Biography

Prof. Al Moustafa Ala-Eddin

Qatar University, Qatar


Email: [email protected]


Qualifications


1992 Ph.D., Université Paris XIII, France

1988 M.Sc., Université Paris XIII, France

1982 B.Sc., Aleppo University, Syria


Publications (selected)

  1. Hussein, O. J., Kheraldine, H., Elkhalifa, D., Hassan, A. F., Abunada, H. H., Alali, F., Al Moustafa, A.-E., & Khalil, A. (2026). Design, synthesis and biological evaluation of novel chalcone analogs against castration-resistant prostate cancer. Biomedicine & Pharmacotherapy, 199, 119447. https://doi.org/10.1016/j.biopha.2026.119447
  2. Kheraldine, H., Hassan, A. F., Saeed, S., Merhi, M., Miles Mateo, J., Ulamec, M., Peric-Balja, M., Vranic, S., Al-Thawadi, H., & Al Moustafa, A.-E. (2025). Neratinib and metformin: A novel therapeutic approach against HER2-positive breast cancer. Biomedicine & Pharmacotherapy, 187, 118034. https://doi.org/10.1016/j.biopha.2025.118034
  3. Hussein, O. J., Elkhalifa, D., Hassan, A. F., Alali, F., Al Moustafa, A.-E., & Khalil, A. (2025). The role of natural chalcones and their derivatives in targeting prostate cancer: Recent updates. International Journal of Molecular Sciences, 26(24), 12082. https://doi.org/10.3390/ijms262412082
  4. Saeed, S., Hassan, A. F., Suliman, A., Al Moustafa, A.-E., & Alali, F. (2025). Methanolic leaves extract of Ziziphus spina-christi inhibits cell proliferation and migration of HER2-positive breast cancer via p38 MAPK signaling pathway. International Journal of Molecular Sciences, 26(2), 654. https://doi.org/10.3390/ijms26020654
  5. Fernandes, Q., Inchakalody, V. P., Mestiri, S., Bedhiafi, T., Hydrose, S., Bashraheel, S. S., Merhi, M., Dermime, S., & Al Moustafa, A.-E. (2025). Crosstalk between the oncoproteins of high-risk Human Papillomaviruses types 16 and 18 in colorectal cancer cell models. Expert Review of Proteomics, 22(2), 71-84. https://doi.org/10.1080/14789450.2025.2455104
  6. Kheraldine, H., Gupta, I., Cyprian, F. S., Vranic, S., Al-Farsi, H. F., Merhi, M., Dermime, S., & Al Moustafa, A.-E. (2024). Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways. Cancer Cell International, 24, 94. https://doi.org/10.1186/s12935-023-03195-z
  7. Fernandes, Q., Gupta, I., Murshed, K., Abo Samra, H., Al-Thawadi, H., Vranic, S., Petkar, M., Babu, G. R., & Al Moustafa, A.-E. (2023). Incidence and association of high-risk HPVs and EBV in patients with advanced stages of colorectal cancer from Qatar. Human Vaccines & Immunotherapeutics, 19(2), 2220626. https://doi.org/10.1080/21645515.2023.2220626
  8. Fernandes, Q., Gupta, I., Murshed, K., Abo Samra, H., Al-Thawadi, H., Vranic, S., Petkar, M., Babu, G. R., & Al Moustafa, A.-E. (2023). Coinfection of HPVs is associated with advanced stage in colorectal cancer patients from Qatar. Pathogens, 12(3), 424. https://doi.org/10.3390/pathogens12030424
  9. Padmanabhan, R., Kheraldine, H., Gupta, I., Meskin, N., Hamad, A., Vranic, S., & Al Moustafa, A.-E. (2022). A mathematical model for exploring the dynamics of tumor-immune interactions in the context of combination therapies for breast cancer. Frontiers in Oncology, 12, 977664. https://doi.org/10.3389/fonc.2022.977664
  10. Rizeq, B., Gupta, I., Kheraldine, H., Elkhalifa, D., Al-Farsi, H. F., Al Moustafa, A.-E., & Khalil, A. (2021). Novel nitrogen-based chalcone analogs provoke substantial apoptosis in HER2-positive human breast cancer cells via JNK and ERK1/ERK2 signaling pathways. International Journal of Molecular Sciences, 22(17), 9621. https://doi.org/10.3390/ijms22179621
  11. Kheraldine, H., Gupta, I., Alhussain, H., Jabeen, A., Cyprian, F. S., Akhtar, S., Al Moustafa, A.-E., & Rachid, O. (2021). Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways. Computational and Structural Biotechnology Journal, 19, 2881-2890. https://doi.org/10.1016/j.csbj.2021.05.011
  12. Nagi, K., Gupta, I., Jurdi, N., Jabeen, A., Yasmeen, A., Batist, G., Vranic, S., & Al Moustafa, A.-E. (2021). Identification of deregulated molecular mechanisms in ovarian cancer caused by high-risk HPVs and EBV. Cancer Cell International, 21(1), 308. https://doi.org/10.1186/s12935-021-02009-4
  13. Gupta, I., Ulamec, M., Peric-Balja, M., Ramic, S., Al Moustafa, A.-E., Vranic, S., & Al-Farsi, H. F. (2021). Presence of high-risk HPVs, EBV, and MMTV in human triple-negative breast cancer. Human Vaccines & Immunotherapeutics, 17(11), 4457-4466. https://doi.org/10.1080/21645515.2021.1975452
  14. Gupta, I., Nasrallah, G. K., Sharma, A., Jabeen, A., Smatti, M. K., Al-Thawadi, H. A., Sultan, A. A., Alkhalaf, M., Vranic, S., & Al Moustafa, A.-E. (2020). Co-prevalence of human Papillomaviruses (HPV) and Epstein-Barr virus (EBV) in healthy blood donors from diverse nationalities in Qatar. Cancer Cell International, 20, 107. https://doi.org/10.1186/s12935-020-01190-2
  15. Malki, M. I., Gupta, I., Fernandes, Q., Aboulkassim, T., Yasmeen, A., Vranic, S., Al Moustafa, A.-E., & Al-Thawadi, H. A. (2020). Co-presence of Epstein-Barr virus and high-risk human papillomaviruses in Syrian colorectal cancer samples. Human Vaccines & Immunotherapeutics, 16(10), 2403-2407. https://doi.org/10.1080/21645515.2020.1746659
  16. Jabeen, A., Sharma, A., Gupta, I., Kheraldine, H., Vranic, S., Al Moustafa, A.-E., & Al Farsi, H. F. (2020). Elaeagnus angustifolia plant extract inhibits epithelial-mesenchymal transition and induces apoptosis via HER2 inactivation and beta-catenin nuclear translocation in colorectal cancer cells. Molecules, 25(18), 4308. https://doi.org/10.3390/molecules25184308
  17. Fernandes, Q., Gupta, I., Vranic, S., & Al Moustafa, A.-E. (2020). Human papillomaviruses and Epstein-Barr virus interactions in colorectal cancer: A brief review. Pathogens, 9(4), 300. https://doi.org/10.3390/pathogens9040300
  18. Elkhalifa, D., Siddique, A. B., Qusa, M., Cyprian, F. S., El Sayed, K., Alali, F., Al Moustafa, A.-E., & Khalil, A. (2020). Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer. European Journal of Medicinal Chemistry, 187, 111954. https://doi.org/10.1016/j.ejmech.2019.111954
  19. Cyprian, F. S., Al-Farsi, H. F., Vranic, S., Akhtar, S., & Al Moustafa, A.-E. (2018). Epstein-Barr virus and human papillomaviruses interactions and their roles in the initiation of epithelial-mesenchymal transition and cancer progression. Frontiers in Oncology, 8, 111. https://doi.org/10.3389/fonc.2018.00111
  20. Akhtar, S., Vranic, S., Cyprian, F. S., & Al Moustafa, A.-E. (2018). Epstein-Barr virus in gliomas: Cause, association, or artifact? Frontiers in Oncology, 8, 123. https://doi.org/10.3389/fonc.2018.00123


Profile Details
https://www.qu.edu.qa/medicine/faculty/current-faculty-&-staff
https://scholar.google.com/citations?user=25s5dVIAAAAJ&hl=en
https://www.researchgate.net/profile/Ala-Eddin-Al-Moustafa

WOS ResearcherID：DVB-7388-2022

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