Prof. Rolf König

Department of Microbiology & Immunology

The University of Texas Medical Branch, USA

Email: [email protected]

Qualifications

1984 Ph.D., Biology, University of Bern, Switzerland

1980 M.S., Biology, University of Bern, Switzerland

1978 B.S., Zoology with Physics, Chemistry, and Biochemistry as minor subjects, University of Bern, Switzerland

Publications (selected)

1. Lin, C., Kuffour, E. O., Fuchs, N. V., Gertzen, C. G. W., Kaiser, J., Hirschenberger, M., Tang, X., Xu, H. C., Michel, O., Tao, R., Haase, A., Martin, U., Kurz, T., Drexler, I., Görg, B., Lang, P. A., Luedde, T., Sparrer, K. M. J., Gohlke, H., König, R., … Münk, C. (2023). Regulation of STING activity in DNA sensing by ISG15 modification. Cell reports, 42(11), 113277. https://doi.org/10.1016/j.celrep.2023.113277
2. Tschopp, R., König, R. S., Rejmer, P., & Paris, D. H. (2023). Health system support among patients with ME/CFS in Switzerland. Journal of Taibah University Medical Sciences, 18(4), 876-885.
3. König, R. S., Albrich, W. C., Kahlert, C. R., Bahr, L. S., Löber, U., Vernazza, P., Scheibenbogen, C., & Forslund, S. K. (2022). The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS). Frontiers in immunology, 12, 628741. https://doi.org/10.3389/fimmu.2021.628741
4. Sommerfeld, O., Medyukhina, A., Neugebauer, S., Ghait, M., Ulferts, S., Lupp, A., ... & Press, A. T. (2021). Targeting complement C5a receptor 1 for the treatment of immunosuppression in sepsis. Molecular Therapy, 29(1), 338-346.
5. König, R., Kolte, A., Ahlers, O., Oswald, M., Krauss, V., Roell, D., ... & Bauer, M. (2021). Use of IFNγ/IL10 ratio for stratification of hydrocortisone therapy in patients with septic shock. Frontiers in immunology, 12, 607217.
6. Yin, X., Langer, S., Zhang, Z., Herbert, K. M., Yoh, S., König, R., & Chanda, S. K. (2020). Sensor sensibility—HIV-1 and the innate immune response. Cells, 9(1), 254.
7. Eisel, D., Das, K., Dickes, E., König, R., Osen, W., & Eichmüller, S. B. (2019). Cognate interaction with CD4+ T cells instructs tumor-associated macrophages to acquire M1-like phenotype. Frontiers in immunology, 10, 219.
8. Majer, C., Schüssler, J. M., & König, R. (2019). Intertwined: SAMHD1 cellular functions, restriction, and viral evasion strategies. Medical microbiology and immunology, 208, 513-529.
9. Crauwels, P., Bank, E., Walber, B., Wenzel, U. A., Agerberth, B., Chanyalew, M., ... & van Zandbergen, G. (2019). Cathelicidin contributes to the restriction of Leishmania in human host macrophages. Frontiers in immunology, 10, 2697.
10. X. Shen, K. Lee, and R. König (2001) Effects of heavy metal ions on resting and antigen-activated CD4+ T cells. Toxicology 169: 67-80.
11. X. Shen, B. Hu, P. McPhie, X. H. Wu, A. Fox, R. N. Germain, and R. König (1996) Peptides corresponding to CD4-interacting regions of murine MHC class II molecules modulate immune responses of CD4+ T lymphocytesin vitroandin vivo. J. Immunol. 157: 87-100.
12. X. Shen and R. König (2001) Post-thymic selection of peripheral CD4+ T lymphocytes on class II major histocompatibility antigen-bearing cells. Cell. Mol. Biol. 47: 87-96.
13. X. Shen and R. König (1998) Regulation of T cell immunity and tolerancein vivoby CD4. Int. Immunol. 10: 247-257.
14. W. Zhou and R. König (2003) T cell receptor-independent CD4 signaling: CD4-MHC class II interactions regulate intracellular calcium and cyclic AMP. Cell. Signal. 15: 751-762.
15. T. L. Denning, H. Qi, R. König, K. G. Scott, M. Naganuma, and P. B. Ernst (2003) CD4+ Th cells resembling regulatory T cells that inhibit chronic colitis differentiate in the absence of interactions between CD4 and class II MHC. J. Immunol. 171: 2279-2286.
16. S. Gilfillan, X. Shen, and R. König (1998) Selection and function of CD4+ T lymphocytes in transgenic mice expressing mutant MHC class II molecules deficient in their interaction with CD4. J. Immunol. 161: 6629-6637.
17. R. Maroto, X. Shen, and R. König (1999) Requirement for efficient interactions between CD4 and MHC class II molecules for survival of resting CD4+ T lymphocytesin vivoand for activation-induced cell death. J. Immunol. 162: 5973-5980.
18. R. König, X. Shen, R. Maroto, and T. L. Denning (2002) The role of CD4 in regulating homeostasis of T helper cells. Immunol. Res. 25:115-130.
19. R. König, X. Shen, and R. N. Germain (1995) Involvement of both MHC class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation. J. Exp. Med. 182: 779-787.
20. R. König, S. Fleury, and R. N. Germain (1996) The structural basis of CD4-MHC class II interactions: Coreceptor contributions to T cell receptor antigen recognition and oligomerization-dependent signal transduction. Curr. Top. Microbiol. Immunol. 205: 19-46.
21. R. König, L.-Y. Huang, and R. N. Germain (1992) MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8. Nature 356: 796-798.
22. R. König, H. Kindle, J.G. Kunkel, and B. Lanzrein (1988) Vitellogenesis in the cockroachNauphoeta cinerea: Separation of two classes of ovarian binding sites and calcium effects on binding and uptake. Arch. Insect Biochem. Physiol. 9: 323-338.
23. R. König, G. Ashwell, and J.A. Hanover (1989) Overexpression and biosynthesis of CD4 in Chinese hamster ovary cells: Coamplification using the multiple drug resistance gene. Proc. Natl. Acad. Sci. U.S.A. 86: 9188-9192.
24. R. König, G. Ashwell, and J.A. Hanover (1988) Glycosylation of CD4: Tunicamycin inhibits surface expression. J. Biol. Chem. 263: 9502-9507.
25. R. König and W. Zhou (2004) Signal transduction in T helper cells: CD4 coreceptors exert complex regulatory effects on T cell activation and function. Curr. Issues Mol. Biol. 6: 1-15.
26. R. König (2002) Interactions between MHC molecules and co-receptors of the TCR. Curr. Opin. Immunol. 14: 75-83.
27. L. Wang, J. J. Y. Chen, B. B. Gelman, R. König, and M. W. Cloyd (1999) A novel mechanism of CD4 lymphocyte depletion involves HIV’s effects on resting lymphocytes: induction of lymph node homing and apoptosis upon secondary signaling through homing receptors. J. Immunol. 162: 268-276.
28. K. Lee, X. Shen, and R. König (2001) Effects of cadmium and vanadium ions on antigen-induced signaling in CD4+ T cells. Toxicology 169: 53-65.
29. D. P. Metz, D. L. Farber, R. König, and K. Bottomly (1997) Regulation of memory CD4 T cell adhesion by CD4-MHC class II interaction. J. Immunol. 159: 2567-2573.

Profile Details

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