Biography

Dr. Alexander Y. Tsygankov

Temple University, USA


Email: [email protected]


Qualifications

1988  Ph.D., Bach Institute of Biochemistry, Russia

1982  M.Sc., Moscow University, Russia

1980  B.Sc., Moscow University, Russia


Publications (Selected)


  1. Elzoheiry, M. A., Dangelmaier, C. A., Vajipayajula, D. N., et al. (2025). Phosphorylation at Y317 on Syk negatively regulates both ITAM-and hemITAM-mediated signaling and function in platelets. Blood Advances, 9(21), 5626-5637.
  2. Dangelmaier, C., Vari, H. R., Vajipayajula, D. N., et al. (2024). Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets. Platelets, 35(1), Article 2369766.
  3. Tsygankov, A. Y. (2024). Role of Tula-Family Proteins in Cell Signaling and Activation: Advances and Challenges. International Journal of Molecular Sciences, 25(8), Article 4434.
  4. Singh, P. K., Dangelmaier, C. A., Vari, H. R., et al. (2023). Biochemical characterization of spleen tyrosine kinase (SYK) isoforms in platelets. Platelets, 34(1), Article 2249549.
  5. Dangelmaier, C. A., Patchin, M., Vajipayajula, D. N., et al. (2023). Phosphorylation of spleen tyrosine kinase at Y346 negatively regulates ITAM-mediated signaling and function in platelets. Journal of Biological Chemistry, 299(7), Article 104865.
  6. Tsygankov, A. Y. (2023). TULA Proteins in Men, Mice, Hens, and Lice: Welcome to the Family. International Journal of Molecular Sciences, 24(11), Article 9126.
  7. Kunapuli, S. P., & Tsygankov, A. Y. (2022). TULA-Family Regulators of Platelet Activation. International Journal of Molecular Sciences, 23(23), Article 14910.
  8. Kostyak, J. C., Mauri, B., Dangelmaier, C., et al. (2022). Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets. Journal of Biological Chemistry, 298(8), Article 102189.
  9. Albayati, S., Vemulapalli, H., Tsygankov, A. Y., et al. (2021). P2Y12 antagonism results in altered interactions between platelets and regulatory T cells during sepsis. Journal of Leukocyte Biology, 110(1), 141-153.
  10. Tripathi, A., Liverani, E., Tsygankov, A. Y., et al. (2020). Iron alters the cell wall composition and intracellular lactate to affectCandida albicanssusceptibility to antifungals and host immune response. Journal of Biological Chemistry, 295(29), 10032-10044.
  11. Tsygankov, A. Y. (2020). TULA proteins as signaling regulators. Cellular Signalling, 65, Article 109424.
  12. Vemulapalli, H., Albayati, S., Patwa, V. C., et al. (2020). ADP exerts P2Y12 -dependent and P2Y12 -independent effects on primary human T cell responses to stimulation. Journal of Cell Communication and Signaling, 14(1), 111-126.
  13. Vemulapalli, H., Albayati, S., Tsygankov, A., et al. (2019). PLATELETS INFLUENCE REGULATORY T CELL PROLIFERATION AND ACTIVITY DURING SEPSIS. Shock, 51(6, Suppl. 1), 129.
  14. Tsygankov, A. Y. (2019). TULA-family proteins: Jacks of many trades and then some. Journal of Cellular Physiology, 234(1), 274-288.
  15. Vemulapalli, H., Samara, A., Tsygankov, A. Y., et al. (2018). Blockade of the P2Y12 signaling Pathway with Clopidogrel Restrains Treg Proliferation In Vivo during Sepsis and in Vitro. Blood, 132(Suppl. 1), 2413.
  16. Sarkar, A., Shukla, S. K., Alqatawni, A., et al. (2018). RETRACTED: The Role of Allograft Inflammatory Factor-1 in the Effects of Experimental Diabetes on B Cell Functions in the Heart (Retracted Article). Frontiers in Cardiovascular Medicine, 5, Article 126.
  17. Kostyak, J., Mauri, B. R., Dangelmaier, C. A., et al. (2017). TULA-2 Deficiency Enhances Platelet Response to CLEC-2 Agonists. Blood, 130(Suppl. 1), 2302.
  18. Sarkar, A., Shukla, S. K., Sikder, K., et al. (2017). Inhibition of Allograft Inflammatory Factor-1 Attenuates B Cell Development and Infiltration to Cardiac Tissue During the Development of Diabetic Cardiomyopathy. FASEB Journal, 31(Suppl. 1), 1079.5.
  19. Reppschläger, K., Gosselin, J., Dangelmaier, C. A., et al. (2016). TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. Journal of Biological Chemistry, 291(43), 22427–22441.
  20. Newman, T. N., Liverani, E., Ivanova, E., et al. (2014). Members of the novel UBASH3/STS/TULA family of cellular regulators suppress T-cell-driven inflammatory responses in vivo. Immunology and Cell Biology, 92(10), 837–850.
  21. Chen, X., Ren, L., Kim, S., et al. (2010). Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. Journal of Biological Chemistry, 285(41), 31268–31276.
  22. Thomas, D. H., Getz, T. M., Newman, T. N., et al. (2010). A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets. Blood, 116(14), 2570–2578.
  23. Tsygankov, A. Y. (2009). Current developments in anti-HIV/AIDS gene therapy. Current Opinion in Molecular Therapeutics, 10(2), 137–149.
  24. Smirnova, E. V., Collingwood, T. S., Bisbal, C., et al. (2008). TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion. Virology, 372(1), 10–23.
  25. Collingwood, T. S., Smirnova, E. V., Bogush, M., et al. (2007). T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis. Journal of Biological Chemistry, 282(42), 30920–30928.
  26. Raymond, A. D., Hasham, M., Tsygankov, A. Y., et al. (2007). Herpesvirus saimiri terminal membrane proteins modulate HIV-1 replication by altering Nef and Tat functions. Current HIV Research, 5(1), 79–86.
  27. Feshchenko, E. A., Smirnova, E. V., Swaminathan, G., et al. (2004). TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin. Oncogene, 23(27), 4690–4706.
  28. Feshchenko, E. A., Langdon, W. Y., & Tsygankov, A. Y. (1998). Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells. Journal of Biological Chemistry, 273(14), 8323–8331.


profiles Details
https://medicine.temple.edu/directory/alexander-y-tsygankov-phd
https://scholar.google.com/citations?user=tPgsFCgAAAAJ&hl=en
https://www.researchgate.net/profile/Alexander-Tsygankov

WOS ResearcherID: K-6205-2017


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