Prof. Lei Fu
Academy of Pharmacy
Xi'an Jiaotong-Liverpool University, China

Email: [email protected]

Qualifications
1993-1997 Ph.D., Department of Chemistry, Stanford University, USA
1984-1987 M.Sc., Department of Nuclear Science, Fudan University, China
1980-1984 B.Sc., Department of Chemistry, Fudan University, China

Publications (selected)

1. Hu, Yixin & Zhang, Yang & Guo, Jie & Chen, Shihao & Jin, Jie & Li, Pengyu & Pan, Yuchen & Lei, Shuwen & Li, Jiaqi & Wu, Suheng & Bu, Buzhou & Fu, Lei. (2024). Synthesis and anti-proliferative effect of novel 4-Aryl-1, 3-Thiazole-TPP conjugates via mitochondrial uncoupling process. Bioorganic chemistry. 150. 107588. 10.1016/j.bioorg.2024.107588. 
2. Sun, Ran & Hu, Yangfan & Liu, Xiangwen & Lin, Yingjun & Lv, Dan & Li, Wei & Fu, Lei & Jiang, Faqin. (2024). Discovery, optimization and biological activity evaluation of genipin derivatives as potential KRAS G12D inhibitors. Bioorganic chemistry. 148. 107460. 10.1016/j.bioorg.2024.107460. 
3. Lei, Shuwen & Qiao, Yixue & Sultana, Zakia & Fu, Lei & Smith, Roger. (2023). Development of novel AOX1 inhibitors to prevent or reverse placental oxidative damage. Placenta. 140. e56-e57. 10.1016/j.placenta.2023.07.186. 
4. Zhang, Yang & Wang, Juntao & Lei, Shuwen & Hu, Yixin & Fu, Lei. (2022). Utilization of mitochondrial-targeted small molecules in protecting stored platelets against storage lesions. European Journal of Medicinal Chemistry Reports. 6. 100070. 10.1016/j.ejmcr.2022.100070. 
5. Chen, Bojie & Lei, Shuwen & Yin, Xinlu & Fei, Mengjia & Hu, Yixin & Shi, Yuan & Xu, Yanan & Fu, Lei. (2022). Mitochondrial Respiration Inhibition Suppresses Papillary Thyroid Carcinoma Via PI3K/Akt/FoxO1/Cyclin D1 Pathway. Frontiers in Oncology. 12. 900444. 10.3389/fonc.2022.900444. 
6. Gu, Jinxin & Chen, Lixue & Sun, Ran & Wang, Jie-Li & Wang, Juntao & Lin, Yingjun & Lei, Shuwen & Zhang, Yang & Lv, Dan & Jiang, Faqin & Deng, Yuru & Collman, James & Fu, Lei. (2022). Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in Mice. Frontiers in Molecular Biosciences. 9. 10.3389/fmolb.2022.815320. 
7. Wang, Juntao & Lu, Dan & Sun, Ran & Lei, Shuwen & Luo, Shuhua & Dang, Xin & Zhang, Yang & Yuan, Chang & Zhang, Yong & Wu, Jinhong & Yang, Guangyu & Fu, Lei & Jiang, Faqin. (2022). One-Pot Enzymatic Synthesis and Biological Evaluation of Ganglioside GM3 Derivatives as Potential Cancer Immunotherapeutics. Journal of Medicinal Chemistry. 65. 10.1021/acs.jmedchem.1c01301. 
8. Ip, Fanny & Fu, Guangmiao & Yang, Fengzhi & Fangyuan, Kang & Sun, Peiran & Ling, Choi & Cheung, Kit & Xie, Fangzhou & Hu, Yueqing & Fu, Lei & Ip, Nancy. (2021). A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice. European Journal of Medicinal Chemistry. 226. 113827. 10.1016/j.ejmech.2021.113827. 
9. Lei, Shuwen & Hu, Yang & Yuan, Chang & Sun, Ran & Wang, Juntao & Zhang, Yong & Zhang, Yang & Lu, Dan & Fu, Lei & Jiang, Faqin. (2021). Discovery of Sortase A covalent inhibitors with benzofuranene cyanide structures as potential antibacterial agents against Staphylococcus aureus. European Journal of Medicinal Chemistry. 229. 114032. 10.1016/j.ejmech.2021.114032. 
10. Zhang, Zixue & Zhang, Qingwei & Zhang, Hao & Jiao, Minru & Guo, Zheng & Peng, Xinyan & Fu, Lei & Li, Jianqi. (2021). Discovery of quinazolinyl-containing benzamides derivatives as novel HDAC1 inhibitors with in vitro and in vivo antitumor activities. Bioorganic Chemistry. 117. 105407. 10.1016/j.bioorg.2021.105407. 
11. Zhang, Dongdong & Hu, Yixin & Hao, Zhiqiang & Zhang, Yang & Luo, Shuhua & Dang, Xin & Sun, Ran & Duan, Shixin & Lv, Dan & Jiang, Faqin & Fu, Lei. (2021). Design, Synthesis and Antitumor Activities of Thiazole-containing Mitochondrial Targeting Agents. Bioorganic Chemistry. 115. 105271. 10.1016/j.bioorg.2021.105271. 
12. Luo, Shuhua & Dang, Xin & Wang, Juntao & Yuan, Chang & Hu, Yixin & Lei, Shuwen & Zhang, Yang & Lua, Dan & Jiang, Faqin & Fu, Lei. (2021). Biological Evaluation of Mitochondria Targeting Small Molecules as Potent Anticancer Drugs. Bioorganic Chemistry. 114. 105055. 10.1016/j.bioorg.2021.105055. 
13. Choudhury, Sharmin & Gu, Jinxin & Yixin, Hu & Wang, Juntao & Lei, Shuwen & Tavallaie, Mojdeh & Lam, Celine & Lu, Dan & Jiang, Faqin & Fu, Lei. (2021). Synthesis, biological evaluation and molecular modeling of Benzofuran piperidine derivatives as Aβ antiaggregant. European Journal of Medicinal Chemistry. 222. 113541. 10.1016/j.ejmech.2021.113541. 
14. Dang, Xin & Lei, Shuwen & Luo, Shuhua & Hu, Yixin & Wang, Juntao & Zhang, Dongdong & Lu, Dan & Jiang, Faqin & Fu, Lei. (2021). Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells. Bioorganic Chemistry. 114. 105015. 10.1016/j.bioorg.2021.105015. 
15. Deng, Xinxian & Cai, Qingqing & Fu, Lei & Lei, Shuwen. (2020). Structural optimization of pyrazolo[1,5-a]pyrimidine derivatives as potent and highly selective DPP-4 inhibitors. European Journal of Medicinal Chemistry. 208. 10.1016/j.ejmech.2020.112850. 
16. Lei, Shuwen & Zhang, Dongdong & Qi, Yunyue & Choudhury, Sharmin & Sun, Ran & Wang, Juntao & Du, Yi & Fu, Lei & Jiang, Faqin. (2020). Synthesis and Biological Evaluation of Geniposide derivatives as potent and selective PTPlB inhibitors. European Journal of Medicinal Chemistry. 205. 112508. 10.1016/j.ejmech.2020.112508. 
17. Tavallaie, Mojdeh & Voshtani, Ramouna & Deng, Xinxian & Qiao, Yixue & Jiang, Faqin & Collman, James & Fu, Lei. (2020). Moderation of mitochondrial respiration mitigates metabolic syndrome of aging. Proceedings of the National Academy of Sciences. 117. 9840-9850. 10.1073/pnas.1917948117. 
18. Deng, Xinxian & Tavallaie, Mojdeh & Sun, Ran & Wang, Juntao & Cai, Qingqing & Shen, Jian & Lei, Shuwen & Fu, Lei & Jiang, Faqin. (2020). Drug Discovery Approaches Targeting the Incretin Pathway. Bioorganic Chemistry. 99. 103810. 10.1016/j.bioorg.2020.103810. 
19. Wang, Di & Liu, Yafei & Zhu, Wei & Shen, Hong & Liu, Haixia & Fu, Lei. (2020). Efficient Synthesis of Substituted Morpholine Derivatives via an Indium (III)-Catalyzed Reductive Etherification Reaction. Chemistry Letters. 49. 10.1246/cl.200142. 
20. Qiao, Yixue & Dsouza, Charlotte & Matthews, Abigail & Jin, Yan & He, Wan & Bao, Jian & Jiang, Faqin & Chandna, Ritu & Ge, Ruowen & Fu, Lei. (2020). Discovery of small molecules targeting GRP78 for antiangiogenic and anticancer therapy. European Journal of Medicinal Chemistry. 193. 112228. 10.1016/j.ejmech.2020.112228. 

Profile Details

https://scholar.xjtlu.edu.cn/en/persons/LeiFu