Biography

Prof. Artur Manuel Soares Silva

Universidade de Aveiro, Portugal


Email: [email protected]


Qualifications

2001 - present Full Professor, Department of Chemistry, University of Aveiro

2001 - 2006 Head of the Chemistry Department, University of Aveiro


Publications (Selected)

  1. “Structure-function relationships of pectic polysaccharides from broccoli by-products with in vitro B lymphocyte stimulatory activity”, Sónia S. Ferreira, Alexandra Correia, Artur M.S. Silva, Dulcineia Ferreira Wessel, Susana M. Cardoso, Manuel Vilanova, Manuel A. Coimbra, Carbohydrate Polymers, 2023, 303, 120432. https://doi.org/10.1016/j.carbpol.2022.120432.
  2. “Synthesis of Bis(3-indolyl)methanes Mediated by Potassium tert-Butoxide”, A. Sofia Santos, Rita D. Ferro, Nuno Viduedo, Luísa B. Maia, Artur M. S. Silva, M. Manuel B. Marques, ChemistryOpen., 2023, 12, e202200265. doi.org/10.1002/open.202200265.
  3. “Curcumin-based molecular probes for fluorescence imaging of fungi”, Joana R. M. Ferreira, Mariana Alves, Bárbara Sousa, Sandra I. Vieira, Artur M. S. Silva, a Samuel Guieu, Ângela Cunha, Raquel Nunes da Silva, Org. Biomol. Chem., 2023, 21, 1531–1536. doi: 10.1039/d2ob01872a.
  4. “Inula viscosa (L.) Aiton Ethanolic Extract Inhibits the Growth of Human AGS and A549 Cancer Cell Lines”, Habiba Rechek, Ammar Haouat, Kaouther Hamaidia, Diana C. G. A. Pinto, Tarek Boudiar, Monica S. G. A. Valega, David M. Pereira, Renato B. Pereira, Artur M. S. Silva, Chem. Biodiversity, 2023, 20, e202200890. doi.org/10.1002/cbdv.202200890.
  5. “Microwave-assisted synthesis of 4,6-disubstituted isoindoline-1,3-diones by Diels-Alder reactions”, Fatiha Nouali, Joana L.C. Sousa, Hélio M.T. Albuquerque, Ricardo F. Mendes, Filipe A. Almeida Paz, Liza Saher, Zahira Kibou, Nouredine Choukchou-Braham, Oualid Talhi, Artur M.S. Silva, J. Mol. Struct., 2023, 1275, 134608. https://doi.org/10.1016/j.molstruc.2022.134608.
  6. “Bimetallic Catalyzed Synthesis of 2-Arylindoles”, Rita Ferro, Nuno Viduedo, A. Sofia Santos, Artur M. S. Silva, Beatriz Royo, M. Manuel B. Marques, Synthesis, 2023, 55, 3625-3631, https://doi.org/10.1055/a-2035-6420.
  7. “Selective Induction of DNA Damage and Cell Cycle Arrest Mediated by Chromone-Triazole Dyads Derivatives: Effects on Breast and Prostate Cancer Cells”, Liza Saher, Fátima L. Monteiro, Djenisa H. A. Rocha, Hélio M. T. Albuquerque, Artur M. S. Silva, Luisa A. Helguero, Chem. Biodiversity, 2023, 20, e202300251 (1 of 9).
  8. “Discovery of thiazolo[5,4-c]isoquinoline based compounds as acetylcholinesterase inhibitors through computational target prediction, molecular docking and bioassay”, Letícia D. Costa, Carlos F.M. Silva, Diana C.G.A. Pinto, Artur M.S. Silva, Florbela Pereira, Maria Amparo F. Faustino, Augusto C. Tomé, J. Mol. Struct., 2023, 1291, 136088. https://doi.org/10.1016/j.molstruc.2023.136088
  9. “Facile Access to Structurally Diverse Antimalarial Indoles Using a One-Pot A3 Coupling and Domino Cyclization Approach”, Gustavo da Silva, André F. S. Luz, Denise Duarte, Diana Fontinha, Vera L. M. Silva, Filipe A. Almeida Paz, Ana M. Madureira, Sandra Simões, Miguel Prudêncio, Fátima Nogueira, Artur M. S. Silva, Rui Moreira, ChemMedChem, 2023, e202300264, https://doi.org/10.1002/cmdc.202300264.
  10. “Bis-chalcones: A review of synthetic methodologies and anti-inflammatory effects”, Rui Pereira, Artur M. S. Silva, Daniela Ribeiro, Vera L.M. Silva, Eduarda Fernandes, Eur. J. Med. Chem., 2023, 252, 115280.
  11. “Highlights on the General Preference for Multi-Over Mono-Coupling in the Suzuki–Miyaura Reaction”, Carlos F. R. A. C. Lima, Marco A. L. Lima, J. Ricardo M. Pinto, M. Gabriela T. C. Ribeiro, Artur M. S. Silva, Luís M. N. B. F. Santos, Catalysts, 2023, 13, 928. https://doi.org/10.3390/catal13060928.
  12. “Pentaketides and 5-p-Hydroxyphenyl-2-pyridone Derivative from the Culture Extract of a Marine Sponge-Associated Fungus Hamigera avellanea KUFA0732”, Rotchana Klaram, Tida Dethoup, Fátima P. Machado, Luís Gales, Decha Kumla, Salar Hafez Ghoran, Emília Sousa, Sharad Mistry, Artur M. S. Silva, Anake Kijjoa, Mar. Drugs, 2023, 21, 344. https://doi.org/10.3390/md21060344.
  13. “Synthesis, characterization of new α-quinolin-3-yl-α-(aminoamides, aminoesters) and bi-heterocyclic aromatic systems from gem-dicyanoepoxides and their pharmacological activity as antioxidant and antifungal agents”, Houria Bouria, Hayette Alliouche, Mohamed Imed Chouiter, Abdelmalek Bouraiou, Hocine Merazig, Artur M. S. Silva, Ali Belfaitah, J. Heterocycl. Chem., 2023, 60, 1778–1792, https://doi.org/10.1002/jhet.4720.
  14. “Excited-State Proton Transfer in Luminescent Dyes: From Theoretical Insight to Experimental Evidence”, Luis F. B. Fontes, Joao Rocha, Artur M. S. Silva, Samuel Guieu, Chem. Eur. J., 2023, e202301540, https://doi.org/10.1002/chem.202301540.
  15. “Application of the Heck Reaction for the Synthesis of C-Glycosyl Phenolic Compounds”, Sara M. Tomé, Raquel G. Soengas, Artur M. S. Silva, Synthesis, 2023, 55(23), 4000-4010, https://doi.org/10.1055/a-2147-2788.
  16. “Exploring Thermomyces lanuginosus Lipase (TLL)-PdNPs Nanohybrid as Suitable Catalyst for One-pot Synthesis of Bis(3-indolyl)phenylmethane”, A. Sofia Santos, Noelia Losada-Garcia, Carla Garcia-Sanz, Artur M. S. Silva, M. Manuel B. Marques, Jose M. Palomo, ChemCatChem, 2024, e202300748 (1 of 7). https://doi.org/10.1002/cctc.202300748.
  17. “Opuntia ficus-indica seed pomace extracts with high UV-screening ability in a circular economy approach for body lotions with solar protection”, Ricardo M. Ferreira, Noélia Flórez-Fernández, Artur S. Silva, Jorge A. Saraiva, F.L. Figueroa, J. Vega, M. Dolores Torres, Susana M. Cardoso, Herminia Domínguez, J. Ind. Eng. Chem., 2024, 130, 456–467; https://doi.org/10.1016/j.jiec.2023.09.052.
  18. “Recent Advances in Fluorescent Theranostics for Alzheimer’s Disease: A Comprehensive Survey on Design, Synthesis, and Properties”, Telmo N. Francisco, Daniela Malafaia, Lúcia Melo, Artur M. S. Silva, Hélio M. T. Albuquerque, ACS Omega, 2024, 9, 13556-13591; https://doi.org/10.1021/acsomega.3c10417.
  19. “Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates, Mariana Marques, Bruno Ramos, Hélio Albuquerque, Marisa Pereira, Diana Roberta Ribeiro, Alexandre Nunes, Jéssica Sarabando, Daniela Brás, Ana Rita Ferreira, Rui Vitorino, Maria João Amorim, Artur M.S. Silva, Ana Raquel Soares, Daniela Ribeiro, iScience, 2024, 27, 109100, https://doi.org/10.1016/j.isci.2024.109100.
  20. “Phytochemical Investigation and Biological Characaterization of Hedysarum pallidum, Amina Dob, Naima Rahmouni, Chawki Bensouici, Diana C. G. A. Pinto, Artur M. S. Silva, Zouhir Djerrou, Ouahiba Boumaza, Chem. Nat. Comp., 2024, 60, 336-339; https://doi.org/10.1007/s10600-024-04317-3.
  21. “Impact of Fe3O4-porphyrin hybrid nanoparticles on wheat: Physiological and metabolic advance”, Gonçalo Gamito, Carlos J. P. Monteiro, Maria Celeste Dias, Helena Oliveira, Artur M. S. Silva, Maria A. F. Faustino, Sónia Silva, J. Hazardous Mat., 2024, 471, 134243; https://doi.org/10.1016/j.jhazmat.2024.134243.
  22. “Production of Opuntia ficus-indica fortified breads: A comparative analysis of wheat and gluten-free varieties and the impact on phytochemicals and antioxidant capacity”, Ricardo M. Ferreira, Dulcineia F. Wessel, Artur M.S. Silva, Jorge A. Saraiva, Susana M. Cardoso, Food and Bioproducts Processing, 2024, 147, 251–263; https://doi.org/10.1016/j.fbp.2024.07.005.
  23. “An In-Depth Exploration of Six Decades of the Kröhnke Pyridine Synthesis”, Telmo N. Francisco, Hélio M. T. Albuquerque, Artur M. S. Silva, Chem. Eur. J., 2024, 30, e202401672 (1 of 25); https://doi.org/10.1002/chem.202401672.
  24. “Herbacetin Inhibits Human Fructose 1,6-Bisphosphatase Among a Panel of Chromone Derivatives and Pyrazoles, Demonstrating Positive Effects on Insulin-Resistant HepG2 Cells”, Sónia Rocha, Beatriz Vicente, Carina Proença, Vera L. M. Silva, Artur M. S. Silva, M. Luísa Corvo, Eduarda Fernandes, Marisa Freitas, Chem. Biol. & Drug Design, 2024, 104, e70017; https://doi.org/10.1111/cbdd.70017.
  25. “Bioprospecting a Natural Antioxidant Peptide for Tomato Biostimulation Under Water Limitations: Physiological Approach”, Sónia Silva, Cátia Teixeira, Maria Celeste Dias, Renato B. Pereira, Paula Gomes, Artur M. S. Silva, J. Plant Growth Regul., 2025, 44, 2569–2582, https://doi.org/10.1007/s00344-024-11569-4.
  26. “Styrylchromones: Biological Activities and Structure-Activity Relationship”, Mariana Lucas, Marisa Freitas, Artur M. S. Silva, Eduarda Fernandes, Daniela Ribeiro, ChemMedChem, 2025, e202400782 (1 of 43); https://doi.org/10.1002/cmdc.202400782.
  27. “1,3,5-Triazine: A Promising Molecular Scaffold for Novel Agents for the Treatment of Alzheimer’s Disease”, Carlos F. M. Silva, Ana P. D. de M. S. Guerrinha, Sofia Carvalho, Diana C. G. A. Pinto, Artur M. S. Silva, Int. J. Mol. Sci., 2025, 26, 882. https://doi.org/10.3390/ijms26030882.
  28. “The role of quinoline in the development of near-infrared fluorescent probes for diagnosis of Alzheimer’s disease”, Lúcia Melo, Artur M.S. Silva, Hélio M.T. Albuquerque, Eur. J. Med. Chem., 2025, 296, 117874, https://doi.org/10.1016/j.ejmech.2025.117874.
  29. “Single-Benzene Fluorophore with Enhanced Emission: Insights Into Photophysical Properties Through Proton Transfer Mapping”, Luís F. B. Fontes, João Rocha, Artur M. S. Silva, Samuel Guieu, Chem. Eur. J., 2025, 0, e202501178, https://doi.org/10.1002/chem.202501178.
  30. “Applying the Principles of Green Chemistry to Cyclopropanation”, Patrícia I. C. Godinho, Raquel G. Soengas , Artur M. S. Silva, Synthesis, 2025, 57, 1769-1790, https://doi.org/10.1055/a-2557-7569.
  31. “Nanoencapsulation of vitamin B12 with Opuntia ficus-indica seed oil for food supplements uses”, Ricardo M. Ferreira, Andreia Granja, Artur M.S. Silva, Jorge A. Saraiva, Salette Reis, Susana M. Cardoso, Food and Bioprod. Processing, 2025, 150, 275–284, https://doi.org/10.1016/j.fbp.2025.01.016.
  32. “Synthesis of novel quinoline-thiazolobenzimidazolone hybrids as anticancer agents through caspase-dependent apoptosis”, Houria Bouria, Hayette Alliouche, Mohamed Imed Chouiter, Ali Belfaitah, Teresa Pacheco, Viktor Gala, David Pereira, Artur M. S. Silva, Future Med. Chem., 2025, 17, 543-555, https://doi.org/10.1080/17568919.2025.2470112.
  33. “Design, synthesis, and comprehensive evaluation of novel imidazole–chromone hybrids as potent cholinesterase and α-glucosidase inhibitors”, Massaab Khalfaoui, Wahiba Frites, Arif Mermer, Dursun Kisa, Buket Yildirim, Mohamed I. Chouiter, Artur M.S. Silva, Houssem Boulebd, Eur. J. Med. Chem., 2025, 297, 5, 117927, https://doi.org/10.1016/j.ejmech.2025.117927.
  34. “Hemisynthesis of monoterpene-containing pyridin-2-one, pyrano[2,3-c]pyrazole and dicarbamate derivatives: in vitro and in silico anti-inflammatory activity”, Maamar Haffas, Naima Benkiki, Farid Chebrouk, Ramzi Maadadi, Rafik Menacer, Chaima Mouffouk, Zahia Kabouche, Ricardo F. Mendes, Filipe A. Almeida Paz, Liza Saher, Khaldoun Bachari, Oualid Talhi, Artur M.S. Silva, Joana L.C. Sousa, J. Mol. Struct., 2025, 1331, 141565, https://doi.org/10.1016/j.molstruc.2025.141565.
  35. “Targeted synthesis of alkylated coumarin derivatives as SARS-CoV-2 main protease inhibitors: Cascade addition, alkylation, molecular docking, and ADME evaluation”, Lakhder Jaafar, Mokhtar Boualem Lahrech, Amar Djemoui, Mohamed Kacimi El Hassani, Lazhar Bechki, Souli Lahcene, Mohammed Messaoudi, Huda Alsaeedi, Artur M.S. Silva, Jean-Patrick Joly, Ahmed Barhoum, J. Mol. Struct., 2025, 1341, 142677, https://doi.org/10.1016/j.molstruc.2025.142677.


Profile Details

http://orcid.org/0000-0003-2861-8286
https://www.ua.pt/pt/p/10309368
https://www.cienciavitae.pt/3C16-EC9B-81D7
Researcher ID: L-9222-2014
Scopus Author ID: 7403222204

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