Dr. Liping Huang

USDA/ARS/Western Human Nutrition Research Center, USA

Department of Nutrition, University of California Davis, USA

Email: [email protected]

Qualifications

1995-1999 Postdoctoral fellow, Molecular genetics, Howard Hughes Medical Institute, University of California, San Franciso, USA

1989-1995 Ph.D. Molecular virology, College of Medicine, University of Iowa, USA

1978-1983 M.D. Medicine and public health, Shanghai Medical University, Shanghai, P.R. China

Publications (selected)

1. Huang, L, Gitschier, J. A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nat. Genet. 17:292-297, 1997.
2. Kirschke, C.P., Huang, L.* ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus. J. Biol. Chem. 278:4096-102, 2003.
3. Huang, L., Kirschke, C.P., Zhang, Y., Yu, Y.Y. The ZIP7 Gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. J. Biol. Chem. 280:15456-15463, 2005.
4. Huang, L., Kirschke, C.P., Zhang, Y. Decreased intracellular zinc in human tumorigenic prostate epithelial cells: a possible role in prostate cancer progression. Cancer Cell Int. 31:6:10, 2006.
5. Huang, L., Yu, Y.Y., Kirschke, C.P., Gertz, E.R., Lloyd, K.K. Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation. J. Biol. Chem. 282:37053-37063, 2007.
6. Kirschke, C.P., Huang, L. Expression of ZNT (SLC30) family members in the epithelium of the mouse prostate during sexual maturation. J. Mol. Histol. 39:359-370, 2008.
7. Huang, L., Yan, M., Kirschke, C.P. Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic β-cells by promoting insulin gene transcription. Exp. Cell Res. 316:2630-43, 2010.
8. Tepaamorndech, S., Huang, L., Kirschke, C.P. A null-mutation in the Znt7 gene accelerates prostate tumor formation in a transgenic adenocarcinoma mouse prostate model. Cancer Lett. 308:33-42, 2011.
9. Huang, L., Kirschke, C.P., Lay, Y.E., Levy, L.B., Lamirande, D.E., Zhang, P.H. Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance. J. Biol. Chem. 287:33883-33896, 2012.
10. Huang, L., Tepaamorndech, S. The SLC30 family of zinc transporters – A review of current understanding of their biological and pathophysiological roles. J. Mol. Aspects Med. 34:548-560, 2013.
11. Tepaamorndech, S., Kirschke, C.P., Huang, L. Linking cellular zinc status to body weight and fat mass: mapping quantitative trait loci in Znt7 knockout mice. Mamm. Genome. 25:335-353, 2014.
12. Tepaamorndech S, Kirschke CP, Pedersen TL, Keyes WR, Newman JW, Huang L. Zinc transporter 7 deficiency affects lipid synthesis in adipocytes by inhibiting insulin-dependent Akt activation and glucose uptake. FEBS J. 283:378-394, 2016.
13. Huang, L. and Kirschke, C.P. Down-regulation of zinc transporter 8 (SLC30A8) in pancreatic beta-cells promotes cell survival. Austin J. Edocrinol. Diabetes, 3:1037, 2016.
14. Tepaamorndech, S., Ooat, P., Kirschke, C.P., Cai, Y.M., Huang, L. ZNT7 binds to CD40 and influences CD154-triggered p38 MAPK activity in B lymphocytes: a possible regulatory mechanism for zinc in immune function FEBS Open Bio. 7:675-690, 2017.
15. Cai, Y., Kirschke, C.P., Huang, L. SLC30A family expression in the pancreatic islets of humans and mice: cellular localization in the β-cells. J. Mol. Histol. 49:133-145, 2018.
16. Huang L, Tepaamorndech S, Kirschke CP, Newman JW, Keyes WR, Pedersen TL, Dumnil J. Aberrant fatty acid metabolism in skeletal muscle contributes to insulin resistance in zinc transporter 7 (Znt7)-knockout mice J. Biol. Chem. 293:7549-7563, 2018.
17. Huang L, Tepaamorndech S, Kirschke CP, Cai Y, Zhao J, Cao X, Rao A. Subcongenic analysis of a quantitative trait locus affecting body weight and glucose metabolism in zinc transporter 7 (znt7)-knockout mice. BMC Genet. 20:19, 2019.
18. Kable ME, Riazati N, Kirschke CP, Zhao J, Tepaamorndech S, Huang L. The Znt7-null mutation has sex dependent effects on the gut microbiota and goblet cell population in the mouse colon. PLoS One.15(9):e0239681. 2020.
19. Wang YE, Kirschke CP, Woodhouse LR, Bonnel EL, Stephensen CB, Bennett BJ, Newman JW, Keim NL, Huang L. SNPs in apolipoproteins contribute to sex-dependent differences in blood lipids before and after a high-fat dietary challenge in healthy U.S. adults. BMC Nutr. 8:95, 2022.
20. James KL, Gertz, ER, Kirschke CP, Allayee H, Huang L, Kable ME, Newman JW, Stephensen CB, Bennett BJ. Trimethylamine N-oxide response to a mixed macronutrient tolerance test in a cohort of healthy United States adults. Int. J. Mol. Sci. 24:2074, 2023.
21. Huang, L. Yang, Z., Kirschke, C. P., Prouteau, C., Copin, M.-C., Bonneau, D., Pellier, I., Coutant, R., Miot, C., and Ziegler, A. Identification of novel compound heterozygous variants in the SLC30A7 (ZNT7) gene in two French brothers with stunted growth, testicular hypoplasia, and bone marrow failure. Human Mol. Genet. 32:2016-2031, 2023.
22. Yang, Z., Wang, Y. E., Kirschke, C. P., Stephensen, C. B. Newman, J. W., Keim, N. L., Cai, Y., and Huang, L*. Effects of a Genetic Variant Rs13266634 in the Zinc Transporter 8 Gene (Slc30a8) on Insulin and Lipid Levels Before and after a High-Fat Mixed Macronutrient Tolerance Test in Healthy U.S. Adults. J. Trace Elem. in Med. & Biol. 77:127142, 2023.
23. Yang, Z., Kirschke, C. P., Cai, Y., and Huang, L*. A double knockout for zinc transporter 8 and somatostatin in mice reveals their distinct roles in regulation of insulin secretion and obesity. Genes & Nutrition, 2024, in press.

Personal Profile

https://www.ars.usda.gov/pacific-west-area/davis-ca/whnrc/omu/people/liping-huang/

https://nutrition.ucdavis.edu/people/liping-huang