Biography

Dr. Lbachir Ben Mohamed

The Gavin Herbert Eye Institute & Institute for Immunology

University of California Irvine, USA

Associate Professor


Email: [email protected]


Qualifications

1997 Ph.D., Immunology, Pasteur Institute & Paris VII University, France

1990 M.S., Molecular Biology and Biochemistry, Paris VI University, France


Publications (selected)

  1. Prakash, S., Dhanushkodi, N. R., Zayou, L., Ibraim, I. C., Quadiri, A., Coulon, P. G., ... & BenMohamed, L. (2024). Cross-protection induced by highly conserved human B, CD4+, and CD8+ T-cell epitopes-based vaccine against severe infection, disease, and death caused by multiple SARS-CoV-2 variants of concern. Frontiers in Immunology, 15, 1328905.
  2. Coulon, P. G., Prakash, S., Dhanushkodi, N. R., Srivastava, R., Zayou, L., Tifrea, D. F., ... & BenMohamed, L. (2024). High frequencies of alpha common cold coronavirus/SARS-CoV-2 cross-reactive functional CD4+ and CD8+ memory T cells are associated with protection from symptomatic and fatal SARS-CoV-2 infections in unvaccinated COVID-19 patients. Frontiers in Immunology, 15, 1343716.
  3. Zayou, L., Prakash, S., Dhanushkodi, N. R., Quadiri, A., Ibraim, I. C., Singer, M., ... & BenMohamed, L. (2023). A multi-epitope/CXCL11 prime/pull coronavirus mucosal vaccine boosts the frequency and the function of lung-resident memory CD4+ and CD8+ T cells and enhanced protection against COVID-19-like symptoms and death caused by SARS-CoV-2 infection. Journal of Virology, 97(12), e01096-23.
  4. Dhanushkodi, N. R., Prakash, S., Quadiri, A., Zayou, L., Srivastava, R., Tran, J., ... & BenMohamed, L. (2023). Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+ CD44+ CD62L− CD8+ T Cells and Memory CCR10+ B220+ CD27+ B Cells into the Infected Vaginal Mucosa. The Journal of Immunology, 211(1), 118-129.
  5. Planès, R., Bert, J. B., Tairi, S., BenMohamed, L., & Bahraoui, E. (2022). SARS-CoV-2 envelope (E) protein binds and activates TLR2 pathway: a novel molecular target for COVID-19 interventions. Viruses, 14(5), 999.
  6. Chentoufi, A. A., Dhanushkodi, N. R., Srivastava, R., Prakash, S., Coulon, P. G. A., Zayou, L., ... & BenMohamed, L. (2022). Combinatorial herpes simplex vaccine strategies: from bedside to bench and back. Frontiers in Immunology, 13, 849515.
  7. Prakash, S., Srivastava, R., Coulon, P. G., Dhanushkodi, N. R., Chentoufi, A. A., Tifrea, D. F., ... & BenMohamed, L. (2021). Genome-wide B cell, CD4+, and CD8+ T cell epitopes that are highly conserved between human and animal coronaviruses, identified from SARS-CoV-2 as targets for preemptive pan-coronavirus vaccines. The Journal of Immunology, 206(11), 2566-2582.
  8. Coulon, P. G., Dhanushkodi, N., Prakash, S., Srivastava, R., Roy, S., Alomari, N. I., ... & BenMohamed, L. (2019). NLRP3, NLRP12, and IFI16 inflammasomes induction and caspase-1 activation triggered by virulent HSV-1 strains are associated with severe corneal inflammatory herpetic disease. Frontiers in immunology, 10, 1631.
  9. Esteves, P. J., Abrantes, J., Baldauf, H. M., BenMohamed, L., Chen, Y., Christensen, N., ... & Mage, R. (2018). The wide utility of rabbits as models of human diseases. Experimental & molecular medicine, 50(5), 1-10.
  10. Srivastava, R., Khan, A. A., Chilukuri, S., Syed, S. A., Tran, T. T., Furness, J., ... & BenMohamed, L. (2017). CXCL10/CXCR3-dependent mobilization of herpes simplex virus-specific CD8+ TEM and CD8+ TRM cells within infected tissues allows efficient protection against recurrent herpesvirus infection and disease. Journal of virology, 91(14), 10-1128.
  11. Khan, A. A., Srivastava, R., Chentoufi, A. A., Kritzer, E., Chilukuri, S., Garg, S., ... & BenMohamed, L. (2017). Bolstering the number and function of HSV-1–specific CD8+ effector memory T cells and tissue-resident memory T cells in latently infected trigeminal ganglia reduces recurrent ocular herpes infection and disease. The Journal of Immunology, 199(1), 186-203.
  12. Ben Haij, N., Planès, R., Leghmari, K., Serrero, M., Delobel, P., Izopet, J., ... & Bahraoui, E. (2015). HIV-1 Tat protein induces production of proinflammatory cytokines by human dendritic cells and monocytes/macrophages through engagement of TLR4-MD2-CD14 complex and activation of NF-κB pathway. PloS one, 10(6), e0129425.
  13. Yin, Z., Chowdhury, S., McKay, C., Baniel, C., Wright, W. S., Bentley, P., ... & Huang, X. (2015). Significant impact of immunogen design on the diversity of antibodies generated by carbohydrate-based anticancer vaccine. ACS chemical biology, 10(10), 2364-2372.
  14. Zhu X, Ramos TV, Gras-Masse H, Kaplan BE, Ben Mohamed L. Lipopeptide epitopes extended by an Nepsilon-palmitoyl-lysine moiety increase uptake and maturation of dendritic cells through a Toll-like receptor-2 pathway and trigger a Th1-dependent protective immunity.European Journal of Immunology. 2004.4(11):3102-14.
  15. Zhang X, Issagholian A, Berg EA, Fishman JB, Nesburn AB,Ben Mohamed L. Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector CD8+ Tc1 responses and protect against ocular infection.Journal of Virology.2005.79(24):15289-301.
  16. Vichier-Guerre S, Lo-Man R,Ben Mohamed L, Dériaud E, Kovats S, Leclerc C, Bay S. Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide: a potential anti cancer vaccine for human use. Journal of Peptide Research.2003.62(3):117-24.
  17. Perng GC, Maguen B, Jin L, Mott KR, Kurylo J,Ben Mohamed L, Yukht A, Osorio N, Nesburn AB, Henderson G, Inman M, Jones C, Wechsler SL. A novel herpes simplex virus type 1 transcript (AL-RNA) antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits.Journal of Virology.2002.76(16):8003-10.
  18. Peng W, Henderson G, Inman M,Ben Mohamed L, Perng GC, Wechsler SL, Jones C. The locus encompassing the latency-associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal Ganglia of acutely infected mice.Journal of Virology.2005.79(10):6162-71.
  19. Nesburn AB, Ramos TV, Zhu X, Asgarzadeh H, Nguyen V,Ben Mohamed L. Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant.Vaccine.2005.23(7):873-83.
  20. Nesburn AB, Bettahi I, Zhang X, Zhu X, Chamberlain W, Afifi RE, Wechsler SL,Ben Mohamed L. Topical/mucosal delivery of sub-unit vaccines that stimulate the ocular mucosal immune system.Ocular Surface.2006.4(4):178-87.
  21. Nesburn AB, Bettahi I, Dasgupta G, Chentoufi AA, Zhang X, You S, Morishige N, Wahlert AJ, Brown DJ, Jester JV, Wechsler SL,Ben Mohamed L. Functional Foxp3+ CD4+ CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection.Journal of Virology.2007.81(14):7647-61.
  22. Lo-Man R, Vichier-Guerre S, Perraut R, Dériaud E, Huteau V,Ben Mohamed L, Diop OM, Livingston PO, Bay S, Leclerc C. A fully synthetic therapeutic vaccine candidate targeting carcinoma-associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates.Cancer Research.2004.64(14):4987-94.
  23. Daubersies P, Thomas AW, Millet P, Brahimi K, Langermans JA, Ollomo B,Ben Mohamed L, Slierendregt B, Eling W, Van Belkum A, Dubreuil G, Meis JF, Guérin-Marchand C, Cayphas S, Cohen J, Gras-Masse H, Druilhe P. Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3. Nature Medicine.2000.6(11):1258-63.
  24. Brahimi K, Badell E, Sauzet JP,Ben Mohamed L, Daubersies P, Guérin-Marchand C, Snounou G, Druilhe P. Human antibodies against Plasmodium falciparum liver-stage antigen 3 cross-react with Plasmodium yoelii preerythrocytic-stage epitopes and inhibit sporozoite invasion in vitro and in vivo.Infection and Immunity.2001.69(6):3845-52.
  25. Bossus M,Ben Mohamed L, Londono A, Barbier B, Tartar A, Druilhe P, Gras-Masse H. Improved detection of human antibodies to a Plasmodium antigen using a peptide modified with Aib residues.Journal of Peptide Science.1997. Jan-Feb;3(1):47-53.
  26. Bettahi I, Zhang X, Afifi RE,Ben Mohamed L. Protective immunity to genital herpes simplex virus type 1 and type 2 provided by self-adjuvanting lipopeptides that drive dendritic cell maturation and elicit a polarized Th1 immune response. Viral Immunology.2006.19(2):220-36.
  27. Ben Mohamed L, Wechsler SL, Nesburn AB. Lipopeptide vaccines--yesterday, today, and tomorrow. Lancet Infectious Diseases.2002.2(7):425-31.
  28. Ben Mohamed L, Thomas A, Druilhe P. Long-term multiepitopic cytotoxic-T-lymphocyte responses induced in chimpanzees by combinations of Plasmodium falciparum liver-stage peptides and lipopeptides.Infection and Immunity.2004. 72(8):4376-84.
  29. Ben Mohamed L, Thomas A, Bossus M, Brahimi K, Wubben J, Gras-Masse H, Druilhe P. High immunogenicity in chimpanzees of peptides and lipopeptides derived from four new Plasmodium falciparum pre-erythrocytic molecules.Vaccine.2000.18(25):2843-55.
  30. Ben Mohamed L, Krishnan R, Longmate J, Auge C, Low L, Primus J, Diamond DJ. Induction of CTL response by a minimal epitope vaccine in HLA A*0201/DR1 transgenic mice: dependence on HLA class II restricted T(H) response.Human Immunology.2000.61(8):764-79.
  31. Ben Mohamed L, Krishnan R, Auge C, Primus JF, Diamond DJ. Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses. Immunology.2002.106(1):113-21.
  32. Ben Mohamed L, Bertrand G, McNamara CD, Gras-Masse H, Hammer J, Wechsler SL, Nesburn AB. Identification of novel immunodominant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus glycoprotein D that confer protective immunity.Journal of Virology.2003.77(17):9463-73.
  33. Ben Mohamed L, Belkaid Y, Loing E, Brahimi K, Gras-Masse H, Druilhe P. Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant. European Journal of Immunology. 2002.32(8):2274-81.


Profile Details

https://ophthalmology.uci.edu/about/faculty/lbenmoha
https://scholar.google.com/citations?user=Z6Od5jEAAAAJ&hl=en
https://www.researchgate.net/profile/Lbachir-Benmohamed
https://loop.frontiersin.org/people/593967/overview

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