Professor

Email:[email protected]

Qualifications

1986 B.S., Michigan State University

Publications (Selected)

1. Xu, T., Su, T., Soye, B. J. D., Kandi, S., Huang, C. F., Wilkins, J. T., ... & Kelleher, N. L. (2025). The Proteoform Landscape of Tau from the Human Brain. Journal of Proteome Research, 24(6), 2916-2925.
2. Pottier, C., Küçükali, F., Baker, M., Batzler, A., Jenkins, G. D., van Blitterswijk, M., ... & Rademakers, R. (2025). Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing. Nature communications, 16(1), 3914.
3. Cheng, F., Feng, Y., Yang, X., Flanagan, M., Chen, X., Bonakdarpour, B., ... & Cummings, J. (2025). Genomic and epigenomic insights into purkinje and granule neurons in Alzheimer’s disease and related dementia using single-nucleus multiome analysis. Research Square, rs-3.
4. van Olst, L., Simonton, B., Edwards, A. J., Forsyth, A. V., Boles, J., Jamshidi, P., ... & Gate, D. (2025). Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease. Nature Medicine, 1-13.
5. Tiek, D., Song, X., Yu, X., Wu, R., Iglesia, R., Catezone, A., ... & Cheng, S. Y. (2025). Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma. iScience, 28(2).
6. Fortington, L. V., Cassidy, J. D., Castellani, R. J., Gardner, A. J., McIntosh, A. S., Austen, M., ... & Quarrie, K. L. (2025). Epidemiological principles in claims of causality: An enquiry into repetitive head impacts (RHI) and chronic traumatic encephalopathy (CTE). Sports Medicine, 55(2), 255-274.
7. Castellani, R. J., Jamshidi, P., Plascencia-Villa, G., & Perry, G. (2024). The Amyloid Cascade Hypothesis: A Conclusion in Search of Support. The American Journal of Pathology.
8. Sridharan, P. S., Koh, Y., Miller, E., Hu, D., Chakraborty, S., Tripathi, S. J., ... & Pieper, A. A. (2024). Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury. Cell Reports Medicine, 5(9).
9. Cheng, F., Feng, Y., Flanagan, M., Bonakdarpour, B., Jamshidi, P., Castellani, R., ... & Cummings, J. (2024). Single-nucleus multiome analysis of human cerebellum in Alzheimer’s disease-related dementia. Research Square, rs-3.
10. Chia, R., Ray, A., Shah, Z., Ding, J., Ruffo, P., Fujita, M., ... & Scholz, S. W. (2024). Genome sequence analyses identify novel risk loci for multiple system atrophy. Neuron, 112(13), 2142-2156.
11. Valentino, R. R., Scotton, W. J., Roemer, S. F., Lashley, T., Heckman, M. G., Shoai, M., ... & Riehl, J. (2024). MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study. The Lancet Neurology, 23(5), 487-499.
12. Turner, M., Belli, A., & Castellani, R. J. (2024). Changes in brain structure and function in a multisport cohort of retired female and male athletes, many years after suffering a concussion: implications for neuroplasticity and neurodegenerative disease pathogenesis. Journal of Alzheimer's disease reports, 8(1), 501-516.
13. Høilund-Carlsen, P. F., Alavi, A., Barrio, J. R., Castellani, R. J., Costa, T., Herrup, K., ... & Vissel, B. (2024). Revision of Alzheimer’s diagnostic criteria or relocation of the Potemkin village. Ageing Research Reviews, 93, 102173.
14. Minogue, G., Kawles, A., Zouridakis, A., Keszycki, R., Macomber, A., Lubbat, V., ... & Gefen, T. (2023). Distinct Patterns of Hippocampal Pathology in Alzheimer's Disease with Transactive Response DNA‐binding Protein 43. Annals of neurology, 94(6), 1036-1047.
15. Perez Giraldo, G. S., Singer, L., Cao, T., Jamshidi, P., Dixit, K., Kontzialis, M., ... & Graham, E. L. (2023). Differential diagnosis of tumor-like brain lesions. Neurology: Clinical Practice, 13(5), e200182.
16. Iverson, G. L., Kissinger-Knox, A., Huebschmann, N. A., Castellani, R. J., & Gardner, A. J. (2023). A narrative review of psychiatric features of traumatic encephalopathy syndrome as conceptualized in the 20th century. Frontiers in Neurology, 14, 1214814.

Profile Details

WoS ResearcherID: A-9555-2009

https://orcid.org/0000-0002-5414-3184

https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=53137

https://scholar.google.com/citations?user=ZgisTXIAAAAJ&hl=en

https://www.researchgate.net/profile/Rudolph-Castellani