Prof. Wei-Yi Ong

National University of Singapore, Singapore

Email: [email protected]

Qualifications

1991 Ph.D., National University of Singapore, Singapore

1985 B.Sc., National University of Singapore, Singapore

Publications (Selected)

1. Leow DM, Cheah IK, Chen L, Ng YK, Yeo CJ, Halliwell B, Ong WY. Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons. Antioxidants (Basel). 2024 Jun 5;13(6):693. doi: 10.3390/antiox13060693. PMID: 38929132; PMCID: PMC11200999.
2. Leow DM, Ng YK, Wang LC, Koh HW, Zhao T, Khong ZJ, Tabaglio T, Narayanan G, Giadone RM, Sobota RM, Ng SY, Teo AK, Parson SH, Rubin LL, Ong WY, Darras BT, Yeo CJ. Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy. J Clin Invest. 2024 May 9;134(12):e173702. doi: 10.1172/JCI173702. Epub ahead of print. PMID: 38722695; PMCID: PMC11178536.
3. Ha HT, Liu S, Nguyen XT, Vo LK, Leong NC, Nguyen DT, Balamurugan S, Lim PY, Wu Y, Seong E, Nguyen TQ, Oh J, Wenk MR, Cazenave-Gassiot A, Yapici Z, Ong WY, Burmeister M, Nguyen LN. Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models. JCI Insight. 2024 Mar 7;9(8):e175462. doi: 10.1172/jci.insight.175462. PMID: 38451736; PMCID: PMC11141868.
4. Chayaburakul K, Ong WY, Herr DR, Kobutree P, Chantra K. Differences in the ultrastructure of neurons in the spinal ganglion and dorsal rootlet between rats treated with cisplatin only versus co-administration with a sphingosine 1-phosphate receptor 2 agonist in attenuating neuropathy and allodynia. J Peripher Nerv Syst. 2023 Sep;28(3):476-489. doi: 10.1111/jns.12582. Epub 2023 Aug 3. PMID: 37483146.
5. Kamarudin JBM, Sun B, Foo ASC, Lim XY, Judd H, Tan X, Tan XH, Razar RBBA, Liu M, Zhong J, Chua JJE, Ng CWQ, Goh JCH, Tan TZ, Parikh BH, Su X, Kumar AP, Ong WY, Yamaguchi N, Set SY, Yip GW, Zhang Y, Teh DBL. SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy. ACS Nano. 2023 Jun 27;17(12):11593-11606. doi: 10.1021/acsnano.3c01916. Epub 2023 Jun 12. PMID: 37306553.
6. Farooqui AA, Farooqui T, Sun GY, Lin TN, Teh DBL, Ong WY. COVID-19, Blood Lipid Changes, and Thrombosis. Biomedicines. 2023 Apr 15;11(4):1181. doi: 10.3390/biomedicines11041181. PMID: 37189799; PMCID: PMC10135929.
7. Leow DM, Cheah IK, Fong ZW, Halliwell B, Ong WY. Protective Effect of Ergothioneine against 7-Ketocholesterol-Induced Mitochondrial Damage in hCMEC/D3 Human Brain Endothelial Cells. Int J Mol Sci. 2023 Mar 13;24(6):5498. doi: 10.3390/ijms24065498. PMID: 36982572; PMCID: PMC10056831.
8. Ong WY, Kao MH, Cheung WM, Leow DM, Cheah IK, Lin TN. Protective Effect of Ergothioneine Against Stroke in Rodent Models. Neuromolecular Med. 2023 Jun;25(2):205-216. doi: 10.1007/s12017-022-08727-w. Epub 2022 Oct 19. PMID: 36261765.
9. Ong WY, Leow DM, Herr DR, Yeo CJ. What Do Randomized Controlled Trials Inform Us About Potential Disease-Modifying Strategies for Parkinson's Disease? Neuromolecular Med. 2023 Mar;25(1):1-13. doi: 10.1007/s12017-022-08718-x. Epub 2022 Jul 1. PMID: 35776238.
10. Ong WY, Herr DR, Sun GY, Lin TN. Anti-Inflammatory Effects of Phytochemical Components of Clinacanthus nutans. Molecules. 2022 Jun 4;27(11):3607. doi: 10.3390/molecules27113607. PMID: 35684542; PMCID: PMC9182488.
11. Ong WY, Satish RL, Herr DR. ACE2, Circumventricular Organs and the Hypothalamus, and COVID-19. Neuromolecular Med. 2022 Dec;24(4):363-373. doi: 10.1007/s12017-022-08706-1. Epub 2022 Apr 22. PMID: 35451691; PMCID: PMC9023728.
12. Soh S, Ong WY. Effect of Withanolide A on 7-Ketocholesterol Induced Cytotoxicity in hCMEC/D3 Brain Endothelial Cells. Cells. 2022 Jan 28;11(3):457. doi: 10.3390/cells11030457. PMID: 35159267; PMCID: PMC8834337.
13. Jo J, Yang L, Tran HD, Yu W, Sun AX, Chang YY, Jung BC, Lee SJ, Saw TY, Xiao B, Khoo ATT, Yaw LP, Xie JJ, Lokman H, Ong WY, Lim GGY, Lim KL, Tan EK, Ng HH, Je HS. Lewy Body-like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α-Synuclein Mutations. Ann Neurol. 2021 Sep;90(3):490-505. doi: 10.1002/ana.26166. Epub 2021 Aug 10. PMID: 34288055; PMCID: PMC9543721.

Profile Details

https://medicine.nus.edu.sg/ant/Directory/Acad/Profiles/antongwy.html

https://www.researchgate.net/scientific-contributions/Wei-Yi-Ong-38504956