Dr. Yigang Wang

Department of Pathology and Laboratory Medicine

Universityof Cincinnati, USA

Email:[email protected]

Qualifications

1997 Ph.D., Tokyo Medical and Dental University, Japan

1983 M.D., Qinghai Medical College, China

Publications (Selected)

1. Ahmad, W., Dutta, S., He, X. Y., et al. (2025). In Vivo Targeted Reprogramming of Cardiac Fibroblasts for Heart Regeneration: Advances and Therapeutic Potential. Bioengineering-Basel, 12(9), Article 940.
2. Alam, P., Maliken, B. D., Jones, S. M., et al. (2021). Cardiac Remodeling and Repair: Recent Approaches, Advancements, and Future Perspective. International Journal of Molecular Sciences, 22(23), Article 13104.
3. Bi, W., Wang, J. X., Jiang, Y., et al. (2021). Neurotrophin-3 contributes to benefits of human embryonic stem cell-derived cardiovascular progenitor cells against reperfused myocardial infarction. Stem Cells Translational Medicine, 10(5), 756-772.
4. Cai, W. F., Jiang, L., Liang, J. L., et al. (2024). HAX1-Overexpression Augments Cardioprotective Efficacy of Stem Cell-Based Therapy Through Mediating Hippo-Yap Signaling. Stem Cell Reviews and Reports, 20(6), 1569-1586.
5. Du, W., Khandakar, G. I., Zhang, Y. T., et al. (2025). Role of Endothelial Reelin in diabetic cardiomyopathy and chronic inflammation. Circulation Research, 137(Suppl_1), Article Thu112.
6. Dutta, S., Chen, S. P., Ahmad, W., et al. (2026a). In vivo CRISPR-mediated activation of cardiogenic genes to reprogram cardiac fibroblasts. Frontiers in Cell and Developmental Biology, 14, Article 1812941.
7. Dutta, S., Chen, S. P., Ahmad, W., et al. (2026b). Targeting Cardiac Fibroblast Plasticity for Antifibrotic and Regenerative Therapy in Heart Failure. Cells, 15(2), Article 112.
8. Feng, Y. L., Huang, W., Paul, C., et al. (2021). Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases. Basic Research in Cardiology, 116(1), Article 49.
9. Feng, Y. L., Cai, L. Y., Hong, W. Z., et al. (2022). Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy. Circulation, 145(22), 1663-1683.
10. Gong, M., Wang, M., Xu, J., et al. (2022). Nano-Sized Extracellular Vesicles Secreted from GATA-4 Modified Mesenchymal Stem Cells Promote Angiogenesis by Delivering Let-7 miRNAs. Cells, 11(9), Article 1573.
11. He, M. Y., Tay, W. T., Song, N. J., et al. (2025). Cardioprotective role of RBFox1 in myocardial infarction-induced heart failure. Cardiovascular Research, 121(16), 2534-2548.
12. He, X. Y., Liang, J. L., Paul, C., et al. (2022). Advances in Cellular Reprogramming-Based Approaches for Heart Regenerative Repair. Cells, 11(23), Article 3914.
13. He, X. Y., Dutta, S., Liang, J. L., et al. (2024a). Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics. Canadian Journal of Physiology and Pharmacology, 102(1), 1-13.
14. He, X. Y., Good, A., Kalou, W., et al. (2024b). Current Advances and Future Directions of Pluripotent Stem Cells-Derived Engineered Heart Tissue for Treatment of Cardiovascular Diseases. Cells, 13(24), Article 2098.
15. He, X. Y., Dutta, S., Desai, D., et al. (2026). Oxygen-generating Microparticles Enhance Viability and Functionality of Human Pluripotent Stem Cell-derived Cardiomyocytes for Myocardial Infarction Therapy. Stem Cell Reviews and Reports, 22(6), 2846-2862.
16. Jiang, L., Liang, J. L., Huang, W., et al. (2022). CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy. Molecular Therapy, 30(1), 54-74.
17. Krishnan, K. C., Frazier, J., He, X. Y., et al. (2025). Mitochondrial Maladaptation at the Crossroads of Heart Failure: A Tale of Two Phenotypes. Circulation Research, 137(Suppl_1), Article Fri112.
18. Li, Q. Q., Li, Y. T., Huang, W., et al. (2022). Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages. Frontiers in Immunology, 13, Article 930397.
19. Li, Y. T., Deng, S., Wang, X. H., et al. (2021). Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signalling in macrophages. Cardiovascular Research, 117(3), 890-902.
20. Park, K. H., He, X. Y., Jiang, L., et al. (2023). Activation of MG53 Enhances Cell Survival and Engraftment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Injured Hearts. Stem Cell Reviews and Reports, 19(7), 2420-2428.

Profile Details
https://med.uc.edu/depart/pathology/research/faculty-researchers/Index/Pubs/wanyy
https://scholar.google.com/citations?user=7zeiu8YAAAAJ&hl=en

WOS ResearcherID: DTK-6859-2022