Biography

Prof. Hermona Soreq

The Hebrew University of Jerusalem, Israel


Email: [email protected]


Qualifications
2005 The Hebrew University

1976 The Weizmann Institute of Science


Publications (Selected)
  1. Madrer, N., Vaknine-Treidel, S., Zorbaz, T., Tzur, Y., Bennett, E. R., Drori, P., ... & Soreq, H. (2025). Pre-symptomatic Parkinson’s disease blood test quantifying repetitive sequence motifs in transfer RNA fragments. Nature Aging, 1-15.
  2. Treidel, S. V., Lobmaier, S. M., Sharma, R., Madrer, N., Dubnov, S., Shulman, D., ... & Soreq, H. (2025). Maternal prenatal stress induces sex-dependent changes in tRNA fragment families and cholinergic pathways in newborns. Molecular psychiatry.
  3. Erbacher, C., Vaknine-Treidel, S., Madrer, N., Weinbender, S., Evdokimov, D., Unterecker, S., ... & Üçeyler, N. (2022). Altered blood and keratinocyte microRNA/transfer RNA fragment profiles related to fibromyalgia syndrome and its severity. Pain, 10-1097.
  4. Treidel, S. V., Lobmaier, S. M., Sharma, R., Madrer, N., Shulman, D., Greenberg, P., ... & Soreq, H. (2024). Newborn reactions to maternal prenatal stress alter umbilical cord blood tRNA fragments targeting cholinergic transcripts. bioRxiv.
  5. Dubnov, S., Bennett, E. R., Yayon, N., Yakov, O., Bennett, D. A., Seshadri, S., ... & Soreq, H. (2024). Knockout of the longevity gene Klotho perturbs aging and Alzheimer’s disease-linked brain microRNAs and tRNA fragments. Communications Biology, 7(1), 720.
  6. Dubnov, S., Piran, Z., Soreq, H., & Nitzan, M. (2024). Identifying maximally informative signal-aware representations of single-cell data using the Information Bottleneck. bioRxiv, 2024-05.
  7. Tzur, Y., Dubnov, S., Madrer, N., Bar, A., Nadorp, B., Mishra, N., ... & Soreq, H. (2024). Ribosomal protein L24 mediates mammalian microRNA processing in an evolutionarily conserved manner. Cellular and Molecular Life Sciences, 81(1), 55.
  8. Kovarik, Z., & Soreq, H. (2024). Recent advances in cholinergic mechanisms: A preface for the ISCM2022 special issue. Journal of neurochemistry, 168(4), 334-338.
  9. Tzur, Y., Winek, K., Madrer, N., Dubnov, S., Bennett, E. R., Greenberg, D. S., ... & Soreq, H. (2024). Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and Perilipin 2. Molecular Metabolism, 79, 101856.
  10. Dubnov, S., & Soreq, H. (2023). Transfer RNA fragments, from structure to function. In RNA Structure and Function (pp. 1-19). Cham: Springer International Publishing.
  11. Dubnov, S., Bennett, E. R., Yayon, N., Yakov, O., Bennett, D. A., Seshadri, S., ... & Soreq, H. (2024). Knockout of the longevity gene Klotho perturbs aging and Alzheimer’s disease-linked brain microRNAs and tRNA fragments. Communications Biology, 7(1), 720.
  12. Tzur, Y., Winek, K., Madrer, N., Dubnov, S., Bennett, E. R., Greenberg, D. S., ... & Soreq, H. (2024). Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and Perilipin 2. Molecular Metabolism, 79, 101856.
  13. Kern, F., Kuhn, T., Ludwig, N., Simon, M., Gröger, L., Fabis, N., ... & Keller, A. (2023). Ageing-associated small RNA cargo of extracellular vesicles. RNA biology, 20(1), 482-494.
  14. Kovarik, Z., Moshitzky, G., Maček Hrvat, N., & Soreq, H. (2024). Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults. Journal of neurochemistry, 168(4), 355-369.
  15. Yehuda, H., Madrer, N., Goldberg, D., Soreq, H., & Meerson, A. (2023). Inversely Regulated Inflammation-Related Processes Mediate Anxiety–Obesity Links in Zebrafish Larvae and Adults. Cells, 12(13), 1794.
  16. Shulman, D., Dubnov, S., Zorbaz, T., Madrer, N., Paldor, I., Bennett, D. A., ... & Soreq, H. (2023). Sex‐specific declines in cholinergic‐targeting tRNA fragments in the nucleus accumbens in Alzheimer's disease. Alzheimer's & Dementia, 19(11), 5159-5172.
  17. Outeiro, T. F., Alcalay, R. N., Antonini, A., Attems, J., Bonifati, V., Cardoso, F., ... & Ferreira, J. J. (2023). Defining the riddle in order to solve it: there is more than one “Parkinson's disease”. Movement Disorders, 38(7), 1127-1142.
  18. Tzur, Y., Dubnov, S., Madrer, N., Bar, A., Nadorp, B., Mishra, N., ... & Soreq, H. (2023). Ribosomal protein L24 modulates mammalian microRNA processing and transfer RNA fragment production. bioRxiv, 2023-05.
  19. Yehuda, H., Madrer, N., Goldberg, D., Soreq, H., & Meerson, A. (2023). Inversely regulated immune-related processes mediate anxiety-obesity links in zebrafish. bioRxiv, 2023-02.
  20. Lobentanzer, S., Hanin, G., Klein, J., & Soreq, H. (2019). Integrative transcriptomics reveals sexually dimorphic control of the cholinergic/neurokine interface in schizophrenia and bipolar disorder. Cell reports, 29(3), 764-777.
  21. Paldor, I., Madrer, N., Vaknine Treidel, S., Shulman, D., Greenberg, D. S., & Soreq, H. (2023). Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex, and Parkinson's disease‐related changes. Journal of Neurochemistry, 164(5), 671-683.
  22. Yayon, N., Amsalem, O., Zorbaz, T., Yakov, O., Dubnov, S., Winek, K., ... & Soreq, H. (2023). High‐throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory‐deprived cortical cholinergic VIP/CHAT neurons. The EMBO Journal, 42(1), e110565.
  23. Lackie, R. E., de Miranda, A. S., Lim, M. P., Novikov, V., Madrer, N., Karunatilleke, N. C., ... & Prado, M. A. (2022). Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo. Acta Neuropathologica, 144(5), 881-910.
  24. Gok, M., Madrer, N., Zorbaz, T., Bennett, E. R., Greenberg, D., Bennett, D. A., & Soreq, H. (2022). Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer’s and Parkinson’s disease. Frontiers in Molecular Neuroscience, 15, 941467.
  25. Paldor, I., Madrer, N., Vaknine Treidel, S., Shulman, D., Greenberg, D. S., & Soreq, H. (2023). Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex, and Parkinson's disease‐related changes. Journal of Neurochemistry, 164(5), 671-683.


Profile Details

https://orcid.org/0000-0002-0955-526X

https://www.bio.huji.ac.il/en/content/soreq-hermona

https://scholar.google.com/citations?user=n_y7gmwAAAAJ&hl=zh-CN

https://www.researchgate.net/profile/Hermona-Soreq

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