Prof. Lian Li

School of Medicine

Emory University, USA

Email: [email protected]

Qualifications

1991 Ph.D., Biochemistry, University of California

1985 M.Sc., Physical Chemistry, Xiamen University

1982 B.Sc., Xiamen University

Publications (Selected)

1. Li, L., Schuchard, M., Palma, A., Pradier, L., & McNamee, M. G. (1990) gFunctional role of the Cys-451 thiol group in the M4 helix of the subunit of Torpedo californicaacetylcholine receptor. Biochemistry, 29:5428-5436.
2. Eterovic, V. A., Li, L. Palma, A., & McNamee, M. G. (1990) Regulation of nicotinic acetylcholine receptor function by adenine nucleotides. Cell. & Molec. Neurobiology, 10: 423-433.
3. Ochoa, E.L.M., Li, L., Plummer, A., & McNamee, M. G. (1990) Direct effects of thymopentin (Arg-Lys-Asp-Val-Tyr) on cholinergic agonist-induced slow inactivation of nicotinic acetylcholine receptor function. Molecular Pharmacology 38: 863-871.
4. Palma, A., Li, L., Chen, X. Pappone, P., and McNamee, M. G. (1991) Effects of pH on acetylcholine receptor function. J. Membrane Biology 120: 67-73.
5. Li, L. & McNamee, M. G. (1992) Modulation of nicotinic acetylcholine receptor channel by pH: A difference in pH sensitivity ofTorpedoand mouse receptors expressed inXenopusoocytes.Cell. & Molec. Neurobiology, 12: 83-93.
6. Li, L., Lee, Y-H., Pappone, P., Palma, A., & McNamee, M. G. (1992) Site-specific mutations of nicotinic acetylcholine receptor at the lipid-protein interface dramatically alter ion channel gating. Biophys. J. 62: 61-63.
7. Ochoa, E.L.M., Li, L., & McNamee, M. G. (1992)  Neuroadaptation tonicotine: possible role of desensitization of central cholinergic mechanisms in the development of tolerance, dependence and withdrawal. Molecular Neurobiology,4: 251-287
8. Eterovic, V. A., Li, L. Ferchmin, P. A., Lee, Y. H., Hann, R. M., & McNamee, M. G. (1993) The ion channel of muscle and electric organ acetylcholine receptors: differing affinities for noncompetitive inhibitors.Cell. & Molec. Neurobiology, 13: 111-121.
9. Eterovic, V. A., Hann, R. M., Ferchmin, P. A., Rodriguez, A. D., Li, L. Lee, Y. H., & McNamee, M. G. (1993) Diterpenoids from Caribbean gorgonians act as  noncompetitive inhibitors of the nicotinic acetylcholine receptor. Cell. & Molec. Neurobiology, 13: 99-110.
10. Li, L., Suzuki, T., Mori, N., & Greengard, P. (1993) Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene. Proc. Natl. Acad. Sci. USA 90: 1460-1464.
11. Lee, Y-H., Li, L., Lasalde, J., Rojas, L., McNamee, M. G., Ortiz-Miranda, S., & Pappone, P. (1994) Mutations in the M4 domain at the lipid-protein interface of  Torpedo californicaacetylcholine receptor dramatically alter ion channel Function. Biophys. J. 66: 646-653.
12. Chin, L.-S., Li, L., & Greengard, P. (1994) Neuron-specific expression of the synapsin II gene is directed by a specific core promoter and upstream regulatory elements. J. Biol. Chem.269: 18507-18513.
13. Li, L., Chin, L-S., Shupliakow, O., Brodin L., Sihra, T., Hvalby, O., Jensen, V., Zheng, D., McNamara, J. O., Greengard, P., &Andersen, P.(1995) Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice. Proc. Natl. Acad. Sci. USA  92: 9235-9239.
14. Chin, L.-S., Li, L., Ferreira, A., Kosik, K. S., & Greengard, P. (1995) Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice. Proc. Natl. Acad. Sci. USA  92: 9230-9234.
15. Li, L., Chin, L. -S., Greengard, P., Copeland, N. G., Gilbert, D. J., & Jenkins, N. A. (1995) Localization of the synapsin II gene to human chromosome 3 and mouse chromosome 6. Genomics  28: 365-366.
16. Ferreira, A., Li, L., Chin, L.-S., Greengard, P., & Kosik, K. S. (1996) Aretarded competence of the postsynaptic element is responsible for the delay in synaptogenesis observed in synapsin I-deficient neurons. Molec. & Cell. Neurosci. 8: 286-299.
17. Ryan, T. A., Li, L., Chin, L.-S., Greengard, P., & Smith, S. J. (1996). Synaptic vesicle recycling in synapsin I knockout mice. J. Cell Biol. 134:1219-1227.
18. Ferreira, A., Chin, L.-S., Li, L., Lanier, L. M., Kosik, K. S. &Greengard, P.(1998)Distinct roles of synapsin I and synapsin II during neuronal development. Molecular Medicine 4: 22-28.
19. Chin,L-S., Fu, Q., Kachinsky, A. M., Jabren, G., Niu, Y. & Li, L. (1999) Neuron-specific and developmental regulation of the synapsin II gene expression in transgenic mice. Brain Res. Mol. Brain Res. 67: 239-246.
20. Walaas, S. I., Hilfiker, S., Li, L., Chin, L.-S., & Greengard, P. (2000) Decrease in phorbol ester-induced potentiation of noradrenaline release in synapsin I-deficient mice. Synapse 36:114-119.
21. Chin,L-S., Nugent, R. D., Raynor, M. C., Vavalle, J. P. & Li, L. (2000) SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis. J. Biol. Chem. 275: 1191-1200.
22. Kwong, J., Roudabush, F. L., Moore, P. H., Montague, M., Oldham, W., Li, Y., Chin, L-S., & L. Li. (2000) Hrs interacts with SNAP-25 and regulates Ca2+-dependent exocytosis. J. Cell Sci. 113:2273-2284.
23. Chin,L-S., Weigel, C., & Li, L. (2000) Transcriptional regulation of gene expression of Sec6, a component of mammalian exocyst complex at the synapse. Brain Res. Mol. Brain Res.79: 127-137.
24. Li, Y., Chin,L-S., Weigel, C., & Li, L. (2001) Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis. J. Biol. Chem. 276: 40824-40833.
25. Chin,L-S., Raynor, M. C., Wei, X., Chen, H-Q., & Li, L. (2001) Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. J. Biol. Chem. 276: 7069-7078.
26. Li, Y., Chin,L-S., Levey, A. I., & Li, L. (2002) Huntingtin-associated protein 1 interacts with Hrs and functions in endosomal trafficking.J. Biol. Chem. 277: 28212-28221.
27. Ahn, K., Yeyeodu, S., Collette, J., Madden, V., Arthur, J., Li, L., & Erickson, A. H. (2002) An alternate targeting pathway for procathepsin L in mouse fibroblasts. Traffic 3: 147-159.
28. Wheeler, T. C., Chin, L-S., Li, Y., Roudabush, F. L., & Li, L. (2002) Regulation of synaptophysin degradation by mammalian homologues of seven in absentia. J. Biol. Chem. 277: 10273-10282.
29. Chin L-S., Vavalle J. P., & Li, L. (2002) Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation. J. Biol. Chem. 277: 35071-35079.
30. Huai, Q., Sun, Y., Wang, H., Chin L-S., Li, L., Robinson, H. & Ke, H. (2003) Crystal structure of DJ-1/RS and implication on familial Parkinson’s disease. FEBS Lett. 549: 171-175.
31. Choi J, Levey AI, Weintraub ST, et al. Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J Biol Chem. 2004;279(13):13256-13264. doi:10.1074/jbc.M314124200
32. Choi J, Rees HD, Weintraub ST, Levey AI, Chin LS, Li L. Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases. J Biol Chem. 2005;280(12):11648-11655. doi:10.1074/jbc.M414327200
33. Choi J, Sullards MC, Olzmann JA, et al. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J Biol Chem. 2006;281(16):10816-10824. doi:10.1074/jbc.M509079200
34. Olzmann JA, Bordelon JR, Muly EC, et al. Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. J Comp Neurol. 2007;500(3):585-599. doi:10.1002/cne.21191
    Olzmann JA, Li L, Chin LS. Aggresome formation and neurodegenerative diseases: therapeutic implications. Curr Med Chem. 2008;15(1):47-60. doi:10.2174/092986708783330692
35. Pridgeon JW, Webber EA, Sha D, Li L, Chin LS. Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes. FEBS J. 2009;276(1):118-131. doi:10.1111/j.1742-4658.2008.06760.x
36. Sha D, Chin LS, Li L. Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet. 2010;19(2):352-363. doi:10.1093/hmg/ddp501
37. Lee SM, Olzmann JA, Chin LS, Li L. Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways. J Cell Sci. 2011;124(Pt 19):3319-3331. doi:10.1242/jcs.087114
38. Hurst-Kennedy J, Chin LS, Li L. Ubiquitin C-terminal hydrolase l1 in tumorigenesis. Biochem Res Int. 2012;2012:123706. doi:10.1155/2012/123706
39. Lee SM, Sha D, Mohammed AA, et al. Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot-Marie-Tooth disease type 1C. Hum Mol Genet. 2013;22(9):1755-1770. doi:10.1093/hmg/ddt022
40. Fallaize D, Chin LS, Li L. Differential submitochondrial localization of PINK1 as a molecular switch for mediating distinct mitochondrial signaling pathways. Cell Signal. 2015;27(12):2543-2554. doi:10.1016/j.cellsig.2015.09.020
41. Chin LS, Li L. Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatment. Transl Neurodegener. 2016;5:1. Published 2016 Jan 6. doi:10.1186/s40035-015-0049-6
42. Zhang Q, Ma C, Gearing M, Wang PG, Chin LS, Li L. Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer's disease. Acta Neuropathol Commun. 2018;6(1):19. Published 2018 Mar 1. doi:10.1186/s40478-018-0524-2
43. Zlatic SA, Vrailas-Mortimer A, Gokhale A, et al. Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees. Cell Syst. 2018;6(3):368-380.e6. doi:10.1016/j.cels.2018.01.008
44. Lee SM, Asress S, Hales CM, et al. TDP-43 cytoplasmic inclusion formation is disrupted in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal lobar degeneration. Brain Commun. 2019;1(1):fcz014. doi:10.1093/braincomms/fcz014
45. Shimizu Y, Nicholson CK, Polavarapu R, et al. Role of DJ-1 in Modulating Glycative Stress in Heart Failure. J Am Heart Assoc. 2020;9(4):e014691. doi:10.1161/JAHA.119.014691
46. Casin KM, Calvert JW. Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease. Antioxidants (Basel). 2021;10(3):383. Published 2021 Mar 4. doi:10.3390/antiox10030383
47. Casin KM, Calvert JW. Dynamic Regulation of Cysteine Oxidation and Phosphorylation in Myocardial Ischemia-Reperfusion Injury. Cells. 2021;10(9):2388. Published 2021 Sep 11. doi:10.3390/cells10092388
48. Lindsey ML, Brunt KR, Kirk JA, et al. Guidelines for in vivo mouse models of myocardial infarction. Am J Physiol Heart Circ Physiol. 2021;321(6):H1056-H1073. doi:10.1152/ajpheart.00459.2021

Personal Profile