Biography

Prof. Tiziano Tuccinardi

Department of Pharmacy

University of Pisa, Italy

Associate Professor


Email: [email protected]


Qualifications

2015 Associate Professor, Department of Pharmacy, University of Pisa

2014 Adjunct Assistant Professor, Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, USA

2009 Assistant Professor, Department of Pharmacy, University of Pisa, Italy

2006 Ph.D., Computational Chemistry, University of Pisa, Italy

2002 MD, Medicinal Chemistry, University of Pisa, Italy


Publications (selected)

  1. Poli, Giulio & Macchia, Marco & Tuccinardi, Tiziano. (2025). Structure-Based Analysis of Missense Mutations Impacting the Catalytic and Substrate Binding Sites of hRPE65. Journal of Molecular Graphics and Modelling. 136. 108963. 10.1016/j.jmgm.2025.108963. 
  2. Piazza, Lisa & Srinivasan, Sanjana & Tuccinardi, Tiziano & Bajorath, Jürgen. (2025). Transforming molecular cores, substituents, and combinations into structurally diverse compounds using chemical language models. European Journal of Medicinal Chemistry. 291. 117615. 10.1016/j.ejmech.2025.117615. 
  3. Cazzaniga, Giulia & Mori, Matteo & Griego, Anna & Scarpa, Edoardo & Moschetti, Giorgia & Muzzioli, Stefano & Stelitano, Giovanni & Chiarelli, Laurent & Cocorullo, Mario & Casali, Emanuele & Porta, Alessio & Zanoni, Giuseppe & Tresoldi, Andrea & Pini, Elena & Batalha, Íris & Battaglia, Giuseppe & Tuccinardi, Tiziano & Rizzello, Loris & Villa, Stefania & Meneghetti, Fiorella. (2025). Nanoenabling MbtI Inhibitors for Next-Generation Tuberculosis Therapy. Journal of medicinal chemistry. 68. 10.1021/acs.jmedchem.4c02386. 
  4. Bononi, Giulia & Granchi, Carlotta & Tuccinardi, Tiziano & Minutolo, Filippo. (2025). Identification of a Possible Endocannabinoid-Mediated Mechanism of Action of Cetylated Fatty Acids. Biomolecules. 15. 363. 10.3390/biom15030363. 
  5. Di Stefano, Miriana & Piazza, Lisa & Poles, Clarissa & Galati, Salvatore & Granchi, Carlotta & Giordano, Antonio & Campisi, Luca & Macchia, Marco & Poli, Giulio & Tuccinardi, Tiziano. (2025). KinasePred: A Computational Tool for Small-Molecule Kinase Target Prediction. International Journal of Molecular Sciences. 26. 2157. 10.3390/ijms26052157. 
  6. Nencetti, Susanna & Cuffaro, Doretta & Ciccone, Lidia & Nocentini, Alessio & Di Stefano, Miriana & Poli, Giulio & Macchia, Marco & Tuccinardi, Tiziano & Nuti, Elisa & Supuran, Claudiu & Rossello, Armando & Orlandini, Elisabetta. (2025). A series of benzensulfonamide derivatives as new potent carbonic anhydrase IX and XII inhibitors. Future medicinal chemistry. 17. 1-15. 10.1080/17568919.2025.2453420. 
  7. Di Stefano, Miriana & Galati, Salvatore & Lonzi, Chiara & Granchi, Carlotta & Poli, Giulio & Tuccinardi, Tiziano & Macchia, Marco. (2024). WaSPred: A reliable AI-based water solubility predictor for small molecules. International Journal of Pharmaceutics. 666. 124817. 10.1016/j.ijpharm.2024.124817. 
  8. Palazzolo, Stefano & Saorin, Gloria & Corona, Giuseppe & Granchi, Carlotta & Tuccinardi, Tiziano & Kamensek, Urska & Kranjc, Simona & Cemazar, Maja & Canzonieri, Vincenzo & Rizzolio, Flavio. (2024). A carrier free delivery system of a MAGL inhibitor is effective on ovarian cancer. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 203. 114397. 10.1016/j.ejpb.2024.114397. 
  9. Di Stefano, M., Galati, S., Piazza, L., Gado, F., Granchi, C., Macchia, M., … Poli, G. (2024). Watermelon: setup and validation of an in silico fragment-based approach. Journal of Enzyme Inhibition and Medicinal Chemistry, 39(1). https://doi.org/10.1080/14756366.2024.2356179
  10. Mattioli, S., Fratini, F., Cacchiarelli, C., Martinis, V., Tuccinardi, T., Paci, G., … Mancini, S. (2024). Chemical composition, fatty acid profile, antioxidant content, and microbiological loads of lesser mealworm, mealworm, and superworm larvae. Italian Journal of Animal Science, 23(1), 125–137. https://doi.org/10.1080/1828051X.2023.2293856
  11. Bononi, G., Lonzi, C., Tuccinardi, T., Minutolo, F., & Granchi, C. (2024). The Benzoylpiperidine Fragment as a Privileged Structure in Medicinal Chemistry: A Comprehensive Review. Molecules, 29(9), 1930. https://doi.org/10.3390/molecules29091930
  12. Åbacka, H., Masoni, S., Poli, G. et al. SMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia. Sci Rep 14, 9104 (2024). https://doi.org/10.1038/s41598-024-58689-1
  13. Poli, G., Demontis, G. C., Sodi, A., Saba, A., Rizzo, S., Macchia, M., & Tuccinardi, T. (2023). An in silico toolbox for the prediction of the potential pathogenic effects of missense mutations in the dimeric region of hRPE65. Journal of Enzyme Inhibition and Medicinal Chemistry, 38(1). https://doi.org/10.1080/14756366.2022.2162047
  14. Galati, S., Di Stefano, M., Bertini, S., Granchi, C., Giordano, A., Gado, F., Macchia, M., Tuccinardi, T., & Poli, G. (2023). Identification of New GSK3β Inhibitors through a Consensus Machine Learning-Based Virtual Screening. International Journal of Molecular Sciences, 24(24), 17233. https://doi.org/10.3390/ijms242417233
  15. Berrino, E., Carradori, S., Carta, F., Melfi, F., Gallorini, M., Poli, G., Tuccinardi, T., Fernández-Bolaños, J. G., López, Ó., Petzer, J. P., Petzer, A., Guglielmi, P., Secci, D., & Supuran, C. T. (2023). A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration. Antioxidants, 12(12), 2044. https://doi.org/10.3390/antiox12122044
  16. Mancini, S., Fratini, F., Provera, I., Dovicchi, J., Tuccinardi, T., Minieri, S., … Paci, G. (2022). Growth performances, chemical composition, and microbiological loads of mealworm reared with brewery spent grains and bread leftovers. Italian Journal of Animal Science, 21(1), 1419–1429. https://doi.org/10.1080/1828051X.2022.2120422
  17. Poli, G., Barravecchia, I., Demontis, G. C., Sodi, A., Saba, A., Rizzo, S., … Tuccinardi, T. (2022). Predicting potentially pathogenic effects of hRPE65 missense mutations: a computational strategy based on molecular dynamics simulations. Journal of Enzyme Inhibition and Medicinal Chemistry, 37(1), 1765–1772. https://doi.org/10.1080/14756366.2022.2090547
  18. Poli, G., Di Stefano, M., Estevez, J. A., Minutolo, F., Granchi, C., Giordano, A., … Rizzolio, F. (2021). New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy. Journal of Enzyme Inhibition and Medicinal Chemistry, 37(1), 145–150. https://doi.org/10.1080/14756366.2021.1979970
  19. Carradori, S., Fantacuzzi, M., Ammazzalorso, A., Angeli, A., De Filippis, B., Galati, S., Petzer, A., Petzer, J. P., Poli, G., Tuccinardi, T., Agamennone, M., & Supuran, C. T. (2022). Resveratrol Analogues as Dual Inhibitors of Monoamine Oxidase B and Carbonic Anhydrase VII: A New Multi-Target Combination for Neurodegenerative Diseases? Molecules, 27(22), 7816. https://doi.org/10.3390/molecules27227816
  20. Bononi, G., Citi, V., Lapillo, M., Martelli, A., Poli, G., Tuccinardi, T., Granchi, C., Testai, L., Calderone, V., & Minutolo, F. (2022). Sirtuin 1-Activating Compounds: Discovery of a Class of Thiazole-Based Derivatives. Molecules, 27(19), 6535. https://doi.org/10.3390/molecules27196535

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