Dr. Robert Paul Coppes

Department of Radiation Oncology

University of Groningen, Netherlands

Email: [email protected]

Qualifications

1993 Ph.D., Faculty of Mathematics and Natural Sciences, University of Groningen

1988 M.Sc., Neuropharmacology and Neurophysiology, behavioural physiology, University of Groningen

Publications (Selected)

1. Hajiabbas, M., Pelissari, C., & Parisis, D., et al. (2026). Hyaluronic Acid-silk Fibroin Hydrogel for Salivary Gland Tissue Engineering. Advanced Healthcare Materials, 15(23).
2. Maturi, R., Cinat, D., & Bruin, A. L. J.-D., et al. (2026). Radiation-induced interferon-I response impairs thyroid organoid function. Radiotherapy and Oncology, 218, Article 111453.
3. Jiang, Y., Guerra, D. B., & Voshart, D. C., et al. (2026). Differential synaptic signaling responses in human cortical organoids after photon and proton irradiation. Stem Cell Reports, 21(2), Article 102777.
4. Maturi, R., Esposito, M., & Coppes, R. P., et al. (2026). lncRNAs: a new generation of targets and biomarkers in thyroid cancer. European Thyroid Journal, 15(1), Article ETJ250290.
5. Jiang, Y., Voshart, D. C., & Gustinelli, A., et al. (2026). Brain irradiation drives remote liver changes via senescence-independent mechanisms. Radiotherapy and Oncology, 216, Article 111373.
6. Cinat, D., van der Wal, R., & Baanstra, M., et al. (2025). IFN-I signaling enhances salivary gland stem and progenitor cell activity after irradiation. Science Signaling, 18(913), Article eady0398.
7. Cinat, D., Maturi, R., & Gunawan, J. P., et al. (2026). Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage. EMBO Journal, 45(2), 374–393.
8. Jager, E. C., Sondorp, L. H. J., & Maturi, R., et al. (2025). Patient-derived medullary thyroid cancer organoids: a potential model for mechanistic studies on diagnostics and therapy. European Thyroid Journal, 14(5), Article e240405.
9. Boersma, L. J., Hessels, A., & Roberti, S., et al. (2025). Selection of patients for proton therapy to reduce risk of second primary lung and breast cancer. Radiotherapy and Oncology, 210, Article 110998.
10. Soto-Gamez, A., Terpstra, J. H., & Tesa, C., et al. (2025). GENERATION OF PLURIPOTENT STEM CELL-DERIVED SALIVARY GLAND PROGENITOR CELLS FOR TRANSPLANTATION IN SJOGREN'S DISEASE. Annals of the Rheumatic Diseases, 84.
11. Aalam, S. M. M., Varela, A. R., & Khaderi, A., et al. (2025). Establishment of salivary tissue-organoid biorepository: characterizing salivary gland stem/progenitor cells and novel differentiation marker PSMA/FOLH1. npj Regenerative Medicine, 10(1), Article 23.
12. de Koster, R. J. C., Gunawan, J. P., & Peters, H., et al. (2025). Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations. Clinical and Translational Radiation Oncology, 53, Article 100970.
13. Wiedemann, J., Brouwer, U., & Sillje, H. H. W., et al. (2025). Combination of Captopril, Ambrisentan and Sildenafil mitigates long-term side effects of combined heart and lung irradiation. Radiotherapy and Oncology, 206, S3942–S3943.
14. Verstegen, M. M. A., Coppes, R. P., & Beghin, A., et al. (2025). Clinical applications of human organoids. Nature Medicine, 31(2), 409–421.
15. Wiedemann, J., Paruchuru, S. K., & den Boef, L. E., et al. (2025). Sparing of the Heart Facilitates Recovery From Cardiopulmonary Side Effects After Thoracic Irradiation. International Journal of Radiation Oncology Biology Physics, 121(1), 191–201.
16. Rijn-Dekker, M. I. V., la Bastide-van Gemert, S., & Stokman, M. A., et al. (2024). Radiation-induced Xerostomia is Related to Stem Cell Dose-dependent Reduction of Saliva Production. International Journal of Radiation Oncology Biology Physics, 120(3), 772–782.
17. Chen, D., Zhao, C., & Zhang, J., et al. (2024). Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms. Advanced Science, 11(32).
18. Radstake, W. E., Parisi, A., & Miranda, S., et al. (2024). Radiation-induced DNA double-strand breaks in cortisol exposed fibroblasts as quantified with the novel foci-integrated damage complexity score (FIDCS). Scientific Reports, 14(1), Article 10400.
19. Coppes, R. P. (2024). Single-cell transcriptomics on salivary gland organoids after photon and proton radiotherapy. Radiotherapy and Oncology, 194, S105–S106.
20. van Rijn-Dekker, M. I., la Bastide-van Gemert, S., & Stokman, M. A., et al. (2024). Radiation-induced xerostomia is related to stem cell dose-dependent reduction of saliva production. Radiotherapy and Oncology, 194, S1184–S1186.

Profile Details
https://research.rug.nl/en/persons/rob-coppes/
https://www.researchgate.net/profile/Robert-Coppes

WOS ResearcherID: B-4089-2008