Prof. Hee-Jeong Im Sampen

Departments of Biochemistry

Rush University Medical Center, USA

Associate Professor

Email: [email protected]

Qualifications

2014-Present Professor, Jesse Brown VA Hospital, USA

2012-Present Professor, Rush University Medical Center, USA

2008-2012 Associate Professor, Rush University Medical Center, USA

2003-2007 Assistant Professor, Rush University Medical Center, USA

1997-2000 Postdoctoral Research Associate, University of Minnesota, USA

1992-1996 Ph.D., University of New South Wales, Australia, Biotechnolgy

1990-1991 M.S., University of New South Wales, Australia, Microbiology

Publications (selected)

1. Shih, Sunny & Grant, Michael & Epure, Laura & Alad, Muskan & Lerouge, Sophie & Huk, Olga & Bergeron, Stephane & Zukor, David & Merle, Geraldine & Im, Hee-Jeong & Antoniou, John & Mwale, Fackson. (2024). Advances in the Regulation of Periostin for Osteoarthritic Cartilage Repair Applications. Biomolecules. 14. 1469. 10.3390/biom14111469.

2. Alad, Muskan & Grant, Michael & Epure, Laura & Shih, Sunny & Merle, Geraldine & Im, Hee-Jeong & Antoniou, John & Mwale, Fackson. (2024). Short Link N Modulates Inflammasome Activity in Intervertebral Discs Through Interaction with CD14. Biomolecules. 14. 1312. 10.3390/biom14101312.

3. Yan, Dongyao & Chen, Di & Cool, Simon & Wijnen, Andre & Mikecz, Katalin & Murphy, Gillian & Im, Hee-Jeong. (2024). Retraction Note: Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes. Arthritis Research & Therapy. 26. 10.1186/s13075-024-03381-y.

4. Sampen, Hee & Im, Hee-Jeong & Sharrocks, Andrew & Lin, Xia & Yan, Dongyao & Kim, Jae-Sung & Wijnen, Andre & Hipskind, Robert. (2024). Basic Fibroblast Growth Factor Induces Matrix Metalloproteinase-13 via ERK MAP Kinase-Altered Phosphorylation and Sumoylation of Elk-1 in Human Adult Articular Chondrocytes [Expression of Concern]. Open Access Rheumatology: Research and Reviews. Volume 16. 87-88. 10.2147/OARRR.S478378.

5. Ma, Kaige & Pham, Tiep & Wang, Jun & o-sullivan, Insug & DiCamillo, Amy & Du, Shiyu & Mwale, Fackson & Farooqui, Zeba & votta-velis, Effrossyni & Bruce, Benjamin & Wijnen, Andre & Liu, Ying & Im, Hee-Jeong. (2024). Nanoparticle-based inhibition of vascular endothelial growth factor receptors alleviates osteoarthritis pain and cartilage damage. Science advances. 10. eadi5501. 10.1126/sciadv.adi5501.                                                  

6. Singh, Gurjit & o-sullivan, Insug & Natarajan Anbazhagan, Arivarasu & Ranjan, K.C. & Farooqui, Zeba & Ma, Kaige & Wang, Jun & Mwale, Fackson & votta-velis, Effrossyni & Bruce, Benjamin & Kahn, C. & Wijnen, Andre & Im, Hee-Jeong. (2023). Loss of PKCδ/Prkcd prevents cartilage degeneration in joints but exacerbates hyperalgesia in an experimental osteoarthritis mouse model. Gene. 893. 147920. 10.1016/j.gene.2023.147920.

7. Dara, Praneet & Farooqui, Zeba & Mwale, Fackson & Choe, Chungyoul & Wijnen, Andre & Im, Hee-Jeong. (2023). Opiate Antagonists for Chronic Pain: A Review on the Benefits of Low-Dose Naltrexone in Arthritis versus Non-Arthritic Diseases. Biomedicines. 11. 1620. 10.3390/biomedicines11061620.                           

8. Ma, Kaige & Singh, Gurjit & Wang, Jun & o-sullivan, Insug & votta-velis, Effrossyni & Bruce, Benjamin & Natarajan Anbazhagan, Arivarasu & Wijnen, Andre & Im, Hee-Jeong. (2023). Targeting Vascular Endothelial Growth Factor Receptors as a Therapeutic Strategy for Osteoarthritis and Associated Pain. International Journal of Biological Sciences. 19. 675-690. 10.7150/ijbs.79125.

9. Singh, Gurjit & o-sullivan, Insug & Natarajan Anbazhagan, Arivarasu & K.C, Ranjan & Farooqui, Zeba & Ma, Kaige & Mwale, Fackson & votta-velis, Effrossyni & Bruce, Benjamin & Kahn, C. & Wijnen, Andre & Im, Hee-Jeong. (2023). Loss of Pkcδ/Prkcd Prevents Cartilage Degeneration in Joints But Exacerbates Hyperalgesia in an Experimental Osteoarthritis Mouse Model. 10.2139/ssrn.4412719.

10. o-sullivan, Insug & kc, Ranjan & Singh, Gurjit & Das, Vaskar & Ma, Kaige & Li, Xin & Mwale, Fackson & votta-velis, Effrossyni & Bruce, Benjamin & Natarajan Anbazhagan, Arivarasu & Wijnen, Andre & Im, Hee-Jeong. (2022). Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (TrkA) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization. International Journal of Molecular Sciences. 23. 12076. 10.3390/ijms232012076.

11. o-sullivan, Insug & Natarajan Anbazhagan, Arivarasu & Singh, Gurjit & Ma, Kaige & Green, Stefan & Singhal, Megha & Wang, Jun & Kumar, Anoop & Dudeja, Pradeep & Unterman, Terry & votta-velis, Effrossyni & Bruce, Benjamin & Wijnen, Andre & Im, Hee-Jeong. (2022). Lactobacillus acidophilus Mitigates Osteoarthritis-Associated Pain, Cartilage Disintegration and Gut Microbiota Dysbiosis in an Experimental Murine OA Model. Biomedicines. 10. 1298. 10.3390/biomedicines10061298.

12. Yun, Heesu & Im, Hee-Jeong & Choe, Chungyoul & Roh, Sangho. (2022). Effect of LOXL2 on metastasis through remodeling of the cell surface matrix in non-small cell lung cancer cells. Gene. 830. 146504. 10.1016/j.gene.2022.146504.

13. Arora, Vipin & Singh, Gurjit & o-sullivan, Insug & Ma, Kaige & Natarajan Anbazhagan, Arivarasu & Gott-Velis, Gina & Bruce, Benjamin & Richard, Ripper & Wijnen, Andre & Im, Hee-Jeong. (2021). Gut-Microbiota Modulation: The Impact of the Gut-Microbiota on Osteoarthritis. Gene. 785. 145619. 10.1016/j.gene.2021.145619.

14. Qiu, Sujun & Shi, Changgui & Natarajan Anbazhagan, Arivarasu & Das, Vaskar & Arora, Vipin & kc, Ranjan & Li, Xin & o-sullivan, Insug & Wijnen, Andre & Chintharlapalli, Sudhakar & Gott‐Velis, Gina & Richard, Ripper & Mwale, Fackson & Shibuya, Masabumi & Min, Shaoxiong & Im, Hee‐Jeong. (2019). Absence of VEGFR‐1/Flt‐1 signaling pathway in mice results in insensitivity to discogenic low back pain in an established disc injury mouse model. Journal of Cellular Physiology. 235. 10.1002/jcp.29416.

15. Singhal, Megha & Arora, Vipin & Im, Hee-Jeong. (2019). Gastrointestinal disorders-induced pain. Gene Reports. 18. 100580. 10.1016/j.genrep.2019.100580.

16. Das, Vaskar & kc, Ranjan & Li, Xin & o-sullivan, Insug & Im, Hee-Jeong. (2019). Title: Identification of new drug targets for the treatment of osteoarthritis and joint pain: VEGF and VEGFRs.

17. Shi, Changgui & Wu, Lecheng & Lin, Wenbo & Cai, Yuanqi & Zhang, Ying & Hu, Bo & Gao, Rui & Wijnen, Andre & Yuan, Wen & Ye, Xiaojian & Im, Hee-Jeong. (2019). Corrigendum to “Mir-202-3p regulates interleukin-1β-induced expression of matrix metalloproteinase 1 in human nucleus pulposus” [Gene 687 (2019) 156–165]. Gene. 696. 10.1016/j.gene.2019.01.030.

18. Shi, Changgui & Wu, Lecheng & Lin, Wenbo & Cai, Yuanqi & Zhang, Ying & Hu, Bo & Gao, Rui & Im, Hee-Jeong & Yuan, Wen & Ye, Xiaojian & Wijnen, Andre. (2018). MiR-202-3p regulates interleukin-1β-induced expression of matrix metalloproteinase 1 in human nucleus pulposus. Gene. 687. 10.1016/j.gene.2018.11.056.                                                             

19. Camilleri, Emily & Dudakovic, Amel & Riester, Scott & Galeano Garces, Catalina & Paradise, Christopher & Bradley, Elizabeth & McGee-Lawrence, Meghan & Im, Hee-Jeong & Karperien, Marcel & Krych, Aaron & Westendorf, Jennifer & Larson, Annalise & Wijnen, Andre. (2018). Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development. Journal of Biological Chemistry. 293. jbc.RA118.003909. 10.1074/jbc.RA118.003909.

20. Shi, Changgui & Wu, Huiqiao & Du, Di & Im, Hee-Jeong & Zhang, Ying & Hu, Bo & Chen, Huajiang & Wang, Xinwei & Liu, Yang & Cao, Peng & Tian, Ye & Shen, Xiaolong & Gao, Rui & Wijnen, Andre & Ye, Xiaojian & Yuan, Wen. (2018). Nicotinamide Phosphoribosyltransferase Inhibitor APO866 Prevents IL-1β-Induced Human Nucleus Pulposus Cell Degeneration via Autophagy. Cellular Physiology and Biochemistry. 49. 2463-2482. 10.1159/000493843.

Profile Details

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