The Center on Aging and Associated Diseases

Children's Cancer Hospital

Zewail City of Science and Technology, Egypt

Professor and Director

Department of Anesthesiology

University of California San Diego, USA

Associate Professor

E-mail: [email protected], [email protected]

Qualifications

1997 Ph.D.,Tohoku University, Japan, Magnetic Effects on Free Radical Reactions

1994 M.Sc.,Tohoku University, Japan, Photochemistry

1988 B.Sc., Ain Shams University, Egypt, Chemistry

Publications (Selected)

1. Sirota S B, Bender R G, Dominguez R M V, et al. Global burden of lower respiratory infections and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023[J]. The Lancet Infectious Diseases, 2025.
2. Amer K, Soliman N A, Soror S, et al. Egypt Genome: Towards an African new genomic era[J]. Journal of Advanced Research, 2025, 71: 415-427.
3. Abdelhamid A H, Omar A M A, Yahia N H, et al. In-situ growing of MIL88A (Fe)@ active faceted Cu2O core-shell heterostructure for super photocatalytic performance and catalytic reduction of toxic nitrophenol compounds[J]. Journal of Alloys and Compounds, 2025, 1010: 177701.
4. Helmy S W A, Abdel-Aziz A K, Dokla E M E, et al. Novel sulfonamide-indolinone hybrids targeting mitochondrial respiration of breast cancer cells[J]. European Journal of Medicinal Chemistry, 2024, 268: 116255.
5. Yasseen B A, Elkhodiry A A, El-sayed H, et al. Evidence associating neutrophilia, lung damage, hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality in critically ill COVID-19 patients[J]. bioRxiv, 2023: 2023.09. 17.558185.
6. Yasseen B A, Elkhodiry A A, El-Messiery R M, et al. Platelets’ morphology, metabolic profile, exocytosis, and heterotypic aggregation with leukocytes in relation to severity and mortality of COVID-19-patients[J]. Frontiers in Immunology, 2022, 13: 1022401.
7. Chang S, Tat J, China S P, et al. Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice[J]. PNAS nexus, 2022, 1(4): pgac191.
8. Badawy M A, Yasseen B A, El-Messiery R M, et al. Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality[J]. Elife, 2021, 10: e69417.
9. Abdel-Rahman E A, Hosseiny S, Aaliya A, et al. Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria[J]. Journal of advanced research, 2021, 31: 35-47.
10. Abdel-Rahman E A, Zaky E A, Aboulsaoud M, et al. Autism spectrum disorder (ASD)-associated mitochondrial deficits are revealed in children’s platelets but unimproved by hyperbaric oxygen therapy[J]. Free Radical Research, 2021, 55(1): 26-40.
11. Emad A M, Ali S F, Abdel‐Rahman E A, et al. Anti‐inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen‐induced acute liver toxicity[J]. Journal of Food Biochemistry, 2020, 44(10): e13399.
12. Ahmed G A R, Khalil S K H, Abbas L, et al. ATR-IR and EPR spectroscopy for detecting the alterations in cortical synaptosomes induced by aluminium stress[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 228: 117535.
13. Reda A, Refaat A, Abd-Rabou A A, et al. Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells[J]. Scientific Reports, 2019, 9(1): 13748.
14. Dugan L L, Behrens M M. Methods for ameliorating and preventing central nervous system inflammation: U.S. Patent 9,944,583[P]. 2018-4-17.
15. Riederer P, Korczyn A D, Ali S S, et al. The diabetic brain and cognition[J]. Journal of neural transmission, 2017, 124(11): 1431-1454.
16. Thomas J L, Pham H, Li Y, et al. Hypoxia-inducible factor-1α activation improves renal oxygenation and mitochondrial function in early chronic kidney disease[J]. American Journal of Physiology-Renal Physiology, 2017, 313(2): F282-F290.
17. Khalifa A R M, Abdel‐Rahman E A, Mahmoud A M, et al. Sex‐specific differences in mitochondria biogenesis, morphology, respiratory function, and ROS homeostasis in young mouse heart and brain[J]. Physiological reports, 2017, 5(6): e13125.
18. El Shaer M, Zaki A, Reda A M, et al. Effect of plasma activated mist on breast cancer cells[J]. IEEE Transactions on Radiation and Plasma Medical Sciences, 2017, 2(2): 103-108.
19. A. Abdel‐Rahman E, Mahmoud A M, Khalifa A M, et al. Physiological and pathophysiological reactive oxygen species as probed by EPR spectroscopy: The underutilized research window on muscle ageing[J]. The Journal of physiology, 2016, 594(16): 4591-4613.
20. Jiang J, Chan A, Ali S, et al. Hydrogen sulfide—mechanisms of toxicity and development of an antidote[J]. Scientific reports, 2016, 6(1): 20831.
21. Abdel-Rahman E A, Mahmoud A M, Aaliya A, et al. Resolving Contributions of Oxygen‐Consuming and ROS‐Generating Enzymes at the Synapse[J]. Oxidative Medicine and Cellular Longevity, 2016, 2016(1): 1089364.
22. Zúniga-Hertz J P, Rebelato E, Kassan A, et al. Distinct pathways of cholesterol biosynthesis impact on insulin secretion[J]. J Endocrinol, 2015, 224(1): 75-84.

Profile Details

https://www.zewailcity.edu.eg/main/post_details.php?lang=en&alias=Zewail_City_Launches_the_Center_for_Aging_and_Associated_Diseases

https://orcid.org/0000-0002-0339-6106

https://scholar.google.com/citations?user=IsGmTY4AAAAJ&hl=en

WoS Researcher ID: R-3018-2019