Prof. Jong Eun Lee

Yonsei University, South Korea

Email: [email protected]

Qualifications

1993 Ph.D., Biochemistry, Neurochemistry, Yonsei University, Korea

1985 M.S., Biochemistry, Protein Biochemistry, Yonsei University, Korea

1983 B.S., Biochemistry, Yonsei University, Korea

Publications (Selected)

1. Chang, J. Y., Kim, J., Kim, J. Y., et al. (2025). The Role of Agmatine in Modulating Autophagy Under Neuroinflammatory Conditions Induced by Metabolic Alteration in Mouse Brain. Experimental Neurobiology, 34(3), 95–107.
2. Sim, Y., Kim, J. Y., Lee, Y. H., et al. (2025). Neuroprotective roles of SGLT2 and DPP4 inhibitors: Modulating ketone metabolism and suppressing NLRP3 inflammasome in T2D induced Alzheimer's disease. Experimental Neurology, 390, Article 115271.
3. Kim, H. W., Kim, J., Kim, J. Y., et al. (2025). Transparent, metal-free PEDOT:PSS neural interfaces for simultaneous recording of low-noise electrophysiology and artifact-free two-photon imaging. Nature Communications, 16(1), Article 4032.
4. Lee, J. E., Byeon, K., Kim, S., et al. (2025). Revealing the Multivariate Associations Between Autistic Traits and Principal Functional Connectome. Neuroinformatics, 23(2), Article 27.
5. Lee, J. E., Kim, S., Park, S., et al. (2025). Atypical maturation of the functional connectome hierarchy in autism. Molecular Autism, 16(1), Article 21.
6. Kim, J., Kim, J. Y., & Lee, J. E. (2025). Modulation of cytotoxic T cells by Poly-Glu/Tyr attenuates neuroinflammation after ischemic stroke. Stroke, 56(Suppl 1), TP399.
7. Cho, T. H., Kim, M., Kim, S. H., et al. (2024). Reconsidering Neurogenetic Indication in the Human Brain: Broad Expression of Doublecortin Transcript in the Hippocampal and Cortical Cell Populations. Cells Tissues Organs, 213(5), 382–389.
8. Goh, A. R., Park, J., Sim, A. Y., et al. (2024). Modulating monocyte-derived macrophage polarization in cerebral ischemic injury with hyperglycemia. Experimental Neurology, 378, Article 114824.
9. Lee, S., Kim, J., You, J. S., et al. (2024). Ischemic stroke outcome after promoting CD4+CD25+Treg cell migration through CCR4 overexpression in a tMCAO animal model. Scientific Reports, 14(1), Article 10201.
10. Cho, Y. U., Kim, K., Dutta, A., et al. (2024). MRI-Compatible, Transparent PEDOT:PSS Neural Implants for the Alleviation of Neuropathic Pain with Motor Cortex Stimulation. Advanced Functional Materials, 34(6).
11. Sim, A. Y., Choi, D. H., Kim, J. Y., et al. (2023). SGLT2 and DPP4 inhibitors improve Alzheimer's disease-like pathology and cognitive function through distinct mechanisms in a T2D-AD mouse model. Biomedicine & Pharmacotherapy, 168, Article 115755.
12. Choi, Y. S., Song, J. E., Kim, E., et al. (2023). Hyperpolarized [1-13C]pyruvate Magnetic Resonance Spectroscopy Shows That Agmatine Increased Lactate Production in the Brain of Type 2 Diabetic Mice. Yonsei Medical Journal, 64(10), 625–632.
13. Hong, S., Lee, J. E., Kim, C. Y., et al. (2023). RETRACTION: Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line (Retraction of Vol 8, art no 81, 2007). BMC Neuroscience, 24(1), Article 42.
14. Kim, J., Sim, A. Y., Barua, S., et al. (2023). Agmatine-IRF2BP2 interaction induces M2 phenotype of microglia by increasing IRF2-KLF4 signaling. Inflammation Research, 72.
15. Kosonen, R., Chang, J. Y., Lee, S., et al. (2023). APP96-110 Elicits Neuroprotective Effects Following Ischemic Insult in Animal Models. Neurochemical Research, 48(8), 2568–2579.
16. Park, Y. M., Kim, J. H., & Lee, J. E. (2022). Neural Stem Cells Overexpressing Arginine Decarboxylase Improve Functional Recovery from Spinal Cord Injury in a Mouse Model. International Journal of Molecular Sciences, 23(24), Article 15784.
17. Kim, J. Y., Kim, J., Huang, M., et al. (2022). CCR4 and CCR5 Involvement in Monocyte-Derived Macrophage Migration in Neuroinflammation. Frontiers in Immunology, 13, Article 876033.
18. Sim, A. Y., Barua, S., Kim, J. Y., et al. (2021). Role of DPP-4 and SGLT2 Inhibitors Connected to Alzheimer Disease in Type 2 Diabetes Mellitus. Frontiers in Neuroscience, 15, Article 708547.
19. Barua, S., Sim, A. Y., Kim, J. Y., et al. (2021). Maintenance of the Neuroprotective Function of the Amino Group Blocked Fluorescence-Agmatine. Neurochemical Research, 46(8), 1933–1940.
20. Kim, J. Y., Kim, J. H., Park, J., et al. (2022). Targeted Temperature Management at 36 °C Shows Therapeutic Effectiveness via Alteration of Microglial Activation and Polarization After Ischemic Stroke. Translational Stroke Research, 13(1), 132–141.

Profile Details
https://yonsei.elsevierpure.com/en/persons/jongeun-lee/
https://www.researchgate.net/profile/Jong-Eun-Lee-3
https://loop.frontiersin.org/people/184858/overview

WOS ResearcherID: PCD-5251-2025