Prof. Firoze Khan
The University of Texas Medical Branch, USA
Email: mfkhan@utmb.edu
Qualifications
1983 Ph.D., Biochemistry, Industrial Toxicology Research Centre, Lucknow & Aligarh Muslim. University (AMU), India
1980 M.Sc., Biochemistry, Central Drug Research Institute. Lucknow & AMU, Aligarh, India
1978 M.Sc., Biochemistry AMU, India
1976 B.Sc., Chemistry, AMU, Aligarh, India
Publications (selected)
1. Abdelgadir, Omer & Kuo, Yong-Fang &
Okorodudu, Anthony & Khan, M Firoze & Cheng, Yu-Wei & Dong, Jianli.
(2025). KRAS, NRAS, and BRAF Hot-Spot Mutations in Relation to Sidedness of
Primary Colorectal Cancer: A Retrospective Cohort Study. Diagnostics. 15. 142.
10.3390/diagnostics15020142.
2. Wang, Hui & Banerjee, Nivedita & Wang, Gangduo &
Khan, M Firoze. (2023). Autophagy dysregulation in trichloroethene-mediated
inflammation and autoimmune response. Toxicology. 487. 153468.
10.1016/j.tox.2023.153468.
3. Banerjee, Nivedita & Wang, Hui & Wang, Gangduo &
Boor, Paul & Khan, M Firoze. (2022). Differential Expression of miRNAs in
Trichloroethene-Mediated Inflammatory/Autoimmune Response and Its Modulation by
Sulforaphane: Delineating the Role of miRNA-21 and miRNA-690. Frontiers in
Immunology. 13. 10.3389/fimmu.2022.868539.
4. Wang, Hui & Banerjee, Nivedita & Liang, Yuejin &
Wang, Gangduo & Hoffman, Kristi & Khan, M Firoze. (2021). Gut
microbiome-host interactions in driving environmental pollutant
trichloroethene-mediated autoimmunity. Toxicology and Applied Pharmacology.
424. 115597. 10.1016/j.taap.2021.115597.
5. Wang, Hui & Wang, Gangduo & Banerjee,
Nivedita & Liang, Yuejin & Du, Xiaotang & Boor, Paul & Hoffman,
Kristi & Khan, M Firoze. (2021). Aberrant Gut Microbiome Contributes to
Intestinal Oxidative Stress, Barrier Dysfunction, Inflammation and Systemic
Autoimmune Responses in MRL/lpr Mice. Frontiers in Immunology. 12. 651191.
10.3389/fimmu.2021.651191.
6. Banerjee, Nivedita & Wang, Hui & Wang,
Gangduo & Boor, Paul & Khan, M Firoze. (2021). Redox-sensitive Nrf2 and
MAPK signaling pathways contribute to trichloroethene-mediated autoimmune
disease progression. Toxicology. 457. 152804. 10.1016/j.tox.2021.152804.
7. Wang, Gangduo & Wang, Hui & Banerjee, Nivedita &
Khan, M Firoze. (2020). Interplay and roles of oxidative stress, toll-like
receptor 4 and Nrf2 in trichloroethene-mediated autoimmunity. Toxicology and
Applied Pharmacology. 408. 10.1016/j.taap.2020.115258.
8. Banerjee, Nivedita & Wang, Hui & Wang,
Gangduo & Khan, M Firoze. (2020). Enhancing the Nrf2 Antioxidant Signaling
Provides Protection Against Trichloroethene-mediated Inflammation and
Autoimmune Response. Toxicological sciences : an official journal of the
Society of Toxicology. 175. 10.1093/toxsci/kfaa022.
9. Khan, M Firoze & Wang, Hui. (2020).
Environmental Exposures and Autoimmune Diseases: Contribution of Gut
Microbiome. Frontiers in Immunology. 10. 3094. 10.3389/fimmu.2019.03094.
10. Wang, Hui & Wang, Gangduo & Liang,
Yuejin & Du, Xiaotang & Boor, Paul & Sun, Jiaren & Khan, M
Firoze. (2019). Redox regulation of hepatic NLRP3 inflammasome activation and
immune dysregulation in trichloroethene-mediated autoimmunity. Free Radical
Biology and Medicine. 143. 10.1016/j.freeradbiomed.2019.08.014.
11. Wang, Gangduo & Wakamiya, Maki & Wang, Jianling
& Ansari, Ghulam & Khan, M Firoze. (2019). Cytochrome P450
2E1-deficient MRL+/+ mice are less susceptible to trichloroethene-mediated
autoimmunity: Involvement of oxidative stress-responsive signaling pathways.
Free Radical Biology and Medicine. 143. 10.1016/j.freeradbiomed.2019.08.022.
12. Wang, Hui & Wang, Gangduo & Liang,
Yuejin & Du, Xiaotang & Sun, Jiaren & Boor, Paul & Khan, M
Firoze. (2019). Amelioration of trichloroethene‐mediated
autophagy, inflammasome activation, and hepatic immune dysregulation by N‐acetylcysteine.
The FASEB Journal. 33. 10.1096/fasebj.2019.33.1_supplement.506.8.
13. Wang, Hui & Wang, Gangduo & Ansari,
Ghulam & Khan, M Firoze. (2018). Trichloroethene metabolite dichloroacetyl
chloride induces apoptosis and compromises phagocytosis in Kupffer Cells:
Activation of inflammasome and MAPKs. PLOS ONE. 13. e0210200.
10.1371/journal.pone.0210200.
14. Wang, Gangduo & Wang, Jianling &
Ansari, Ghulam & Khan, M Firoze. (2018). Tetrachloroethene‐mediated
autoimmunity: Significance of lipid‐derived
aldehydes. The FASEB Journal. 31. 10.1096/fasebj.31.1_supplement.995.3.
15. Wang, Gangduo & Ma, Huaxian & Wang,
Jianling & Khan, M Firoze. (2018). Contribution of
poly(ADP-ribose)polymerase-1 activation and apoptosis in
trichloroethene-mediated autoimmunity. Toxicology and Applied Pharmacology.
362. 10.1016/j.taap.2018.10.012.
16. Khan, M Firoze & Wang, Gangduo. (2017).
Environmental Agents, Oxidative Stress and Autoimmunity. Current Opinion in
Toxicology. 7. 10.1016/j.cotox.2017.10.012.
17. Wang, Gangduo & Wang, Jianling &
Ansari, Ghulam & Khan, M Firoze. (2017). Autoimmune potential of
perchloroethylene: Role of lipid-derived aldehydes. Toxicology and Applied
Pharmacology. 333. 10.1016/j.taap.2017.08.009.
18. Wang, Gangduo & Wang, Jianling & Khan,
M Firoze. (2017). Altered miRNA expression in aniline-mediated cell cycle
progression in rat spleen. Toxicology Mechanisms and Methods. 27. 1-29.
10.1080/15376516.2017.1324932.
19. Wang, Gangduo & Willis, Rohan &
Gonzalez, Emilio & Petri, Michelle & Khan, M Firoze. (2016).
Significance of Lipid-Derived Reactive Aldehyde-Specific Immune Complexes in
Systemic Lupus Erythematosus. PLOS ONE. 11. 10.1371/journal.pone.0164739.
20. Wang, Gangduo & Wakamiya, Maki & Wang,
Jianling & Ansari, Ghulam & Khan, M Firoze. (2015). INOS null MRL+/+
mice show attenuation of trichloroethene-mediated autoimmunity: Contribution of
reactive nitrogen species and lipid-derived reactive aldehydes. Free radical
biology & medicine. 89. 10.1016/j.freeradbiomed.2015.10.402.
Profile Details
https://www.utmb.edu/pathology/faculty/m-firoze-khan-phd