Prof. Tarik Möröy

Université de Montréal, Canada

Email: [email protected]

Qualifications

1987 Ph.D., Biochemistry, Ludwig-Maximilians-University, Germany

1984 M.Sc., Biochemistry, Organic Chemistry and Microbiology, Eberhard-Karls-University Tübingen, Germany

Publications (Selected)

1. Fraszczak, J., Obwegs, D., & Arman, K., et al. (2026). GFI1 as a novel regulator of γδ T cell development and the IL-17/IFNγ lineage commitment. Frontiers in Immunology, 17, Article 1849622.
2. Fraszczak, J., Vadnais, C., & Rashkovan, M., et al. (2026). Correction: Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice. Leukemia, 40(4), 853–853.
3. Ross, J., Piskor, E. M., & Joly-Beauparlant, C., et al. (2026). MIZ-1 controls transcriptional programs required for BCR signaling, actin dynamics, and naïve B cell survival. Frontiers in Immunology, 17, Article 1758550.
4. Arman, K., Ross, J., & Piskor, E. M., et al. (2025). The lncRNA ELDR suppresses tumorigenicity of AML by interfering with DNA replication and chromatin accessibility. Blood Advances, 9(23), 6158–6174.
5. Beauchemin, H., Dalloul, Z., & Piskor, E. M., et al. (2025). Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxidative stress and impedes tumor progression in xenografts. Frontiers in Cell and Developmental Biology, 13, Article 1642006.
6. Huang, Q., Cao, W. H. J., & Curio, S., et al. (2024). GFI1B specifies developmental potential of innate lymphoid cell progenitors in the lungs. Science Immunology, 9(95), Article eadj2654.
7. Subramani, P. G., Fraszczak, J., & Helness, A., et al. (2024). Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation. EMBO Reports, 25(6), 2662–2697.
8. Frank, D., Patnana, P. K., & Vorwerk, J., et al. (2023). Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy. Blood, 142(25), 2175–2191.
9. Lacroix, M., Beauchemin, H., & Khandanpour, C., et al. (2023). The RNA helicase DDX3 and its role in c-MYC driven germinal center-derived B-cell lymphoma. Frontiers in Oncology, 13, Article 1148936.
10. Möröy, T., & Khandanpour, C. (2023). New emerging functions of transcription factors and RNA-binding proteins in the development of hematological malignancies. Frontiers in Oncology, 13, Article 1256461.
11. Subramani, P. G., Fraszczak, J., & Helness, A., et al. (2023). A conserved role of hnRNPL in regulating alternative splicing of transcriptional regulators necessary for B cell activation. bioRxiv, 2023.09.24.559201.
12. Helness, A., Fraszczak, J., & Joly-Beauparlant, C., et al. (2022). Author Correction: GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors. Communications Biology, 5, Article 922.
13. Lacroix, M., Beauchemin, H., & Fraszczak, J., et al. (2022). The X-linked helicase DDX3X is required for lymphoid differentiation and MYC-driven lymphomagenesis. Cancer Research, 82(17), 3172–3186.
14. Lacroix, M., Beauchemin, H., & Möröy, T. (2022). DDX3: A relevant therapeutic target for lymphoma? Expert Opinion on Therapeutic Targets, 26(12), 1037–1040.
15. Piskor, E. M., Ross, J., & Möröy, T., et al. (2022). Myc-interacting zinc finger protein 1 (Miz-1) is essential to maintain homeostasis and immunocompetence of the B cell lineage. Biology, 11(4), Article 504.
16. Winkler, R., Mägdefrau, A. S., & Piskor, E. M., et al. (2022). Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition. Oncogene, 41(40), 4560–4572.
17. Helness, A., Fraszczak, J., & Joly-Beauparlant, C., et al. (2021). GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors. Communications Biology, 4(1), Article 1356.

Profile Details
https://microbiologie.umontreal.ca/recherche/professeurs-chercheurs/tarik-moroy/
https://www.moroylab.org/tarik-moroy/
https://scholar.google.com/citations?user=mtNTcfkAAAAJ&hl=en

WOS ResearcherID: D-9923-2011