Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine

China

Research Fields

Neuroimaging and neuropsychological diagnosis of male sexual dysfunction

Central nervous system and psychological factors in andrology

Integrative Chinese and Western clinical medicine for male psychosexual disorders

 

Qualifications

Ph.D., Nanjing University of Chinese Medicine (Integrative Chinese and Western Clinical Medicine, specializing in Male Psychosexual Disorders)

M.D., Nanjing Medical University (Psychiatry and Mental Health, specializing in Psychological and Psychiatric Disorders)

Bachelor of Medicine, Nanjing Medical University (Clinical Medicine, with a focus on Psychological Health)

Licensed Psychotherapist (National Health Professional Qualification)

 

Publications (Selected) (Complete List, 2015–Present)

Note: # indicates co-first author; * indicates corresponding author

1. Ma M, Yu T, Qin Z, Zhao P, Zhao M, Guo J, Huang N, Liu M, Zhang K, Cai Q, Chen J, Wang G. Abnormal regional brain activity associated with relapse in early abstinent methamphetamine-dependent individuals. Sci Rep. 2025 Jul 22;15(1):26657. (IF=3.9; Q1)

2. Song S#, Fang Y#, Wan X#, Shen L, Hu Y, Lu C, Yue T, Chen L, Chen J, Xue M. Changes of regional brain activity following Tuina therapy for patients with painful cervical spondylosis: a resting-state fMRI study. Front Neurol. 2024 Sep 13;15:1399487. (IF=2.7; Q3)

3. Wu L#, Chen J#, Yu Q, Lu C, Shu Y. Hypoxanthine Produces Rapid Antidepressant Effects by Suppressing Inflammation in Serum and Hippocampus. ACS Chem Neurosci. 2024 Oct 23. (IF=4.1; Q2)

4. Wu N#, Zhang N#, Chen J, Zhao T, Gao S, Zhao J, Lv L, Lu M, Yang J, Zhong Q*. It is easy and effective to locate adrenal gland during retroperitoneal laparoscopic left adrenalectomy by the landmark of left PFSV. Sci Rep. 2023 Sep 13;13(1):15148. (IF=4.6; Q2)

5. Zuo W#, Liu X#, Chen J#, Zuo W, Yin Y, Nie X, Tang P, Huang Y, Yu Q, Hu Q, Zhou J, Tan Y, Huang X, Ren Q*. Single-cell sequencing provides insights into the landscape of ovary in PCOS and alterations induced by CUMS. Am J Physiol Endocrinol Metab. 2023;325(4):346-362. (IF=5.1; Q1)

6. Gao S#, Yang X#, Xiao X, Yin S, Guan Y, Chen J, Chen Y. Outcomes and affecting factors for ICSI and microTESE treatments in nonobstructive azoospermia patients with different etiologies: A retrospective analysis. Front Endocrinol. 2022;13:1006208. (IF=6.055; Q1)

7. Ma M#, Xu Y, Xiang Z, Yang X, Guo J, Zhao Y, Hou Z, Feng Y, Chen J, Yuan Y*. Functional whole-brain mechanisms underlying effects of tDCS on athletic performance of male rowing athletes revealed by resting-state fMRI. Front Psychol. 2022;13:1002548. (IF=4.232; Q1)

8. Xiang Z#, Huang Y#, Xu Y#, Liu X, Huang X, Liu T, Yang Z, Jiang L, Chen Y, Chen J. Altered brain activity in diabetic patients with erectile dysfunction revealed by fractional amplitude of low-frequency fluctuation: A resting-state fMRI study. Andrology. 2024;12(1):68-74. (IF=4.456; Q1)

9. Chen J#, Huang X#, Tang Q#, Xiang Z, Xu Y, Liu T, Yang Z, Yang J, Chen Y. Altered regional homogeneity in patients with diabetic erectile dysfunction: a resting-state fMRI study. Front Endocrinol. 2022; 13: 817523. (IF=6.055; Q1)

10. Chen J#, Wu J#, Huang X#, Sun R, Xiang Z, Xu Y, Chen S, Xu W, Yang J, Chen Y. Differences in structural connectivity between diabetic and psychological erectile dysfunction revealed by network-based statistic: a diffusion tensor imaging study. Front Endocrinol. 2022; 13: 892563. (IF=6.055; Q1)

11. Tao R#, Chen J#, Wang D, Li Y, Xiang J, Xiong L, Ji J, Wu J, Zhou S, Jia C, Lv J, Yang J, Tang Q. The Efficacy of Li-ESWT Combined with VED in Diabetic ED Patients Unresponsive to PDE5is: A Single-Center, Randomized Clinical Trial. Front Endocrinol. 2022; 13: 937958. (IF=6.055; Q1)

12. Gao Q#, Wang H#, Han Y#, Lu J, Niu P, Chen J. Abnormal grey matter in identifying primary intravaginal anejaculation patients from healthy controls: a voxel-based morphometry analysis. Sex Med. 2025 Oct 26;13(5): qfaf086. (IF=2.0; Q2)

13. Gao S#, Liu R#, Niu P#, Guan Y, Yuan C, Chen J, Yang X. Neural basis underlying the effects of trait and state anxiety on premature ejaculation revealed by resting-state interhemispheric functional connectivity. J Affect Disord. 2025 Jun 11:119666. (IF=4.9; Q1)

14. Zhang X#, Niu P#, Su M, Zhou L, Huang Y, Chen J, Liu S. Topological differences of striato-thalamo-cortical circuit in functional brain network between premature ejaculation patients with and without depression. Brain Behav. 2024;14(6):e3585. (IF=3.1; Q2)

15. Gao S#, Chen J#, Liu J, Guan Y, Liu R, Yang J, Yang X. Decreased grey matter volume in dorsolateral prefrontal cortex and thalamus accompanied by compensatory increases in middle cingulate gyrus of premature ejaculation patients. Andrology. 2024;12(4):841-849. (IF=4.503; Q1)

16. Chen J#, Wang Q#, Huang X#, Xu Y, Xiang Z, Liu S, Yang J, Chen Y. Potential biomarkers for distinguishing primary from acquired premature ejaculation: A diffusion tensor imaging based network study. Front Neurosci. 2022;16:929567. (IF=5.152; Q2)

17. Xu Y#, Zhang X#, Xiang Z#, Wang Q, Huang X, Liu T, Yang Z, Chen Y, Xue J, Chen J, Yang J. Abnormal Functional Connectivity Between the Left Medial Superior Frontal Gyrus and Amygdala Underlying Abnormal Emotion and Premature Ejaculation: A Resting State fMRI Study. Front Neurosci. 2021;15:704920. (IF=4.677; Q2)

18. Liu S#, Zhang X#, Wang Q#, Xu Y, Huang X, Liu T, Yang Z, Xiang Z, Lu C, Chen Y, Chen J, Yang J. Increased attentional network activity in premature ejaculation patients with anxiety revealed by resting-state functional magnetic resonance imaging. Eur J Neurosci. 2021;54(4):5417-5426. (IF=3.386; Q3)

19. Gao S#, Chen J#, Xu Y, Liu S, Lu C, Guan Y, Yang X. Altered Structural and Functional Connectivity Contribute to Rapid Ejaculation: Insights from a Multimodal Neuroimaging Study. Neuroscience. 2021;471:93-101. (IF=3.590; Q2)

20. Chen J#, Wu W#, Xiang Z, Wang Q, Huang X, Lu C, Liu S, Chen Y, Yang J. Aberrant default mode network and auditory network underlying the sympathetic skin response of the penis (PSSR) of patients with premature ejaculation: a resting-state fMRI study. Andrology. 2021;9(1):277-287. (IF=3.842; Q2)

21. Chen J#, Yang J#, Xiang Z, Huang X, Lu C, Liu S, Chen Y, Hu J. Graph theory analysis reveals premature ejaculation is a brain disorder with altered structural connectivity and depressive symptom: a DTI-based connectome study. Eur J Neurosci. 2021;53(6):1905-1921. (IF=3.386; Q1)

22. Chen J#, Yang J#, Huang X, Lu C, Liu S, Dai Y, Yao Z, Chen Y*, Yu M. Variation in Brain Subcortical Network Topology Between Men With and Without PE: A Diffusion Tensor Imaging Study. J Sex Med. 2020;17(1):48-59. (IF=3.293; Q1)

23. Chen J#, Huang X, Lu C, Liu T, Dai Y, Yao Z, Chen Y*. Graph analysis of DTI-based connectome: decreased local efficiency of subcortical regions in PE patients with high sympathetic activity. Andrology. 2020;8(2):400-406. (IF=2.860; Q2)

24. Chen J#, Yang J#, Huang X, Wang Q, Lu C, Liu S, Chen Y, Ni L. Brain Functional Biomarkers Distinguishing Premature Ejaculation From Anejaculation by ALFF: A Resting-State fMRI Study. J Sex Med. 2020;17(12):2331-2340. (IF=3.293; Q1)

25. Wu N#, Chen JH#, Wang T, Yang BB, Xing SY, Gao SZ, Ni DW, Du GJ, Song T, Han YF, Sun GH, Gao QQ, Xu CL, Dai YT. Altered brain activity associated with premature ejaculation improved by electroacupuncture in rats. Sex Med. 2024;12(4):qfae047. (IF=2.6; Q2)

26. Yang J#, Zhang QJ#, Zhang JY, Wang YM, Zhu GQ, Song NH, Wang ZJ, Chen J, Xia JD. Upregulated expression of NMDA receptor in the paraventricular nucleus shortens ejaculation latency in rats with experimental autoimmune prostatitis. Andrology. 2021;9(1):352-360. (IF=3.842; Q2)

27. Gao QQ#, Chen JH#, Lu JM, Wang B, Han YF, Gao SZ, Yang J, Dai YT. Altered regional brain activity and functional connectivity in primary intravaginal anejaculation patients revealed by resting-state fMRI. Asian J Androl. 2024;26(5):510-516. (IF=2.9; Q2)

28. Gao Q#, Chen J#, Wang B, Hang Y, Gao S, Yang J, Dai Y. Application of the sexual therapy combined with vacuum negative pressure hydropneumatic/pneumatic bubble massage in primary intravaginal anejaculation. Andrology. 2024;12(8):1822-1829. (IF=4.6; Q1)

29. Chen J#, Yang J#, Huang X, Ni L, Qian F, Liu T, Yao Z, Chen Y*. Reduced segregation and integration of structural brain network associated with sympathetic and dorsal penile nerve activity in anejaculation patients: a graph-based connectome study. Andrology. 2020;8(2):392-399. (IF=2.860; Q2)

30. Yang Z#, Lu C#, Wang Q#, Liu T, Xu Y, Huang X, Chen J. Age-related differences of serum total testosterone and psychological factors in patients with erectile dysfunction. Front Endocrinol. 2025;16:1615402. (IF=4.6; Q1)

31. Liu X#, Niu P#, Yang Z, Xu Y, Liu T, Liu S, Chen Y, Chen J*. Altered Effective Connectivity in Reward-Related Circuits of Psychogenic Erectile Dysfunction: Insights From Spectral Dynamic Causal Modeling. Eur J Neurosci. 2025;62(8):e70289. (IF=2.4; Q3)

32. Du GW#, Niu PN#, Yang ZX, Zhang XH, He JC, Liu T, Xu Y, Chen JH*, Chen Y*. Association between metabolic parameters and erection in erectile dysfunction patients with hyperuricemia. Asian J Androl. 2025;27(4):482-487. (IF=3.0; Q2)

33. Liu X#, Niu P#, He J#, Du G, Xu Y, Liu T, Yang Z, Liu S, Chen Y*, Chen J*. Altered brain activity and functional connectivity in psychogenic erectile dysfunction: Combining findings from LOOCV-SVM-RFE and rs-fMRI. Neuroscience. 2025;567:219-226. (IF=2.9; Q2)

34. Qiao Y#, Chen J#, Jiang Y, Zhang Z, Wang H, Liu T, Yang Z, Fu G*, Chen Y*. Gut microbiota composition may be an indicator of erectile dysfunction. Microb Biotechnol. 2024;17(1):e14403. (IF=5.7; Q1)

35. Liu X#, Liu S#, Liu T#, Tang L, Ji M, Xu Y, Xiang Z, Zhou J, Chen Y*, Chen J*. Altered regional brain activity and functional connectivity in resting-state brain networks associated with psychological erectile dysfunction. Front Neurosci. 2023;17:1074327. (IF=5.152; Q2)

36. Chen J, Huang X, Liu S, Lu C, Dai Y, Yao Z, Chen Y*. Disrupted topological properties of brain networks in erectile dysfunction patients owing predominantly to psychological factors: a structural and functional neuroimaging study. Andrology. 2020;8(2):381-391. (IF=2.860; Q2)

37. Gao QQ#, Chen JH#, Chen Y, Song T*, Dai YT. Dynamic infusion cavernosometry and cavernosography for classifying venous erectile dysfunction and its significance for individual treatment. Chin Med J. 2019;132(4):405-410. (IF=1.555; Q3)

38. Chen J, Chen Y*, Gao Q, Chen G, Dai Y, Yao Z, Lu Q. Impaired prefrontal-amygdala pathway, self-reported emotion and erection in psychogenic erectile dysfunction patients with normal nocturnal erection. Front Hum Neurosci. 2018;12:157. (IF=2.871; Q3)

39. Chen J, Chen Y*, Gao Q, Dai Y, Yao Z, Lu Q. Brain structural network topological alterations of the left prefrontal and limbic cortex in psychogenic erectile dysfunction. Int J Neurosci. 2018;128(5):393-403. (IF=1.848; Q4)

40. Chen J, Chen Y*, Chen G, Dai Y, Yao J, Lu Q. Altered brain networks in psychogenic erectile dysfunction: a resting-state fMRI study. Andrology. 2017;5(6):1073-1081. (IF=2.427; Q2)

41. Gao Q#, Chen J#, Zuo W#, Wang B, Song T, Xu C, Yu W, Dai Y, Gao S, Zhu L, Yang J. ADSCs labeled with SPIONs tracked in corpus cavernosum of rat and miniature pig by MR imaging and histological examination. Sci Rep. 2024;14(1):1917. (IF=4.6; Q2)

42. Wang H#, Liu X#, Zhang Z, Han Z, Jiang Y, Qiao Y, Liu T, Chen J, Chen Y. Effects of tadalafil on sexual behavior of male rats induced by chronic unpredictable mild stress. Sex Med. 2023;11(2):1-6. (IF=2.523; Q3)

43. Chen G#, Chen J#, Yang B, Yu W, Chen Y, Dai Y. Dopamine D2 receptors in the basolateral amygdala modulate erectile function in a rat model of nonorganic erectile dysfunction. Andrologia. 2019;51(1):e13160. (IF=1.840; Q3)

44. Chen G#, Yang B#, Chen J#, Zhu L, Jiang H, Yu W, Zang F, Chen Y*, Dai Y. Changes in Male Rat Sexual Behavior and Brain Activity Revealed by Functional Magnetic Resonance Imaging in Response to Chronic Mild Stress. J Sex Med. 2018;15(2):136-147. (IF=3.339; Q1)

45. Xu Y#, Niu P#, Liu T#, Tian J, Wang A, Yang Z, Liu S, Chen Y, Chen J*. Topological abnormalities of left middle orbital frontal gyrus and amygdala associated with hypoactive sexual desire disorder: A diffusion tensor imaging study. Andrology. 2025 May 19. (IF=3.2; Q1)

46. Wang Z#, Wu J#, Deng C, Hu Y, Shi S, Liu S, Huang X, Chen J. Efficacy and brain modulation mechanisms of acupuncture for chronic prostatitis/chronic pelvic pain syndrome revealed by structural MRI changes. Front Neurol. 2025;16:1579484. (IF=2.8; Q2)

47. Huang X#, Chen J#, Liu S#, Gong Q, Liu T, Lu C, Qin Z, Cui H, Chen Y, Zhu Y. Impaired frontal-parietal control network in chronic prostatitis/chronic pelvic pain syndrome revealed by graph theoretical analysis: A DTI study. Eur J Neurosci. 2021;53(4):1060-1071. (IF=3.386; Q3)

 

Profile Details

Position: Deputy Chief Physician, Department of Andrology, Jiangsu Provincial Hospital of Chinese Medicine

Honors & Awards: Outstanding Young Doctor, Jiangsu Provincial Hospital of Chinese Medicine; Wiley Series SCI Journals China Highly Cited Author Award

Clinical Expertise: Specializes in the diagnosis and treatment of psychological and common andrological disorders

Research & Innovations: Developed a diagnostic, classification, and evaluation model for male sexual dysfunction based on neuroimaging and neuropsychological techniques; Developed a comprehensive treatment model for male sexual dysfunction targeting CNS and psychological factors

Professional Affiliations: Vice Chair of the Youth Committee (Nanjing Society of Andrology); Standing Member (Diabetic Encephalopathy Branch, Nanjing Diabetes Complications Society); Member (Sexual Medicine Division, TCM Sexology Division, Psychosexual Health Committee - China Sexology Association); Member (Youth Research Committee - Jiangsu Association of Integrative Medicine); Member (Healthy Lifestyle and Weight Management Committee - Jiangsu Preventive Medicine Association); Member (Microcirculation Branch - Nanjing Diabetes Complications Society); Member (International Society for Sexual Medicine, Asia Pacific Society for Sexual Medicine)

Editorial Roles: Youth Editorial Board Member (Canadian Journal of Urology, Neuroelectronics); Editor/Reviewer (JSM, Andrology, AJA, Chinese Journal of Andrology); Guest Editor for several SCI journals

Academic Achievements: 77 papers as first/corresponding author (51 in SCI journals, IF 179.35; 27 in core Chinese journals); Principal Investigator of 1 NSFC project and 8 provincial/municipal projects; Co-inventor of 4 patents; Contributing author to Wu Jieping Urology, Practical Urology, and multiple national guidelines

 

Link 1: Scopus Profile

https://www.scopus.com/authid/detail.uri?authorId=56500967000

Link 2: Jiangsu Province Hospital of Chinese Medicine - Faculty Profile

http://www.jshtcm.com/en/index.html