Prof. Tarik Möröy

Université de Montréal, Canada

Email: [email protected]

Qualifications

1987 Ph.D., Biochemistry, Ludwig-Maximilians-University, Germany

1984 M.Sc., Biochemistry, Organic Chemistry and Microbiology, Eberhard-Karls-University Tübingen, Germany

Publications (Selected)

1. Saba, I, Kosan C, Vassen L and Möröy T.IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1. Blood, 2011, in press
2. Khandanpour C, Kosan C, Gaudreau MC, Dührsen U, Zeng H and Möröy T.Growth factor independence 1 (Gfi1) protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease. Stem Cells, 2010, Dec 9. [Epub ahead of print]
3. Kosan C, Saba I, Godmann M, Herold S, Herkert B, Eilers M and Möröy T.The BTB/POZ domain protein Miz-1 (Zbtb17) is required to regulate IL-7 receptor signaling at early commitment stages of B cell differentiation. Immunity, 2010, Dec 14;33(6):917-28.
4. Khandanpour C, Sharif-Askari E, Gaudreau MC, Vassen L, Zhu J, Paul W, Okoyama T, Kosan C, and Möröy T. Evidence that Growth factor independence 1b (Gfi1b) regulates dormancy and peripheral blood mobilization of hematopoietic stem cells Blood, 2010, 9 December 2010, Vol. 116, No. 24, pp. 5149-5161. (Faculty 1000 Rating 6)
5. Sharif-Askari E, Vassen L, Kosan C, Khandanpour C, Gaudreau MC, Heyd F, Okayama T, Jin J, Rojas MEB,Grimes HL, Zeng H and Möröy T. Zinc finger protein Gfi1 controls the endotoxin-mediated TLR inflammatory response by antagonizing NFkB p65. Mol. Cell. Biol., 2010, Aug;30(16):3929-42.
6. Van Riggelen J, Müller J, Otto T, Beuger V, Yetil A, Choi P, Kosan C, Möröy T, Felsher D, and Eilers M. The interaction between Myc and Miz1 is required to antagonize TGF beta-dependent autocrine signaling during lymphoma formation and maintenance Genes & Development, 2010 Jun 15;24(12):1281-94.
7. Khandanpour C,Thiede C, Valk, PJM, Sharif-Askari E, Nückel H, Lohmann D, Horsthemke B, Siffert W, Neubauer A, Grzeschik KH, Bloomfield CD, Marcucci G, Maharry K, Slovak ML, van der Reijden BA, Jansen JA, Schackert HK, Afshar K, Schnittger S, Peeters JK, Frank Kroschinsky F, Ehninger G, Lowenberg B, Dührsen D and Möröy T. A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia.Blood, 2010, Mar 25;115(12):2462-72.
8. Ichiyama K, Hashimoto M, Sekiya T, Nakagawa R, Wakabayashi Y, Ingrid S, Möröy T, and Yoshimura A. Gfi1 negatively regulates Th17 differentiation by inhibiting RORγt activity Int J. Immunol, 2009, Jul;21(7):881-9.
9. Vassen L, Khandanpour C, Ebeling P, van der Reijden BA, Jansen JH, Mahlmann S, Dührsen U and Möröy T. Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia. Int. J. Hematol. 2009, May;89(4):422-30