Prof Jean-François Beaulieu

Université de Sherbrooke, Canada

Email: [email protected]

Qualifications

1985 Ph.D., Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Canada

1982 M.Sc., Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Canada

1979 B.Sc., Biology (Biochemistry/Physiology), Faculty of Sciences, Université de Sherbrooke, Canada

Publications (Selected)

1. Shajari, E., Gagne, D., Malick, M., et al. (2026). Non-invasive assessment of inflammatory bowel disease activity using a DIA-derived stool peptidomic signature and machine learning. Frontiers in Molecular Biosciences, 13, Article 1768474.
2. Gagne, D., Shajari, E., Malick, M., et al. (2026). Exploring an Intermediate Colorectal Cancer Screening Test Based on Stool Proteomics and Machine Learning for Optimizing the Selection of Patients for Colonoscopy Identified From FIT. Molecular & Cellular Proteomics, 25(4), Article 101534.
3. Garneau, H., Alvarez, L., Paquin, M.-C., et al. (2026). Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells. American Journal of Physiology-Gastrointestinal and Liver Physiology, 330(3), G314.
4. Shajari, E., Gagne, D., Bourassa, F., et al. (2025). Stool-Based Proteomic Signature for the Noninvasive Classification of Crohn's Disease and Ulcerative Colitis Using Machine Learning. Clinical and Translational Gastroenterology, 16(11), Article e00925.
5. Cloutier, G., Khalfaoui, T., Carrier, J. C., et al. (2025). Expression of the RPSA-Containing and 67EBP Laminin Receptors in Relation to the Debatable Nature of the 67 kDa Laminin Receptor 67LR in Colorectal Cancer. International Journal of Molecular Sciences, 26(6), Article 2564.
6. Vahkal, B., Altosaar, I., Ariana, A., et al. (2025). Human milk extracellular vesicles modulate inflammation and cell survival in intestinal and immune cells. Pediatric Research, 98(1), Article s41390-024-03757-5.
7. Cloutier, G., & Beaulieu, J.-F. (2024). Reconsideration of the laminin receptor 67LR in colorectal cancer cells. Biomolecules and Biomedicine, 24(5), 1117–1132.
8. Shajari, E., Gagne, D., Malick, M., et al. (2024). Application of SWATH Mass Spectrometry and Machine Learning in the Diagnosis of Inflammatory Bowel Disease Based on the Stool Proteome. Biomedicines, 12(2), Article 333.
9. Auclair, N., Sane, A. T., Ahmarani, L., et al. (2023). High-fat diet reveals the impact of Sar1b defects on lipid and lipoprotein profile and cholesterol metabolism. Journal of Lipid Research, 64(9), Article 100423.
10. Mancuso, C., Tremblay, E., Gnodi, E., et al. (2023). The Combination of Gold and Silver Food Nanoparticles with Gluten Peptides Alters the Autophagic Pathway in Intestinal Crypt-like Cells. International Journal of Molecular Sciences, 24(17), Article 13040.
11. Cloutier, G., Seltana, A., Fallah, S., et al. (2023). Integrin a7131 represses intestinal absorptive cell differentiation. Experimental Cell Research, 430(2), Article 113723.
12. Yara, S., Lavoie, J.-C., Beaulieu, J.-F., et al. (2023). Editorial Note: Iron-Ascorbate-Mediated Lipid Peroxidation Causes Epigenetic Changes in the Antioxidant Defense in Intestinal Epithelial Cells: Impact on Inflammation. Plos One, 18(7), Article e0289575.
13. Senicourt, B., Cloutier, G., Basora, N., et al. (2023). Primary Cilium Identifies a Quiescent Cell Population in the Human Intestinal Crypt. Cells, 12(7), Article 1059.
14. Gagne, D., Shajari, E., Thibault, M.-P., et al. (2022). Proteomics Profiling of Stool Samples from Preterm Neonates with SWATH/DIA Mass Spectrometry for Predicting Necrotizing Enterocolitis. International Journal of Molecular Sciences, 23(19), Article 11601.
15. Seltana, A., Cloutier, G., Reyes Nicolas, V., et al. (2022). Fibrin(ogen) Is Constitutively Expressed by Differentiated Intestinal Epithelial Cells and Mediates Wound Healing. Frontiers in Immunology, 13, Article 916187.
16. Fallah, S., & Beaulieu, J.-F. (2023). Differential influence of YAP1 and TAZ on differentiation of intestinal epithelial cell: A review. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology, 306(5), 1054–1061.
17. Taha, R., Seidman, E., Mailhot, G., et al. (2022). RETRACTION: Oxidative Stress and Mitochondrial Functions in the Intestinal Caco-2/15 Cell Line (Retraction of Vol 5, art no E11817, 2010). Plos One, 17(4), Article e0267058.
18. Yara, S., Lavoie, J.-C., Beaulieu, J.-F., et al. (2022). Iron-Ascorbate-Mediated Lipid Peroxidation Causes Epigenetic Changes in the Antioxidant Defense in Intestinal Epithelial Cells: Impact on Inflammation (vol 8, e63456, 2013) (Expression of Concern of Vol 8, art no E63456, 2013). Plos One, 17(4), Article e0267237.
19. Fallah, S., & Beaulieu, J.-F. (2021). Src family kinases inhibit differentiation of intestinal epithelial cells through the Hippo effector YAP1. Biology Open, 10(11), Article bio058904.
20. Thibault, M.-P., Tremblay, E., Horth, C., et al. (2022). Lipocalin-2 and calprotectin as stool biomarkers for predicting necrotizing enterocolitis in premature neonates. Pediatric Research, 91(1), 129–136.
21. Mancuso, C., Re, F., Rivolta, I., et al. (2021). Dietary Nanoparticles Interact with Gluten Peptides and Alter the Intestinal Homeostasis Increasing the Risk of Celiac Disease. International Journal of Molecular Sciences, 22(11), Article 6102.
22. Vahkal, B., Kraft, J., Ferretti, E., et al. (2021). Review of Methodological Approaches to Human Milk Small Extracellular Vesicle Proteomics. Biomolecules, 11(6), Article 833.

Profile Details
https://www.usherbrooke.ca/recherche/fr/specialistes/details/jean-francois.beaulieu
https://scholar.google.com/citations?user=YNDL3G8AAAAJ&hl=en
https://www.researchgate.net/profile/Jean-Francois-Beaulieu

WOS ResearcherID: D-2054-2010