Prof. Xianxin
Hua
University of
Pennsylvania, USA
Professor of Cancer Biology
Email:
[email protected]
Qualifications
1995 Ph.D.,
University of Texas Southwestern Medical Center, USA
1986 M.S.,
Hubei Medical College, China
1983 M.D.,
Hubei Medical College, China
Publications (Selected)
-
Zijie Feng, Xin He, Xuyao Zhang, Yuan Wu, Bowen Xing, Alison Knowles, Qiaonan Shan, Samuel Miller, Taylor Hojnacki, Jian Ma, Bryson W. Katona, Terence P. F. Gade, Jörg Schrader, David C. Metz, Carl H. June & Xianxin Hua: Potent suppression of neuroendocrine tumors and gastrointestinal cancers by CDH17CAR T cells without toxicity to normal tissues. Nature Cancer March 2022.
-
Jian Ma1, Bowen Xing, Yan Cao, Xin He , Kate E Bennett, Chao Tong,Chiying An, Taylor Hojnacki, Zijie Feng, Sunbin Deng, Sunbin Ling, Gengchen Xie, Yuan Wu, Yue Ren, Ming Yu, Bryson W Katona, Hongzhe Li, Ali Naji, Xianxin Hua.: Menin-regulated Pbk controls High fat diet-induced compensatory beta cell proliferation. Embo Molecular Medicine 13(5), May 2021.
-
Xin He, Zijie Feng, Jian Ma, Yan Cao, Sunbin Ling, Xuyao Zhang, Bowen Xing, Bryson W Katona, Carl H June, Xianxin Hua.: CAR T cells targeting CD13 controllably induce eradication of acute myeloid leukemia with a single domain antibody-switch. Leukemia March 2021.
-
Ma J, He X, Cao Y, O’Dwyer K, Szigety KM, Wu Y, Gurung B, Feng Z, Katona BW, Hua X: Islet-specific Prmt5 excision leads to reduced insulin expression and glucose intolerance in mice. J. Endocrinol. 244(1): 41-52, Jan 2020.
-
He X, Feng Z, Ma J, Ling S, Cao Y, Gurung B, Wu Y, Katona BW, O'Dwyer KP, Siegel DL, June CH, Hua X. : Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia. Blood 135(10): 713-723, March 2020.
-
Katona BW, Glynn RA, Paulosky KE, Feng Z, Davis CI, Ma J, Berry CT, Szigety KM, Matkar S, Liu Y, Wang H, Wu Y, He X, Freedman BD, Brady DC, Hua X: Combined Menin and EGFR Inhibitors Synergize to Suppress Colorectal Cancer via EGFR-Independent and Calcium-Mediated Repression of SKP2 Transcription. Cancer Research 79(9): 2195-2207, May 2019.
-
Wu Y, Doepner M, Hojnacki T, Feng Z, Katona BW, He X, Ma J, Cao Y, Busino L, Zhou F, Hua X: Disruption of the menin-MLL interaction triggers menin protein degradation via ubiquitin-proteasome pathway. Am. J. Cancer Res 9(8): 1682-1694, August 2019.
-
Zijie Feng, Lei Wang, Yanmei Sun, Zongzhe Jiang, Bowen Xing, John Domsic, Jingjing Tian, David C. Metz, Xiaolu Yang, Ronen Marmostein, Xiaosong Ma and Xianxin Hua: Menin and Daxx Interact to Control Pancreatic Neuroendocrine Tumors via Epigenetic Regulation of Membrane Metallo-Endopeptidase. Cancer Research 77(2): 401-411, Jan 2017.
-
Matkar S, Sharma P, Gao S, Gurung B, Katona BW, Liao J, Muhammad AB, Kong XC, Wang L, Jin G, Dang CV, Hua X: An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis. Cancer Cell 28(4): 472-85, Oct 2015.
-
Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, Barsyte-Lovejoy D, Al-awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL: Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature 525(7568): 206-11, Sep 2015.
-
Jing Huang, Buddha Gurung, Bingbing Wan, Smita Matkar, Natalia A. Veniaminova, Ke Wan, Juanita L. Merchant, Xianxin Hua*, and Ming Lei* (*co-corresponding author): The same pocket in menin binds both MLL and JunD, but oppositely regulates transcription. Nature 432(7386): 542-6, Feb 2012.
-
Thiel, A.T., Blessington, P., Zou, T., Feather, D, Wu, X., Zhang, H., Liu, L., Koretzky, G., Ernst, P., and Hua, X: MLL-AF9-induced leukemic transformation requires co-expression of wild type MLL allele. Cancer Cell 17(2): 148-159, Feb 2010 Notes: The work was featured on the cover of this issue of Cancer Cell.
Profile Details
https://orcid.org/0000-0003-4862-4691
https://www.med.upenn.edu/apps/faculty/index.php/g275/p10254
https://www.researchgate.net/profile/Xianxin-Hua
https://www.harringtondiscovery.org/scholars/xianxin-hua