Dr. Jonathan R. Keller

National Cancer Insititute-NIH, USA

Email: [email protected]

Qualifications

1985 Ph.D., George Washington University, Washington, USA

1978 B.S., University of Maryland, College Park, Maryland, USA

Publications（Selected）

1. Sarkar, T., Singh, S., Gudmundsson, K., et al. (2023). ID2 Promotes Leukemogenesis and Chemoresistance of Acute Myeloid Leukemia By Modulating Cellular Oxidative Metabolism. Blood, 142(1).
2. Singh, S., Sarkar, T., Morris, H., et al. (2023). Id1 Ablation Rescues Clonal Hematopoiesis and Delays Disease Progression in Tet2 Null Mice. Blood, 142(1).
3. Singh, S., Sarkar, T., Morris, H., et al. (2023). ID1 ABLATION RESCUES CLONAL HEMATOPOIESIS AND DELAYS DISEASE PROGRESSION IN TET2 NULL MICE. Experimental Hematology, 124(S), S139.
4. Singh, S., Sarkar, T., Jakubison, B., et al. (2022). Inhibitor of DNA binding proteins revealed as orchestrators of steady state, stress and malignant hematopoiesis. Frontiers in Immunology, 13, 934624.
5. Jakubison, B., Sarkar, T., Gudmundsson, K., et al. (2022). ID2 and HIF-1α collaborate to protect quiescent hematopoietic stem cells from activation, differentiation, and exhaustion. Journal of Clinical Investigation, 132(13), e152599.
6. Mishra, A., Hartford, S., Sahu, S., et al. (2022). BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at replication-induced and meiotic DNA double strand breaks. Nature Communications, 13(1), 1751.
7. Parthibane, V., Lin, J., Acharya, D., et al. (2021). SSSPTA is essential for serine palmitoyltransferase function during development and hematopoiesis. Journal of Biological Chemistry, 296, 100491.
8. He, Y., Ren, J., Xu, X., et al. (2020). Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination. Proceedings of the National Academy of Sciences of the United States of America, 117(33), 20100–20108.
9. Singh, S., Jakubison, B., & Keller, J. (2020). Protection of hematopoietic stem cells from stress-induced exhaustion and aging. Current Opinion in Hematology, 27(4), 225–231.
10. Zheng, M., Zhong, C., Cui, K., et al. (2020). Quantitative Expression of GATA3 Specifies Lineage Fates and Functions of Innate Lymphoid Cells. Journal of Immunology, 204(1).
11. Gadomski, S., Singh, S., Singh, S., et al. (2020). Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration. Cell Reports, 31(4), 107572.
12. Zhong, C., Zheng, M., Cui, K., et al. (2020). Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells. Immunity, 52(1), 83.
13. Parthibane, V., Acharya, D., Srideshikan, S., et al. (2019). Sptlc1 is essential for myeloid differentiation and hematopoietic homeostasis. Blood Advances, 3(22), 3635–3649.
14. Singh, S., Singh, S., Gadomski, S., et al. (2018). Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging. Cell Stem Cell, 23(2), 252.
15. Gudmundsdottir, B., Gudmundsson, K., Klarmann, K., et al. (2018). POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin Expression. Cell Reports, 23(11), 3236–3248.
16. Ali, M., Li, H., Klarmann, K., et al. (2018). Gfi-1 Levels regulate hematopoietic stem cell reconstitution and leukemic cell growth by inducing cell cycle arrest and differentiation. Cancer Medicine, 7(1), 40.
17. Singh, S., Singh, S., Gadomski, S., et al. (2017). Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging. Blood, 130(1).
18. Seaman, S., Zhu, Z., Saha, S., et al. (2017). Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature. Cancer Cell, 31(4), 501.
19. Song, Y., Sullivan, T., Klarmann, K., et al. (2017). RB inactivation in keratin 18 positive thymic epithelial cells promotes non-cell autonomous T cell hyperproliferation in genetically engineered mice. PLOS ONE, 12(2), e0171510.
20. Puverel, S., Kiris, E., Singh, S., et al. (2016). RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells. Oncotarget, 7(51), 85109–85123.

Profile Details
https://ccr.cancer.gov/staff-directory/jonathan-r-keller
https://www.researchgate.net/profile/Jonathan-Keller-6
https://scholar.google.com/citations?user=ex2OzkUAAAAJ&hl=en

WOS ResearcherID: O-6677-2018