Prof. Yovani Marrero Ponce

College of Health Sciences

Universidad San Francisco de Quito, Ecuador

Email: [email protected]

Qualifications

2005 Ph.D., Chemical Sciences, Havana University, Cuba

2002 M.Sc., Biochemistry, Medical University, Cuba

2001 B.Sc., Pharmaceutical Sciences, Central University of Las Villas, Cuba

Publications (selected)

1. Quiroz-Perozo, Yasmir & Mora, Marylu & Vivas, Alejandro & Gonzalez-Paz, Lenin & Alvarado, Ysaías & Rodríguez Lugo, Patricia & Cardozo, Arlene & Bravo, Yanauri & Vera, Joan & Martinez, Felix & Toro-Mendoza, Jhoan & Marrero-Ponce, Yovani & Loroño-González, Marcos & Paz, José. (2025). Conformational Changes in Nf-κB Induced by Interaction with Sildenafil: A Biophysical-Computational Approach with Implications for Inflammatory Diseases. 10.20944/preprints202503.1959.v1. 
2. Sierra-Hernandez, Olimpo & Saurith-Coronell, Oscar & Rodríguez-Macías, Juan & Marquez, Edgar & Mora, José & Paz, José & Flores-Sumoza, Maryury & Mendoza-Mendoza, Adel & Flores-Morales, Virginia & Marrero-Ponce, Yovani & Barigye, Stephen & Martinez, Felix. (2025). In Silico Identification of Potential Clovibactin-like Antibiotics Binding to Unique Cell Wall Precursors in Diverse Gram-Positive Bacterial Strains. International Journal of Molecular Sciences. 26. 10.3390/ijms26041724. 
3. García, María & Cuesta Hoyos, Sebastian & Mora, Jose & Paz, Jose & Marrero-Ponce, Yovani & Alexis, Frank & Marquez, Edgar. (2025). Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease. Scientific Reports. 15. 10.1038/s41598-025-86926-8. 
4. Barroso, Ricardo & Aguero-Chapin, Guillermin & Sousa, Rita & Marrero-Ponce, Yovani & Antunes, Agostinho. (2025). Unlocking Antimicrobial Peptides: In Silico Proteolysis and Artificial Intelligence-Driven Discovery from Cnidarian Omics. Molecules. 30. 550. 10.3390/molecules30030550. 
5. Alvarado, Ysaías & Gonzalez-Paz, Lenin & Paz, José & Loroño-González, Marcos & Contreras, Julio & Lossada, Carla & Vivas, Alejandro & Marrero-Ponce, Yovani & Martinez, Felix & Rodríguez Lugo, Patricia & Balladores, Yanpiero & Vera, Joan. (2024). Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study. Biology. 13. 1065. 10.3390/biology13121065. 
6. Molina, Luis & Pichazaca, María & Padilla, José & Calle, María & Pinos, Karla & Cardozo, Arlene & Lossada, Carla & Marrero-Ponce, Yovani & Martinez, Felix & Alvarado, Ysaías & Pérez, Aleivi & Gonzalez-Paz, Lenin. (2024). Macromolecular interaction mechanism of the bacteriocin EntDD14 with the receptor binding domain (RBD) for the inhibition of SARS-CoV-2 and the JN.1 variant: Biomedical study based on elastic networks, stochastic Markov models, and macromolecular volumetric analysis. Biophysical Chemistry. 318. 107388. 10.1016/j.bpc.2024.107388. 
7. Bernal, Anthony & Marquez, Edgar & Flores-Sumoza, Máryury & Cuesta Hoyos, Sebastian & Mora, José & Paz, José & Mendoza-Mendoza, Adel & Rodríguez-Macías, Juan & Salazar, Franklin & Insuasty, Daniel & Marrero-Ponce, Yovani & Aguero-Chapin, Guillermin & Flores-Morales, Virginia & Carrascal-Hernández, Domingo. (2024). Molecular Modeling of Vasodilatory Activity: Unveiling Novel Candidates Through Density Functional Theory, QSAR, and Molecular Dynamics. International Journal of Molecular Sciences. 25. 12649. 10.3390/ijms252312649. 
8. Contreras-Torres, Ernesto & Marrero-Ponce, Yovani. (2024). MD-LAIs Software: Computing Whole-Sequence and Amino Acid-Level "Embeddings" for Peptides and Proteins. Journal of chemical information and modeling. 64. 10.1021/acs.jcim.3c01189. 
9. Aguero-Chapin, Guillermin & Domínguez Pérez, Dany & Marrero-Ponce, Yovani & Castillo-Mendieta, Kevin & Antunes, Agostinho. (2024). Unveiling Encrypted Antimicrobial Peptides from Cephalopods’ Salivary Glands: A Proteolysis-Driven Virtual Approach. ACS Omega. 9. 10.1021/acsomega.4c01959. 
10. Castillo-Mendieta, Kevin & Aguero-Chapin, Guillermin & Marquez, Edgar & Perez Castillo, Yunierkis & Barigye, Stephen & Santiago Vispo, Nelson & García-Jacas, César & Marrero-Ponce, Yovani. (2024). Peptide hemolytic activity analysis using visual data mining of similarity-based complex networks. npj Systems Biology and Applications. 10. 1-18. 10.1038/s41540-024-00429-2. 
11. Cola-Pilicita, Cristhian & Martínez-Mejía, Mateo & Alba, Eduardo & Marrero-Ponce, Yovani & Pérez, Noel. (2024). Towards a Mixed Learning Strategy for Discovering New Gene Signatures in Breast Cancer Prognosis. 947-951. 10.1109/ARGENCON62399.2024.10735947. 
12. Castillo-Mendieta, Kevin & Aguero-Chapin, Guillermin & Mora, Jose & Pérez, Noel & Contreras-Torres, Ernesto & Valdes, J. & Martinez, Felix & Marrero-Ponce, Yovani. (2024). Unraveling the Hemolytic Toxicity Tapestry of Peptides using Chemical Space Complex Networks. Toxicological sciences : an official journal of the Society of Toxicology. 202. 10.1093/toxsci/kfae115. 
13. García, Daniela & Marrero-Ponce, Yovani & Aguero-Chapin, Guillermin & Ferri, Francesc & Antunes, Agostinho & Martinez, Felix & Rodríguez, Hortensia. (2024). Innovative Alignment-Based Method for Antiviral Peptide Prediction. Antibiotics. 13. 768. 10.3390/antibiotics13080768. 
14. Castillo-Mendieta, Kevin & Marrero-Ponce, Yovani & Aguero-Chapin, Guillermin & Marquez, Edgar & Perez Castillo, Yunierkis & Barigye, Stephen & Pérez-Giménez, Facundo. (2024). Multiquery Similarity Searching Models: An Alternative Approach for Predicting Hemolytic Activity from Peptide Sequence. Chemical research in toxicology. 37. 10.1021/acs.chemrestox.3c00408. 
15. cañizares-carmenate, Yudith & Perera-Sardiña, Yunier & Marrero-Ponce, Yovani & Diaz-Amador, Roberto & Torrens, F & Castillo-Garit, Juan. (2024). Ligand and structure-based discovery of phosphorus-containing compounds as potential metalloproteinase inhibitors. SAR and QSAR in environmental research. 35. 1-22. 10.1080/1062936X.2024.2314103. 
16. Mora, Jose & Marquez, Edgar & Pérez, Noel & Contreras-Torres, Ernesto & Perez Castillo, Yunierkis & Aguero-Chapin, Guillermin & Martinez, Felix & Marrero-Ponce, Yovani & Barigye, Stephen. (2024). Rethinking the applicability domain analysis in QSAR models. Journal of Computer-Aided Molecular Design. 38. 9. 10.1007/s10822-024-00550-8. 
17. Vivas-Reyes, R., Martínez-Santiago, O. & Marrero-Ponce, Y. Graph derivative indices interpretation from the quantum mechanics perspective. J Math Chem 61, 1739–1757 (2023). https://doi.org/10.1007/s10910-023-01489-1
18. Agüero-Chapin, G., Antunes, A., Mora, J. R., Pérez, N., Contreras-Torres, E., Valdes-Martini, J. R., Martinez-Rios, F., Zambrano, C. H., & Marrero-Ponce, Y. (2023). Complex Networks Analyses of Antibiofilm Peptides: An Emerging Tool for Next-Generation Antimicrobials’ Discovery. Antibiotics, 12(4), 747. https://doi.org/10.3390/antibiotics12040747
19. Cabrera, N., Cuesta, S.A., Mora, J.R. et al. Searching glycolate oxidase inhibitors based on QSAR, molecular docking, and molecular dynamic simulation approaches. Sci Rep 12, 19969 (2022). https://doi.org/10.1038/s41598-022-24196-4
20. Agüero-Chapin, G., Galpert-Cañizares, D., Domínguez-Pérez, D., Marrero-Ponce, Y., Pérez-Machado, G., Teijeira, M., & Antunes, A. (2022). Emerging Computational Approaches for Antimicrobial Peptide Discovery. Antibiotics, 11(7), 936. https://doi.org/10.3390/antibiotics11070936

Profile Details

https://www.usfq.edu.ec/en/profiles/yovani-marrero-ponce