.
13. L.Xu, I.S.Haworth, A.A.Kulkarni, M.B.Bolger, D.L.Davies. Mutagenesis and cysteine scanning of transmembrane 10 of the human dipeptide transporter. Pharm. Res., 2009, 26, 2358-66.
14. A.G.Tsai, A.E.Engelhart, M.M.Hatmal, S.I.Houston, N.V.Hud, I.S.Haworth and M.R.Lieber. Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites. J. Biol. Chem., 2009, 284, 7157-7164.
15. C.C.Jao, B.G.Hegde, J.Chen, I.S.Haworth, R.Langen. Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement. Proc. Natl. Acad. Sci. USA., 2008, 105, 19666-71.
16. Y.Zheng, A.H.L.Chow, I.S.Haworth. Molecular modeling of flavonoid-b-cyclodextrin complexes.Lett. Drug Des. Disc., 2008, 5, 512-520.
17. K.Li, L.Xu, A.A.Kulkarni, D.I.Perkins, I.S.Haworth, D.L.Davies. Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes. Alcohol Clin. Exp. Res., 2008, 32, 777-784.
18. C.Dowd, B.T.Sutch, I.S.Haworth, R.Eritja, V.E.Marquez, A.S.Yang. Incorporation of zebularine from its 2'-deoxyribonucleoside triphosphate derivative and activity as a template-coding nucleobase. Nucleosid. Nucleotid. & Nucleic Acids, 2008, 27, 131-145.
19. P.Z.Qin, I.S.Haworth, Q.Cai, A.K.Kusnetzow, G.P.G.Grant, E.A.Price, G.Z.Sowa, A.Popova, B.Herreros, H.He. Measuring nanometer distances in nucleic acids using a sequence-independent nitroxide probe. Nature Protocols, 2007, 2, 2354-2365.
20. E.A.Price, B.T.Sutch, Q.Cai, P.Z.Qin, I.S.Haworth. Computation of nitroxide-nitroxide distances in spin-labeled DNA duplexes. Biopolymers, 2007, 87, 40-50.
21. Q.Cai, A.K.Kusnetzow, K.Hideg, E.A.Price, I.S.Haworth, P.Z.Qin. Nanometer distance measurements in RNA using site-directed spin labeling. Biophys. J., 2007, 93, 2110-2117.
22. A.J.Schiewe, I.S.Haworth. Structure-based prediction of MHC-peptide association: algorithm comparison and application to cancer vaccine design. J. Mol. Graph. Model., 2007, 26, 667-675.
23. J.L.S.Links, A.A.Kulkarni, D.L.Davies, V.H.L.Lee, I.S.Haworth. Cysteine scanning of transmembrane domain three of the human dipeptide transporter: implications for substrate transport. J. Drug Targeting, 2007, 15, 218-25.
24. H-H.Bui, A.J.Schiewe, I.S.Haworth. WATGEN: an algorithm for modeling water networks at protein-protein interfaces. J. Comp. Chem., 2007, 28, 2241-2251.
25. A.A.Kulkarni, D.L.Davies, J.S.Links, L.N. Patel, V.H.L.Lee, I.S.Haworth. A charge pair interaction between Arg282 in transmembrane segment 7 and Asp341 in transmembrane segment 8 of the human dipeptide transporter hPepT1. Pharm. Res., 2007, 24, 66-72.
26. Q.Cai, A.K.Kusnetzow, W.L.Hubbell, I.S.Haworth, G.P.C.Gacho, N.van Eps, K.Hideg, E.J.Chambers,, P.Z.Qin. Site-directed spin labeling measurements of nanometer distances in nucleic acids using a sequence-independent nitroxide probe. Nucleic Acids Res., 2006, 34, 4722-4730.
27. M.J.Law, M.E.Linde, E.J.Chambers, C.Oubridge, P.S.Katsamba, L.Nillson, I.S.Haworth, I.A.Laird-Offringa. The role of positively charged amino acids and electrostatic interactions in the complex of U1A protein and U1 hairpin II RNA. Nucleic Acids Res., 2006, 34, 275-85.
28. H-H.Bui, A.J.Schiewe, H.von Grafenstein, I.S.Haworth. Structural prediction of peptides binding to mhc class i molecules. Proteins, 2006, 63, 43-52.
29. M.J.Law, E.J.Chambers, P.S.Katsamba, I.S.Haworth, I.A.Laird-Offringa. Kinetic analysis of the role of the tyrosine 13, phenylalanine 56, and glutamine 54 network in the U1A/U1 hairpin II interaction. Nucleic Acids Res., 2005, 33, 2917-2928.
30. S.C.Raghavan, P.Chastain, J.S.Lee, S.Houston, B.G.Hegde, R.Langen, C-L.Hsieh, I.S.Haworth, M.R.Lieber. Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation. J. Biol. Chem., 2005, 280, 22749-22760.
31. Y.Zheng, I.S.Haworth, Z.Zuo, M.S.S.Chow, A.H.L.Chow. Physicochemical and structural characterization of quercetin-β-cyclodextrin complexes. J. Pharm. Sci., 2005, 94, 1079-1089.
32. K.Yu, D. Roy, M.Bayramyan, I.S.Haworth, M.R.Lieber. Fine-structural analysis of activation-induced deaminase accessibility to class switch region R-loops. Mol. Cell. Biol., 2005, 25, 1730-1736.
33. S.C.Raghavan, S.Houston, B.G.Hegde, R.Langen, I.S.Haworth, M.R.Lieber. Stability and strand asymmetry in the non-B DNA structure at the bcl-2 major breakpoint region. J. Biol. Chem., 2004, 279, 46213-46225.
34. A.A.Kulkarni, I.S.Haworth, T.Uchiyama, V.H.L.Lee. Analysis of transmembrane segment 7 of the dipeptide transporter hPepT1 by cysteine scanning mutagenesis. J. Biol. Chem., 2003, 278, 51833-51840.
35. A.A.Kulkarni, I.S.Haworth, V.H.L.Lee. Transmembrane segment 5 of the dipeptide transporter hPepT1 is an amphipathic helix that forms part of the substrate translocation pathway. Biochem. Biophys. Res. Commun., 2003, 21, 111-125.
36. E.J.Chambers, E.A.Price, M.Z.Bayramyan, I.S.Haworth. Computation of DNA backbone conformations. J. Biomol. Struct. Dyn., 2003, 306, 177-185.
37. P.S.Katsamba, M.Z.Bayramyan, I.S.Haworth, D.G.Myszka, 3 loop in the interaction of U1Ab2-bI.A.Laird-Offringa. Complex role of the with U1 hairpin II RNA. J. Biol. Chem., 2002, 277, 33267-33274.
38. P. Rojsitthisak, R.M.Romero, I.S.Haworth. Extrahelical cytosine bases in DNA Duplexes containing d[GCC]n·d[GCC]nrepeats: detection by a mechlorethamine crosslinking reaction. Nucleic Acids Res., 2001, 29, 4716-4723.
39. R.M.Romero, P. Rojsitthisak, I.S.Haworth. DNA Interstrand crosslink formation by mechlorethamine at a cytosine-cytosine mismatch pair: kinetics and sequence dependence. Arch. Biochem. Biophys., 2001, 386, 143-153.
40. A.Rodger, K.J.Sanders, M.J.Hannon, I.Meistermann, A.Parkinson, D.S.Vidler, I.S.Haworth. DNA structure control by polycationic species: polyamine, cobalt ammines, and di-metallo transition metal chelates. Chirality, 2000, 12, 221-236.
41. W.S.Meng, H.von Grafenstein and I.S.Haworth. Water dynamics at the HLA-A2 / peptide interface. International Immunology, 2000, 12, 949-957.
42. W. S. Meng, H-H. Bui, I.S.Haworth. Exploiting the peptide-MHC water interface in the computer-aided design of non-natural peptides that bind to the class I MHC molecule HLA-A2. Molecular Simulation, 2000, 24, 215-229.

Profile Details

https://mann.usc.edu/faculty/ian-s-haworth-phd/

https://www.researchgate.net/profile/Ian-Haworth

https://orcid.org/0000-0002-3873-0899