Dr. Hengye Man

Email: [email protected]

Qualifications

Publications (Selected)

1. Jarzylo LA, Man HY. Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability. J Neurosci. 2012 Feb 15; 32(7):2552-63. PMID: 22396428; DOI: 10.1523/JNEUROSCI.3237-11.2012;
2. Lin AW, Man HY. Ubiquitination of neurotransmitter receptors and postsynaptic scaffolding proteins. Neural Plast. 2013; 2013:432057. PMID: 23431475; DOI: 10.1155/2013/432057;
3. Wang G, Amato S, Gilbert J, Man HY. Resveratrol up-regulates AMPA receptor expression via AMP-activated protein kinase-mediated protein translation. Neuropharmacology. 2015 Aug; 95:144-53. PMID: 25791529; DOI: 10.1016/j.neuropharm.2015.03.003;
4. Gilbert J, Man HY. The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and d-Catenin Signaling. eNeuro. 2016 Sep-Oct; 3(5). PMID: 27822498; DOI: 10.1523/ENEURO.0238-16.2016;
5. Wang G, Li S, Gilbert J, Gritton HJ, Wang Z, Li Z, Han X, Selkoe DJ, Man HY. Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory. Cell Rep. 2017 08 08; 20(6):1335-1347.View Related Profiles. PMID: 28793258; DOI:
6. Khatri N, Gilbert JP, Huo Y, Sharaflari R, Nee M, Qiao H, Man HY. The Autism Protein Ube3A/E6AP Remodels Neuronal Dendritic Arborization via Caspase-Dependent Microtubule Destabilization. J Neurosci. 2018 01 10; 38(2):363-378.View Related Profiles. PMID: 29175955; DOI:
7. Keaveney MK, Tseng HA, Ta TL, Gritton HJ, Man HY, Han X. A MicroRNA-Based Gene-Targeting Tool for Virally Labeling Interneurons in the Rodent Cortex. Cell Rep. 2018 07 10; 24(2):294-303.View Related Profiles. PMID: 29996091; DOI: 10.1016/j.celrep.2018.06.049;
8. Wang G, Zhong J, Guttieres D, Man HY. Non-scaling regulation of AMPA receptors in homeostatic synaptic plasticity. Neuropharmacology. 2019 11 01; 158:107700. PMID: 31283924; DOI: 10.1016/j.neuropharm.2019.107700;
9. Hastings MH, Gauthier JM, Mabry K, Tran A, Man HY, Kantak KM. Facilitative effects of environmental enrichment for cocaine relapse prevention are dependent on extinction training context and involve increased TrkB signaling in dorsal hippocampus and ventromedial prefrontal cortex. Behav Brain Res. 2020 05 27; 386:112596.View Related Profiles. PMID: 32194188; DOI: 10.1016/j.bbr.2020.112596;
10. O'Connor M, Shentu YP, Wang G, Hu WT, Xu ZD, Wang XC, Liu R, Man HY. Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease. iScience. 2020 Sep 25; 23(9):101465. PMID: 32861999; DOI: 10.1016/j.isci.2020.101465;
11. Shi L, Jiang Y, Fernandez FR, Chen G, Lan L, Man HY, White JA, Cheng JX, Yang C. Non-genetic photoacoustic stimulation of single neurons by a tapered fiber optoacoustic emitter. Light Sci Appl. 2021 Jul 14; 10(1):143.View Related Profiles. PMID: 34257273; DOI: 10.1038/s41377-021-00580-z;
12. Huo Y, Lu W, Tian Y, Hou Q, Man HY. Prkn knockout mice show autistic-like behaviors and aberrant synapse formation. iScience. 2022 Jul 15; 25(7):104573. PMID: 35789851; DOI: 10.1016/j.isci.2022.104573;
13. Qiao H, Tian Y, Huo Y, Man HY. Role of the DUB enzyme USP7 in dendritic arborization, neuronal migration, and autistic-like behaviors in mice. iScience. 2022 Jul 15; 25(7):104595. PMID: 35800757; DOI: 10.1016/j.isci.2022.104595;
14. O'Connor M, Qiao H, Odamah K, Cerdeira PC, Man HY. Heterozygous Nexmif female mice demonstrate mosaic NEXMIF expression, autism-like behaviors, and abnormalities in dendritic arborization and synaptogenesis. Heliyon. 2024 Feb 15; 10(3):e24703. PMID: 38322873; DOI: 10.1016/j.heliyon.2024.e24703;
15. Tian Y, Yu F, Yun E, Lin JW, Man HY. mRNA nuclear retention reduces AMPAR expression and promotes autistic behavior in UBE3A-overexpressing mice. EMBO Rep. 2024 Mar; 25(3):1282-1309. PMID: 38316900; DOI: 10.1038/s44319-024-00073-1;
16. Qingming Hou, James Gilbert and Heng-Ye Man(2011) Regulation of AMPA receptor trafficking and stability at single synapses by light-controlled presynaptic activation. Neuron, in press.
17. S Amato, X Liu, B Zheng, L Cantley, P Rakic, H Y Man (2011) AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization. Science, 332(6026):247-51.
18. Heng-Ye Man (2011) GluA2-lacking, calcium-permeable AMPA receptors-inducers of plasticity? (Invited review)Current Opinion in Neurobiology 21 (1): 1-8.
19. A Lin, Q Hou, L Jarzylo, S Amato, J Gilbert, F Shang and H Y Man (2011)Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking. J. Neurochemistry, 117 (5), 614-625.
20. Stephen Amato and Heng-Ye Man (2011) AMPK links cellular bioenergy status to the decision making of axon initiation in neurons (Invited review)Cellular Logistics1(3): 103-1054.
21. Stephen Amato and Heng-Ye Man (2011) Bioenergy sensing in the brain: the role of AMP-activated protein kinase in neuronal metabolism, development and neurological diseases. (Invited review)CellCycle, 10 (20).
22. D Zhang, Q Hou, M Wang, A Lin, A Navis, A Raissi, F Liu andH Y Man(2009) Na, K-ATPase activity regulates AMPA receptor turnover through proteasome-mediated proteolysis. J Neurosci 29 (14): 4498-4511.
23. J Oberlander, A Lin,H Y Man, and M Erskine (2009) AMPA receptors in the medial amygdala are critical for establishing a neuroendocrine memory in the female rat. Eur J Neurosci 29(1):146-60.
24. Q Hou, Y Huang, S Amato, S H Snyder, R L Huganir,H Y Man(2008) Regulation of AMPA receptor localization in lipid rafts. Mol. Cel. Neurosci38 (2): 213-223.
25. Q Hou, D Zhang, L Jarzylo, R L Huganir,H Y Man(2008) Homeostatic regulation of AMPA receptor expression at single hippocampal synapses.Proc Natl Acad Sci U S A 105(2):775-80.
26. B B Andken, I Lim, G Benson, J J Vincent, M T Ferenc, B Heinrich, L A Jarzylo, H Y Man, J O Deshler (2007) 3'-UTR SIRF: a database for identifying clusters of whort interspersed repeats in 3' untranslated regions. BMC Bioinformatics 30; 8:274.
27. H Y Man, Y Sekine-Aizawa, and R L. Huganir (2007) Regulation of-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit. Proc Natl Acad Sci U S A 104 (9), 3579-3584.
28. Y Huang, H Y Man, Y Sekine-Aizawa, Y Han, K Juluri, H Luo, J Cheah, C Lowenstein, R L Huganir and S H Snyder (2005) S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron 46(4):533-40.
29. H Y Man, Q H Wang, W Y Lu, W Ju, G Amardian, S D’Souza, L D Liu, T P Wong, LE Becker, L Pai, F Liu, M P Wymann, JF MacDonald and YT Wang (2003)Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons. Neuron 37, 611-624.
30. H Y Lee, K Takamiya, J S Han, H Y Man, C H Kim, G Rumbaugh, S Yu, L Ding, C He, R S Petralia, R J Wenthold, M Gallagher and R L Huganir (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112, 631-643.
31. W Y Lu*, H Y Man*, W Ju, W Trimble, Y T Wang and John F MacDonald (2001)Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. (*Equal contribution)  Neuron 29, 243–254.
32. R Q Hu, M A Cortez, H Y Man, J Roder, Y T Wang and O C Snead III (2001) Alteration of GluR2 expression in the rat brain following absence seizures induced by -hydroxybutyric acid. Epilepsy Research44(1), 41-51.
33. R Q Hu, M A Cortez, H Y Man, J Roder, Z P Jia, Y T Wang and O C Snead III (2001) GHB-induced absence seizures in GluR2 null mutant mice.  Brain Research897 (1-2): 27-35.
34. H Y Man, J Lin, W Ju, G Ahmadian, L Liu, L E Becker, M Sheng and Y T Wang (2000) Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization.Neuron 25:649-662.
35. H Y Man, W Ju, G Ahmadian and Y T Wang (2000) Intracellular trafficking of AMPA receptors in synaptic plasticity. (Review). Molecular and Cellular Life Science 57 (11): 1526-1534.
36. D I McRitchie, N Isowa, J D Edelson, A M Xavier, L Cai L,H Y Man, Y T Wang, S H Keshavjee, A S Slutsky, M Liu (2000)Production of tumour necrosis factor alpha by primary cultured rat alveolar epithelial cells. Cytokine 12(6):644-54.
37. Q Wan, H Y Man, F Liu, J Braunton, H B Niznik, S F Pang, G M Brown and Y T Wang (1999) Differential modulation of GABAAreceptor function by Mel1aand Mel1breceptors. Nature Neuroscience2 (5):401-403.
38. H Y Man, E Ted, L E Becker and Y T Wang (1998) Modulation of baroreflex sensitivity by the state of tyrosine phosphorylation in the brainstem of rat. Brain Research792:141-148.
39. Z B Pristupa, F McConkey, F Liu, H Y Man, F J S Lee, Y T Wang and H B Niznik (1998) Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter. Synapse 30:79-87.
40. Q Wan, H Y Man, J Braunton, W Wang, M W Salter, L Becker and Y T Wang (1997) Modulation of GABAA receptor function by tyrosine phosphorylation of b subunits. J Neurosci17(13): 5062-5069.
41. Q Wan, Z G Xiong, H Y Man, C A Ackerley, J Brauton, L E Becker, J F MacDonald and Y T Wang (1997). Recruitment of functional GABAA receptors to postsynaptic domains by insulin. Nature 388:686-690.
42. H Y Man and L Lui (1992) Effect of electrical and L-glutamate stimulation of nucleus raphe obscurus on phrenic nerve activity in rabbits. Acta Physiologica Sinica44 (1): 92-97.
43. Y Q Zhang, H Y Man and L Liu (1991) Respiratory effects of microinjection of three kinds of neurotransmitters in vertromedial region of nucleus facialis. Acta Physiologica Sinica43 (6): 594-599.

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