Prof. Noah Isakov
The Joseph H. Krupp Chair in Cancer Immunobiology
The Shraga Segal Department of Microbiology, Immunology and Genetics
Ben Gurion University of the Negev, USA
Professor
Email: [email protected]
Qualifications
1981 Ph.D., The Weizmann Institute of Science
1976 M.Sc., The Weizmann Institute of Science
1974 B.Sc., Ben Gurion University of the Negev
Publications (Selected)
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Nath, P. R., & Isakov, N. (2024). Mechanisms of Cbl-Mediated Ubiquitination of Proteins in T and Natural Killer Cells and Effects on Immune Cell Functions. Life, 14(12), 1592.
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Sadiq, S. C., Joy, M. P., Aiswarya, S. U., Ajmani, A., Keerthana, C. K., Rayginia, T. P., ... & Anto, R. J. (2024). Unlocking nature’s pharmacy: an in-depth exploration of phytochemicals as potential sources of anti-cancer and anti-inflammatory molecules. Exploration of Drug Science, 2(6), 744-784.
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Isakov, N. (2023). Conformational and functional regulation of the chicken tumor virus number 10 (CT10) regulator of kinase II (CrkII) adaptor protein by cyclophilin A. Exploration of Immunology, 3(3), 217-232.
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Anto, N. P., Muraleedharan, A., Nath, P. R., Sun, Z., Keasar, C., Livneh, E., ... & Isakov, N. (2023). The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C θ via a critical Phospho-Thr-Pro motif in the V3 regulatory domain. Frontiers in Immunology, 14, 1126464.
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Keerthana, C. K., Rayginia, T. P., Shifana, S. C., Anto, N. P., Kalimuthu, K., Isakov, N., & Anto, R. J. (2023). The role of AMPK in cancer metabolism and its impact on the immunomodulation of the tumor microenvironment. Frontiers in immunology, 14, 1114582.
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Anto, N. P., Arya, A. K., Muraleedharan, A., Shaik, J., Nath, P. R., Livneh, E., ... & Isakov, N. (2023). Cyclophilin A associates with and regulates the activity of ZAP70 in TCR/CD3-stimulated T cells. Cellular and Molecular Life Sciences, 80(1), 7.
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Zhong, X., Wu, H., Zhang, W., Gwack, Y., Shang, W., Lee, K. O., ... & Sun, Z. (2022). Decoupling the role of RORγt in the differentiation and effector function of TH17 cells. Science advances, 8(42), eadc9221.
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Zhang, W., Cao, X., Zhong, X., Wu, H., Feng, M., Gwack, Y., ... & Sun, Z. (2022). Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced Treg differentiation via up-regulating Nr4a2. Science Advances, 8(24), eabn7662.
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Nath, L. R., Swetha, M., Vijayakurup, V., Thangarasu, A. K., Haritha, N. H., Shabna, A., ... & Anto, R. J. (2022). Blockade of uttroside b-induced autophagic pro-survival signals augments its chemotherapeutic efficacy against hepatocellular carcinoma. Frontiers in Oncology, 12, 812598.
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Jayaram, D. R., Frost, S., Argov, C., Liju, V. B., Anto, N. P., Muraleedharan, A., ... & Livneh, E. (2021). Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs. Proceedings of the National Academy of Sciences, 118(40), e2018899118.
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Muraleedharan, A., Rotem‐Dai, N., Strominger, I., Anto, N. P., Isakov, N., Monsonego, A., & Livneh, E. (2021). Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes. Glia, 69(3), 697-714.
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Pandya, P., Jethva, M., Rubin, E., Birnbaum, R. Y., Braiman, A., & Isakov, N. (2019). PICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter. Cell Death & Disease, 10(10), 685.
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Pandya, P., Pasvolsky, R., Babichev, Y., Braiman, A., Witte, S., Altman, A., & Isakov, N. (2019). PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene. Biochemical and Biophysical Research Communications, 509(2), 469-475.
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Isakov, N. (2018, February). Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression. In Seminars in cancer biology (Vol. 48, pp. 36-52). Academic Press.
Profile Details
WoS ResearcherID: F-1659-2012
https://orcid.org/0000-0002-1412-0957
https://cris.bgu.ac.il/en/persons/noah-isakov
https://scholar.google.com/citations?user=wrUDHyYAAAAJ&hl=en
https://www.researchgate.net/profile/Noah-Isakov