Prof. Weizhen Zhang

Peking University, China

University of Michigan,USA

E-mail: [email protected]; [email protected]

Qualifications

1991-1994 Doctor in Medicine, Peking University Health Science Center, Beijing, China

1987-1990 Master in Medicine, Capital Institute of Medicine, Beijing, China

1981-1987 Bachelor in Medicine, Sun Yat-sen University of Medical Sciences, Guangzhou, China

Publications (Selected)

1. Zhu, Z., Yang, Y., Sun, L., Zhang, Y., Han, X., Luo, C., ... & Zhang, W. (2025). GPR180 reduces adiposity by inhibiting lipogenesis and fatty acid uptake in adipocytes. American Journal of Physiology-Endocrinology and Metabolism, 328(3), E410-E419.
2. Liang, Y., Luo, C., Sun, L., Feng, T., Yin, W., Zhang, Y., ... & Yin, Y. (2024). Reduction of specific enterocytes from loss of intestinal LGR4 improves lipid metabolism in mice. Nature Communications, 15(1), 4393.
3. Bi, Y., Zhang, L., Song, Y., Sun, L., Mulholland, M. W., Yin, Y., & Zhang, W. (2024). Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway. Gastroenterología y Hepatología, 47(4), 352-365.
4. Chen, H., Sun, L., Feng, L., Han, X., Zhang, Y., Zhai, W., ... & Yin, Y. (2024). Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue. Elife, 12, RP91060.
5. Gao, Y., Zhai, W., Sun, L., Du, X., Wang, X., Mulholland, M. W., ... & Zhang, W. (2024). Hepatic LGR4 aggravates cholestasis-induced liver injury in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 326(4), G460-G472.
6. Feng, T., Liang, Y., Sun, L., Feng, L., Min, J., Mulholland, M. W., ... & Zhang, W. (2023). Regulation of hepatic lipid metabolism by intestine epithelium-derived exosomes. Life Metabolism, 2(6), load044.
7. Bi, Y., Zhang, L., Song, Y., Sun, L., Mulholland, M. W., Yin, Y., & Zhang, W. (2024). Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway. Gastroenterología y Hepatología, 47(4), 352-365.
8. Zhang, Y., Zhu, Z., Sun, L., Yin, W., Liang, Y., Chen, H., ... & Zhang, W. (2023). Hepatic G protein-coupled receptor 180 deficiency ameliorates high fat diet-induced lipid accumulation via the Gi-PKA-SREBP pathway. Nutrients, 15(8), 1838.
9. Yin, W., Sun, L., Liang, Y., Luo, C., Feng, T., Zhang, Y., ... & Yin, Y. (2023). Maternal intermittent fasting deteriorates offspring metabolism via suppression of hepatic mTORC1 signaling. The FASEB Journal, 37(4), e22831.
10. Liang, Y., Yin, W., Luo, C., Sun, L., Feng, T., Zhang, Y., ... & Zhang, W. (2023). Maternal intermittent fasting in mice disrupts the intestinal barrier leading to metabolic disorder in adult offspring. Communications Biology, 6(1), 30.
11. Liang, Y., Yu, R., He, R., Sun, L., Luo, C., Feng, L., ... & Zhang, W. (2022). Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass. Frontiers in Endocrinology, 13, 891379.
12. Liu, L., Huwatibieke, B., Lu, X., Li, D., Dong, H., Han, J., ... & Li, Y. (2022). TCDD-inducible poly (ADP-ribose) polymerase promotes adipogenesis of both brown and white preadipocytes. Journal of Translational Internal Medicine, 10(3), 246-254.
13. Huwatibieke, B., Yin, W., Liu, L., Jin, Y., Xiang, X., Han, J., ... & Li, Y. (2021). Mammalian target of rapamycin signaling pathway regulates mitochondrial quality control of brown adipocytes in mice. Frontiers in Physiology, 12, 638352.
14. Yuan, F., Zhang, Q., Dong, H., Xiang, X., Zhang, W., Zhang, Y., & Li, Y. (2021). Effects of des-acyl ghrelin on insulin sensitivity and macrophage polarization in adipose tissue. Journal of Translational Internal Medicine, 9(2), 84-97.
15. Yin, W., Liang, Y., Sun, L., Yin, Y., & Zhang, W. (2021). Maternal intermittent fasting before mating alters hepatic DNA methylation in offspring. Epigenomics, 13(5), 341-356.
16. Yin, Y., Wang, Q., Qi, M., Zhang, C., Li, Z., & Zhang, W. (2021). Ghrelin ameliorates nonalcoholic steatohepatitis induced by chronic low‐grade inflammation via blockade of Kupffer cell M1 polarization. Journal of cellular physiology, 236(7), 5121-5133.
17. Mao, Z., Feng, M., Li, Z., Zhou, M., Xu, L., Pan, K., ... & Zhang, W. (2021). ETV5 regulates hepatic fatty acid metabolism through PPAR signaling pathway. Diabetes, 70(1), 214-226.

Profile Details

https://orcid.org/0000-0001-8791-2798

https://physiology.bjmu.edu.cn/HomePage/Staffs/Professors/0150aa46e48844b98afd56625060a2bc.htm

https://www.researchgate.net/profile/Wei-Zhen-Zhang-2

https://loop.frontiersin.org/people/1335963/overview