Biography

Dr. Zdenek Hel

Department of Pathology

University Of Alabama at Birmingham, USA


Email: [email protected]


Qualifications

1997 Ph.D., McGill University, Canada

1990 M.Sc., Charles University, Czech Republic


Publications (selected)

  1. Miková, E., Černý, V., Novotná, O., Petrásková, P., Boráková, K., Hel, Z., & Hrdý, J. (2024). Immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial function. Frontiers in Immunology, 15, 1368624.
  2. Ong, K. L., Davis, M. D., Purnell, K. K., Cutshall, H., Pal, H. C., Connelly, A. N., ... & Hel, Z. (2023). Distinct phenotype of neutrophil, monocyte, and eosinophil populations indicates altered myelopoiesis in a subset of patients with multiple myeloma. Frontiers in Oncology, 12, 1074779.
  3. Calero Valdez, A., Iftekhar, E. N., Oliu-Barton, M., Böhm, R., Cuschieri, S., Czypionka, T., ... & Wolff, G. (2022). Europe must come together to confront omicron.
  4. Connelly, A. N., Huijbregts, R. P., Pal, H. C., Kuznetsova, V., Davis, M. D., Ong, K. L., ... & Hel, Z. (2022). Optimization of methods for the accurate characterization of whole blood neutrophils. Scientific Reports, 12(1), 3667.
  5. Priesemann, V., Balling, R., Brinkmann, M. M., Ciesek, S., Czypionka, T., Eckerle, I., ... & Szczurek, E. (2021). An action plan for pan-European defence against new SARS-CoV-2 variants. The Lancet, 397(10273), 469-470.
  6. Vlkova, M., Chovancova, Z., Nechvatalova, J., Connelly, A. N., Davis, M. D., Slanina, P., ... & Hel, Z. (2019). Neutrophil and granulocytic myeloid-derived suppressor cell–mediated T cell suppression significantly contributes to immune dysregulation in common variable immunodeficiency disorders. The Journal of Immunology, 202(1), 93-104.
  7. Jimenez, R. V., Kuznetsova, V., Connelly, A. N., Hel, Z., & Szalai, A. J. (2019). C-reactive protein promotes the expansion of myeloid derived cells with suppressor functions. Frontiers in immunology, 10, 2183.
  8. Polis, C. B., Achilles, S. L., Hel, Z., & Hapgood, J. P. (2018). Is a lower-dose, subcutaneous contraceptive injectable containing depot medroxyprogesterone acetate likely to impact women's risk of HIV?. Contraception, 97(3), 191-197.
  9. Hapgood, J. P., Kaushic, C., & Hel, Z. (2018). Hormonal contraception and HIV-1 acquisition: biological mechanisms. Endocrine reviews, 39(1), 36-78.
  10. Hel, Z., Xu, J., Denning, W. L., Helton, E. S., Huijbregts, R. P., Heath, S. L., ... & Mestecky, J. (2017). Dysregulation of systemic and mucosal humoral responses to microbial and food antigens as a factor contributing to microbial translocation and chronic inflammation in HIV-1 infection. PLoS pathogens, 13(1), e1006087.
  11. Tryniszewska, E., Nacsa, J., Lewis, M.G., Silvera, P., Venzon, D.,Hel, Z., Washington Parks, R., Maniuszko, M., Tartaglia, J., Smith, K.A., and G. Franchini. 2002. Vaccination of macaques with long standing SIVmac251 infection lowers the viral set point after cessation of antiretroviral therapy.J. Immunol.169:5347-5357.
  12. Stevceva, L., Tryniszewska, E.,Hel, Z., Nacsa, J., Kelsall, B., Washington-Parks, R., and G. Franchini. 2001. Differences in time of virus appearance in the blood and virus-specific immune responses in intravenous and intrarectal primary SIVmac251 infection of rhesus macaques; a pilot study.BMC Infect. Dis.1:9.
  13. Stevceva, L., Kelsall, B., Nacsa, J., Moniuszko, M.,Hel, Z., Tryniszewska, E., and G. Franchini. 2002. Cervicovaginal lamina propria lymphocytes: Phenotypic characterization and their importance in cytotoxic T-lymphocyte responses to Simian immunodeficiency virus SIV(mac251).J. Virol.76: 9-18.
  14. Pal, R., Venzon, D., Letvin, N.L., Santra, S., Montefiori, D.C., Miller, N.R., Tryniszewska, E., Lewis, M.G., VanCott, T.C., Hirsch, V., Woodward, R., Gibson, A., Grace, M., Dobratz, E., Markham, P.D.,Hel, Z., Nacsa, J., Klein, M., Tartaglia, J., and G. Franchini. 2002. ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay Simian immunodeficiency virus SIVmac-induced immunodeficiency.J. Virol.76: 292-302.
  15. Olivier, M., Cook, P., Desanctis, J.,Hel, Z., Wojciechowski, W., Reiner, N.E., Skamene, E., and D. Radzioch.1998. Phenotypic difference between Bcg(r) and Bcg(s) macrophages is related to differences in protein-kinase-C-dependent signalling.Eur. J. Biochem.251:734-743.
  16. Hel, Z., Venzon,D., Poudyal, M., Tsai, W.P., Giuliani, L., Woodward, R., Chougnet, C., Shearer, G., Altman, J., Watkins,D., Bischofberger, N., Abimuku, A., Markham, P., Tattaglia, J., and Franchini, G. 2000. Viremia control following structured treatment interruption and therapeutic immunization of SIV251 -infected macaques.Nature Med.6:1140-6.
  17. Hel, Z., Tsai, W.-P., Tryniszewska, E., Nacsa, J., Markham, P.D., Lewis, M.G., Pavlakis, G.N., Felber, B.K., Tartaglia, J., and Franchini, G. 2006. Improved vaccine protection from simian AIDS by the addition of nonstructural SIV genes. J. Immunol. 176:85-96.
  18. Hel, Z., Tsai, W.P., Thornton, A., Nacsa, J., Giuliani, L., Tryniszewska, E., Poudyal, M., Venzon, D., Wang, X., Altman, J., Watkins, D.I., Lu, W., von Gegerfelt, A., Felber, B.K., Tartaglia, J., Pavlakis, G.N., and G. Franchini. 2001. Potentiation of Simian immunodeficiency virus (SIV)-specific CD4(+) and CD8(+) T cell responses by a DNA-SIV and NYVAC-SIV prime/boost regimen.J. Immunol.167: 7180-7191.
  19. Hel, Z., Tryniszewska, E., Johnson, J.M., Harrod, R., Fullen, J., Kalyanaraman, V.S., Altman, J.D., McNally, J., Kaprova, T., Felber, B.K., Tartaglia, J., and G. Franchini. 2002. Design and in vivo immunogenicity of a polyvalent vaccine based on SIVmac regulatory genes.DNA Cell. Biol. 21:619-626.
  20. Hel, Z., Skamene, E., and D. Radzioch. 1996. Two distinct regions in the 3'-UTR of tumor necrosis factor-α mRNA form complexes with macrophage proteins.Mol. Cell. Biol.16:5579-5590.
  21. Hel, Z., Nacsa, J., Tsai, W.P., Thornton, A., Giuliani, L., Tartaglia, J., and G. Franchini.2002. Equivalent immunogenicity of the highly attenuated poxvirus-based ALVAC-SIV and NYVAC-SIV vaccine candidates in SIVmac251-infected macaques.Virology304:125-134.
  22. Hel, Z., Nacsa, J., Kelsall, B., Tsai, W.P., Letvin, N., Parks, R.W., Tryniszewska, E., Picker, L., Lewis, M.G., Edghill-Smith, Y., Moniuszko, M., Pal, R., Stevceva, L., Altman, J.D., Allen, T.M., Watkins, D., Torres, J.V., Berzofsky, J.A., Belyakov, I.M., Strober, W., and G. Franchini. 2001. Impairment of Gag-Specific CD8(+) T-Cell function in mucosal and systemic compartments of Simian immunodeficiency virus mac251- and Simian-human immunodeficiency virus KU2-infected macaques.J. Virol.75:11483-95.
  23. Hel, Z., Johnson, J.M., Tryniszewska, E., Tsai, W.P., Harrod, R., Fullen, J., Tartaglia, J., and G. Franchini. 2002. A novel chimeric Rev, Tat, and Nef (Retanef) antigen as a component of an SIV/HIV vaccine.Vaccine20:3171-3186.
  24. Hel, Z., DiMarco, S., and D. Radzioch. 1998. Characterization of the RNA-binding proteins forming complexes with a novel putative regulatory region in the 3'-UTR of TNF-α mRNA.Nuc. Acid Res.26:2803-2812.
  25. Hel, Z. Nacsa,J., Tryniszewska, E., Tsai, W.P., Washington-Parks, R., Montefiori, D.C., Felber, B.K., Pavlakis, G.N., J., and G. Franchini. 2002. Containment of SIV infection in Tartaglia, vaccinated macaques: Correlation with the magnitude of virus-specific pre- and post-challenge CD4+ and CD8+ T-cell responses.J. Immunol.169:4778-4787.
  26. Garnon, J., Lachance, C., Di Marco, S., Hel, Z., Marion, D., Ruiz, M.C., Newkirk, M.M., Khandjian, E.W., and D. Radzioch. 2005. Fragile X-related proteinFXR1P regulates proinflammatory cytokine tumor necrosis factor expression at the posttranscriptional level. J. Biol. Chem.280:5750-63.
  27. Franchini, G., Nacsa, J.,Hel, Z., and E. Tryniszewska. 2002. Immune intervention strategies for HIV-1 infection of humans in the SIV macaque model.Vaccine 20 Suppl 4:A52-60.
  28. DiMarco, S.,Hel, Z., Lachance, C., Furneaux, H., and D. Radzioch. 2001. Polymorphism in the 3'-untranslated region of TNF-α mRNA impairs binding of the post-transcriptional regulatory protein HuR to TNFalpha mRNA.Nucleic Acids Res.29:863-71.
  29. Belyakov, I.M.,Hel, Z., Kelsall, B., Kuznetsov, V.A., Ahlers, J.D., Nacsa, J., Watkins, D.I., Allen, T.M., Sette, A., Altman, J., Woodward, R., Markham, P.D., Clements, J.D., Franchini, G., Strober, W., and J. A. Berzofsky. 2001. Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques.Nature Med.7:1320-6.


Profile Details

https://scholars.uab.edu/2130-zdenek-hel
https://scholar.google.com/citations?user=v6_iCJIAAAAJ&hl=en&oi=ao
https://www.researchgate.net/profile/Zdenek-Hel
https://orcid.org/0000-0002-4923-4794
https://loop.frontiersin.org/people/41580

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