Dr. Steven E. Mutsaers

University of Western Australia

Associate Professor

Email: [email protected]

Qualifications

1993 Ph.D., Department of Pathology, University of Western Australia, Australia

1986 B.Sc., Department of Pathology, University of Western Australia, Australia

Publications (selected)

1. Behrouzfar, Kiarash & Mutsaers, Steven & Chin, Wee Loong & Patrick, Kimberley & Ng, Isaac & Pixley, Fiona & Morahan, Grant & Lake, Richard & Fisher, Scott. (2024). Mesothelioma survival prediction based on a six-gene transcriptomic signature. iScience. 27. 111011. 10.1016/j.isci.2024.111011.

2. Mackintosh, John & Keir, Gregory & Troy, Lauren & Holland, Anne & Grainge, Christopher & Chambers, D. & Sandford, Debra & Jo, Helen & Glaspole, Ian & Wilsher, Margaret & Goh, Nicole & Reynolds, Paul & Chapman, Sally & Mutsaers, Steven & Boer, Sally & Webster, Susanne & Moodley, Yuben & Corte, Tamera. (2024). Treatment of idiopathic pulmonary fibrosis and progressive pulmonary fibrosis: A position statement from the Thoracic Society of Australia and New Zealand 2023 revision. Respirology. 29. 10.1111/resp.14656.

3. Mutsaers, Steven & Miles, Tylah & Prêle, Cecilia & Hoyne, Gerard. (2023). Emerging role of immune cells as drivers of pulmonary fibrosis. Pharmacology & Therapeutics. 252. 108562. 10.1016/j.pharmthera.2023.108562.

4. Prêle, Cecilia & Miles, Tylah & Pearce, David & O'Donoghue, Robert & Grainge, Chris & Barrett, Lucy & Birnie, Kimberly & Lucas, Andrew & Baltic, Svetlana & Ernst, Matthias & Rinaldi, Catherine & Laurent, Geoffrey & Fear, Mark & Hoyne, Gerard & Mcanulty, Robin & Mutsaers, Steven. (2022). Plasma cell but not CD20-mediated B cell depletion protects from bleomycin-induced lung fibrosis. European Respiratory Journal. 60. 2101469. 10.1183/13993003.01469-2021.

5. Mutsaers, Steven & Herrick, Sarah. (2022). Mesothelial Cells. Encyclopedia of Respiratory Medicine (Second Edition). 58-66. 10.1016/B978-0-08-102723-3.00075-5.                                                              

6. Schuliga, Michael & Kanwal, Amama & Read, Jane & Blokland, Kaj & Burgess, Janette & Prêle, Cecilia & Mutsaers, Steven & Grainge, Christopher & Thomson, Claire & James, Allen & Bartlett, Nathan. (2021). A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: A potential drug target in IPF. American Journal of Physiology-Lung Cellular and Molecular Physiology. 321. 10.1152/ajplung.00574.2020.

7. Waters, David & Schuliga, Michael & Pathinayake, Prabuddha & Wei, Lan & Tan, Hui-Ying & Blokland, Kaj & Jaffar, Jade & Westall, Glen & Burgess, Janette & Prêle, Cecilia & Mutsaers, Steven & Grainge, Christopher. (2021). A Senescence Bystander Effect in Human Lung Fibroblasts. Biomedicines. 9. 10.3390/biomedicines9091162.

8. Behrouzfar, Kiarash & Burton, Kimberley & Mutsaers, Steven & Morahan, Grant & Lake, Richard & Fisher, Scott. (2021). How to Better Understand the Influence of Host Genetics on Developing an Effective Immune Response to Thoracic Cancers. Frontiers in Oncology. 11. 10.3389/fonc.2021.679609.

9. Prêle, Cecilia & Iosifidis, Thomas & Mcanulty, Robin & Pearce, David & Badrian, Bahareh & Miles, Tylah & Jamieson, Sarra & Ernst, Matthias & Thompson, Philip & Laurent, Geoffrey & Mutsaers, Steven. (2021). Reduced SOCS1 Expression in Lung Fibroblasts from Patients with IPF Is Not Mediated by Promoter Methylation or Mir155. Biomedicines. 9. 10.3390/biomedicines9050498.

10. Miles, Tylah & Hoyne, Gerard & Fear, Mark & Mutsaers, Steven & Prêle, Cecilia. (2020). The contribution of animal models to understanding the role of the immune system in human idiopathic pulmonary fibrosis. Clinical & Translational Immunology. 9. 10.1002/cti2.1153.

11. Deng, Zhenjun & Fear, Mark & Choi, Yu Suk & Wood, Fiona & Allahham, Amira & Mutsaers, Steven & Prêle, Cecilia. (2020). The extracellular matrix and mechanotransduction in pulmonary fibrosis. The International Journal of Biochemistry & Cell Biology. 126. 105802. 10.1016/j.biocel.2020.105802.

12. Mutsaers, Steven & Pixley, Fiona & Prêle, Cecilia & Hoyne, Gerard. (2020). Mesothelial cells regulate immune responses in health and disease: role for immunotherapy in malignant mesothelioma. Current Opinion in Immunology. 64. 88-109. 10.1016/j.coi.2020.04.005.

13. Blokland, Kaj & Waters, David & Schuliga, Michael & Read, Jane & Pouwels, Simon & Grainge, Christopher & Jaffar, Jade & Westall, Glen & Mutsaers, Steven & Prêle, Cecilia & Burgess, Janette. (2020). Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing. Pharmaceutics. 12. 389. 10.3390/pharmaceutics12040389.

14. Schuliga, Michael & Read, Jane & Blokland, Kaj & Waters, David & Burgess, Janette & Prele, Cecilia & Mutsaers, Steven & Jaffar, Jade & Westall, Glen & Reid, Andrew & James, Allen & Grainge, Christopher. (2020). Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner. Clinical Science. 134. 10.1042/CS20191160.

15. Blokland, Kaj & Waters, David & Schuliga, Michael & Pouwels, Simon & Grainge, Chris & Mutsaers, Steven & Prêle, Cecilia & Westall, Glenn & Jaffar, Jade & Knight, Darryl & Burgess, Janette. (2019). Alveolar epithelial wound repair is delayed by scenescent lung fibroblasts in IPF. PA596. 10.1183/13993003.congress-2019.PA596.

16. Birnie, Kimberly & Prêle, Cecilia & Musk, Arthur & Klerk, Nick & Lee, Y C Gary & Fitzgerald, Deirdre & Allcock, Richard & Thompson, Philip & Creaney, Jenette & Badrian, Bahareh & Mutsaers, Steven. (2019). MicroRNA Signatures in Malignant Pleural Mesothelioma Effusions. Disease Markers. 2019. 1-9. 10.1155/2019/8628612.

17. Abayasiriwardana, Keith & Wood, Michael & Prêle, Cecilia & Birnie, Kimberly & Robinson, Bruce & Laurent, Geoffrey & Mcanulty, Robin & Mutsaers, Steven. (2019). Inhibition of collagen production delays malignant mesothelioma tumor growth in a murine model. Biochemical and Biophysical Research Communications. 510. 10.1016/j.bbrc.2019.01.057.

18. Waters, David & Blokland, Kaj & Pathinayake, Prabuddha & Wei, Lan & Schuliga, Michael & Jaffar, Jade & Westall, Glen & Hansbro, Philip & Prele, Cecilia & Mutsaers, Steven & Bartlett, Nathan & Burgess, Janette & Grainge, Christopher. (2019). STAT3 Regulates the Onset of Oxidant-Induced Senescence in Lung Fibroblasts. American Journal of Respiratory Cell and Molecular Biology. 61. 10.1165/rcmb.2018-0328OC.

19. Celada, Lindsay & Kropski, Jon & Herazo-Maya, Jose & Luo, Weifeng & Creecy, Amy & Abad, Touraj & Chioma, Ozioma & Lee, Grace & Hassell, Natalie & Shaginurova, Guzel & Wang, Yufen & Johnson, Joyce & Kerrigan, Amy & Mason, Wendi & Baughman, Robert & Ayers, Gregory & Bernard, Gordon & Culver, Daniel & Montgomery, Courtney & Drake, Wonder. (2018). PD-1 up-regulation on CD4 + T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production. Science Translational Medicine. 10. eaar8356. 10.1126/scitranslmed.aar8356.

20. Schuliga, Michael & Pechkovsky, Dmitri & Read, Jane & Waters, David & Blokland, Kaj & Reid, Andrew & Hogaboam, Cory & Khalil, Nasreen & Burgess, Janette & Prêle, Cecilia & Mutsaers, Steven & Jaffar, Jade & Westall, Glen & Grainge, Christopher. (2018). Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts. Journal of Cellular and Molecular Medicine. 22. 10.1111/jcmm.13855.

Profile Details

https://scholar.google.com.au/citations?user=YHGhSaoAAAAJ&hl=en

https://www.researchgate.net/profile/Steven-Mutsaers