Dr. Anskar Yu-Hung Leung

The University of Hong Kong, China

Email: [email protected]

Qualifications

2006 M.D., University of Hong Kong, China

1993 Ph.D., Chinese University of Hong Kong, China

Publications (Selected)

1. Chen, Y. A., Chan, K. C., Sin, C. F., et al. (2026). Vulnerability of SRSF2-mutated chronic myelomonocytic leukemia to perturbation of the cGAS-STING pathway. Blood Advances, 10(3).
2. Lam, W. K., Yuen, C. M., Tsui, L. L. C., et al. (2025). All-in-one -- SEA, β-thalassaemia and haemoglobinopathy screening through the novel a-thalassaemia early eluting peak. British Journal of Haematology, 207, S28–S28.
3. Zeidner, J. F., Sallman, D. A., Récher, C., et al. (2025). Magrolimab plus azacitidine vs physician's choice for untreated TP53-mutated acute myeloid leukemia: the ENHANCE-2 study. Blood, 146(5), 590–600.
4. Ng, N. K. L., Lam, S. S. Y., Zheng, L. C., et al. (2025). Mechanism of Initial Favorable Response to Decitabine in TP53-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse. Clinical Cancer Research, 31(14), 3048–3061.
5. Fang, Q. W., Fung, C. Y., Wang, J. Q., et al. (2025). Hypomethylating agent versus venetoclax combination: an electronic health records-based target trial emulation among Asian elderly patients with newly diagnosed acute myeloid leukaemia in Hong Kong. Therapeutic Advances in Hematology, 16, Article 20406207251346914.
6. Tsui, S. P., Lam, S. S. Y., Au, C. H., et al. (2025). Early measurable residual disease detection post-haematopoietic stem cell transplantation in acute myeloid leukaemia. Therapeutic Advances in Hematology, 16, Article 20406207251389815.
7. Lam, S., Zheng, L. C., Wong, K. K. W., et al. (2024). Combination of Quizartinib and Omacetaxine Mepesuccinate (QUIZOM) As an Effective Treatment Remodels Proteostasis and Triggers Inflammatory Response in FLT3-ITD AML. Blood, 144, 1510–1511.
8. Lam, S., Poon, A. C. H., Chan, K. C., et al. (2024). In Vitro Drug Profiling to Guide Treatment for Relapse/Refractory AML. Blood, 144, 3603–3604.
9. Lam, W., Chan, K. C., Tong, K. W., et al. (2024). Inhibition of Threonine Tyrosine Kinase Suppressed TP53-mutated Acute Myeloid Leukaemia Via Synergism with Venetoclax and Activation of the Cgas-Sting Pathway. Blood, 144, 1399–1400.
10. Ng, K. L. N., Ng, L., Lam, S., et al. (2024). Activation of Cgas-Sting Pathway By Hypomethylating Agent in TP53 Mutated MDS/AML. Blood, 144, 2726–2727.
11. Tsui, S. P., Ip, H. W., Lam, S., et al. (2024). Measurable Residual Disease Detection on Day 30 Post Haematopoietic Stem Cell Transplantation Predicts Clinical Outcome in Acute Myeloid Leukemia. Blood, 144, 1569–1569.
12. Zeng, X. Y., Tong, K. W., Chan, K. C., et al. (2024). HPKI Inhibition and Venetoclax Combination Suppressed AML By Enhancing Cytotoxic T-Cell Response to Leukaemia. Blood, 144, 2763–2763.
13. Cheung, H. L., Wong, Y. H., Li, Y. Y., et al. (2025). Microenvironment matters: In vitro 3D bone marrow niches differentially modulate survival, phenotype and drug responses of acute myeloid leukemia (AML) cells. Biomaterials, 312, Article 122719.
14. Man, C. H., Lam, W., Dang, C. C., et al. (2023). Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML. Blood, 142(23), 2002–2015.
15. Lam, S. S. Y., Tsui, S. P., Fung, C. Y., et al. (2024). Distinct karyotypic and mutational landscape in trisomy AML. British Journal of Haematology, 204(3), 939–944.
16. Ho, S. C., Li, G. H. Y., Leung, A. Y. H., et al. (2022). Unravelling genetic causality of haematopoiesis on bone metabolism in human. European Journal of Endocrinology, 187(6), 765–775.
17. Man, C. H., Zeng, X. Y., Lam, W., et al. (2022). Regulation of proton partitioning in kinase-activating acute myeloid leukemia and its therapeutic implication. Leukemia, 36(8), 1990–2001.
18. Sing, C. W., Tang, C. T. L., Chui, C. S. L., et al. (2022). COVID-19 vaccines and risks of hematological abnormalities: Nested case-control and self-controlled case series study. American Journal of Hematology, 97(4), 470–480.
19. Man, C. H., Mercier, F. E., Liu, N. A., et al. (2022). Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth. Blood, 139(4), 502–522.
20. Guo, Y. H., Cheng, B. Y. L., Wang, D. D., et al. (2020). Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium. Stem Cell Reports, 14(4), 575–589.

Profile Details
https://theleunglab.hku.hk/professor-anskar-leung-yu-hung
https://scholar.google.com/citations?user=BM3Ftt4AAAAJ&hl=en
https://www.researchgate.net/scientific-contributions/Anskar-Yu-Hung-Leung-2131207365

WOS ResearcherID: C-4335-2009