Dr. Umberto Galderisi

University of Campania "Luigi Vanvitelli", Italy

Email: [email protected]

Qualifications

1992 Ph.D., Dept. of Genetics, University “Federico II”, Italy

1987 B.Sc., Biology, University “Federico II”, Italy

Publications (Selected)

1. Acar, M. B., Ayaz-Güner, S., Gunaydin, Z., et al. (2021). Proteomic and biological analysis of the effects of metformin senomorphics on the mesenchymal stromal cells. Frontiers in Bioengineering and Biotechnology, 9, Article 730813.
2. Alessio, N., Acar, M. B., Squillaro, T., et al. (2023). Progression of irradiated mesenchymal stromal cells from early to late senescence: Changes in SASP composition and anti-tumour properties. Cell Proliferation, 56(6), Article e13401.
3. Alessio, N., Aprile, D., Peluso, G., et al. (2024). IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptors. Cell Communication and Signaling, 22(1), Article 122.
4. Alessio, N., Stellavato, A., Aprile, D., et al. (2021). Timely supplementation of hydrogels containing sulfated or unsulfated chondroitin and hyaluronic acid affects mesenchymal stromal cells commitment toward chondrogenic differentiation. Frontiers in Cell and Developmental Biology, 9, Article 641529.
5. Aprile, D., Alessio, N., Squillaro, T., et al. (2023). Role of glycosphingolipid SSEA-3 and FGF2 in the stemness and lineage commitment of multilineage differentiating stress enduring (MUSE) cells. Cell Proliferation, 56(1), Article e13345.
6. Aprile, D., Patrone, D., Al Sammarraie, S. H. A., et al. (2026). Lineage specification into GABAergic, glutamatergic, dopaminergic, and astrocytic phenotypes using MUSE stem cells: A novel approach for modeling neurodegenerative and psychiatric disorders. Molecular Psychiatry, 31(3), 1372–1384.
7. Aprile, D., Patrone, D., Peluso, G., et al. (2024). Multipotent/pluripotent stem cell populations in stromal tissues and peripheral blood: Exploring diversity, potential, and therapeutic applications. Stem Cell Research & Therapy, 15(1), Article 139.
8. Di Tomo, P., Alessio, N., Falone, S., et al. (2021). Endothelial cells from umbilical cord of women affected by gestational diabetes: A suitable in vitro model to study mechanisms of early vascular senescence in diabetes. The FASEB Journal, 35(6), Article e21662.
9. Di Tomo, P., Alessio, N., Falone, S., et al. (2026). Endothelial cells from umbilical cord of women affected by gestational diabetes: A suitable in vitro model to study mechanisms of early vascular senescence in diabetes (vol 32, e21662, 2021). The FASEB Journal, 40(4), Article e71560.
10. Galderisi, U., Peluso, G., & Di Bernardo, G. (2022). Clinical trials based on mesenchymal stromal cells are exponentially increasing: Where are we in recent years? Stem Cell Reviews and Reports, 18(1), 23–36.
11. Mattei, V., Santilli, F., Pulcini, F., et al. (2025). Validated methods for isolation and qualification of mesenchymal stromal/stem cells from different sources. Journal of Translational Medicine, 23(1), Article 975.
12. Mazzone, V., Alessio, N., Aprile, D., et al. (2025). Terpenes: Natural compounds found in plants as potential senotherapeutics targeting senescent mesenchymal stromal cells and promoting apoptosis. Stem Cell Research & Therapy, 16(1), Article 231.
13. Mosca, N., Alessio, N., Di Paola, A., et al. (2024). Osteosarcoma in a ceRNET perspective. Journal of Biomedical Science, 31(1), Article 59.
14. Najahi, H., Alessio, N., Squillaro, T., et al. (2022). Environmental microplastics (EMPs) exposure alter the differentiation potential of mesenchymal stromal cells. Environmental Research, 214, Article 114088.
15. Oguma, Y., Alessio, N., Aprile, D., et al. (2023). Meta-analysis of senescent cell secretomes to identify common and specific features of the different senescent phenotypes: A tool for developing new senotherapeutics. Cell Communication and Signaling, 21(1), Article 262.
16. Ragni, E., Elia, N., Galderisi, U., et al. (2026). A comprehensive summary of the Third International StemNet Meeting 2026. Frontiers in Bioscience-Landmark, 31(6), Article 53791.
17. Shahzaib, M., Aprile, D., Alessio, N., et al. (2026). Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity. Free Radical Biology and Medicine, 250, 49–63.
18. Shahzaib, M., Aprile, D., Squillaro, T., et al. (2026). A conserved regulatory architecture stabilizes cellular senescence across distinct triggers in human fibroblasts. GeroScience, 48(3), 3511–3529.
19. Shahzaib, M., Aprile, D., Squillaro, T., et al. (2026). The interactome era: Integrating RNA-seq, proteomics, and network biology to decode cellular senescence. Ageing Research Reviews, 113, Article 102916.
20. Siraj, Y., Aprile, D., Alessio, N., et al. (2024). IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways. Cell Communication and Signaling, 22(1), Article 540.

Profile Details
https://www.medicinasperimentale.unicampania.it/dipartimento/docenti?MATRICOLA=058276
https://www.researchgate.net/profile/Umberto-Galderisi
https://galderisi-lab.webnode.it/umberto-galderisi/

WOS ResearcherID: GAV-7871-2022