Dr. Dario C. Ramirez

Universidad Nacional de San Luis, Argentina

Email: [email protected]

Qualifications

2008 NIH PI Training, Molecular Physiology, National Institute of Environmental Health Sciences, RTP, NC, USA

2006 Post-Doctoral Training, Pharmacology, National Institute of Environmental Health Sciences, RTP, NC, USA

2001 M.Sc., Immunology, National University of San Luis, San Luis, Argentina

2000 Ph.D., Biochemistry, National University of San Luis, San Luis, Argentina

1996 M.Sc., Biochemistry, National University of San Luis, San Luis, Argentina

Publications (Selected)

1. Gomez Mejiba, SE; Zhai, Z.; Muñoz, MD; Della Vedova, MC; Ranguelova, K; Ashby, MT & Ramirez, DC. 2015. Radicalization of glyceraldehyde-3-phosphate dehydrogenase by HOCl in living cells. Journal of Enzyme Engineering. 4:2.10000134.
2. Della-Vedova, MC; Muñoz, MD; Santillan, LD; Plateo-Pignatari, MG; Germano, MJ; Rinaldi Tosi, ME; Garcia, S; Gomez, NN; Fornes, MW; Gomez Mejiba, SE; Ramirez, DC. 2016. A Mouse model of diet-induced obesity resembling most features of human metabolic síndrome. Nutr. & Metab. Insights, 9: 93-102.
3. Delsouc, MB; Della Vedova, MC; Ramirez, DC; Anzulovich, AM.; Delgado, M; Casai, M; 2016. Oxidative stress and altered steroidogenesis in the ovary by cholinergic stimulation of coeliac ganglion in the first proestrous in rats. Implication of nitric oxide. Nitric Oxide, 53:45-53.
4. Germanó, MJ; Muñoz, MD; Ramirez, DC; Enriz, RD & Giannini, F.A. 2017. Evaluation of the toxicity of extracts from grape Mrac Polar. World J. Pharmacol. Res. 6(4):888-896. Doi: 10.20959/wjpr20174-8027.
5. Delsouc, MB, Delgado, M; Ramirez, DC; Casai, M. 2018. The production of nitric oxide in the celiac ganglion moledulates the effect of cholinergic neurotransmision in the rat ovary during the preovulatory period. Nitric Oxide, 75-85-94. doi: 10.1016/j.niox.2018.02.010.
6. Delsouc, MB, Delgado, M; Ramirez, DC; Casai, M. 2018. The production of nitric oxide in the celiac ganglion moledulates the effect of cholinergic neurotransmision in the rat ovary during the preovulatory period. Nitric Oxide, 75-85-94.
7. Muñoz, MD, Della Vedova, MC, Bushel, PR, Ganini Da Silva, D, Mason, RP, Zhai, Z, Gomez-Mejiba SE, Ramirez DC. The nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide dampens lipopolysaccharide-induced transcriptomic changes in macrophages. 2018. Inflammation Research. 67(6): 515-530. IF: 2.99. DOI: 10.1007/s00011-018-1141-z.
8. Muñoz, MD., Della Vedova, MC, Gomez Mejiba, SE, Ramirez DC. The nitrones spin trap 5,5-dimethyl-1-pyrroline N-oxide prevents lipopolysaccharide induced M1-like phenotype in RAW264.7 cells. The Pharmaceutical and Chemical Journal, 2018, 5(2):1-8. http://tpcj.org/archive/volume-5-issue-2-2018.
9. Plateo Pignatari, M.G.; Della Vedova M.C., Perez Díaz M.F., Navigatore L., Giménez M.S., Ramírez D.C. 2018. Effects of a subchronic intoxication with cadmium in the hippocampus of rats fed a soybean-based diet. Appl. Cell. Biol. 6(2):18-33. ISSN : 2320-1991 Online - ISSN : 2320-1983 Print.
10. Delsouc MB, Ghersa F, Ramírez DC, Della Vedova MC, Gil RA, Vallcaneras SS, Casais M. Endometriosis progression in tumor necrosis factor receptor p55-deficient mice: Impact on oxidative/nitrosative stress and metallomic profile. IF: 3.75. J Trace Elem Med Biol. 2019 52:157-165. doi: 10.1016/j.jtemb.2018.12.013.
11. Muñoz MD, Gutierrez LJ, Delignat S, Russick J, Gomez Mejiba SE, Lacroix-Desmazes S, Enriz RD, Ramirez DC. The nitrone spin trap DMPO binds to toll-like receptor-2-TIR-BB-loop domain and dampens downstream inflammatory signaling. BBA Molecular Basis Diseases. 2019 Jan 23. pii: S0925-4439(19)30005-5. doi: 10.1016/j.bbadis.2019.01.005. IF: 5.1.
12. Matías F. F. Pérez Díaz, Gabriela Plateo Pignatari, Verónica P. Filippa, Fabián H. Mohamed, Eduardo J. Marchevsky, María S. Gimenez, Ramirez, DC. 2019. A soybean-based diet protects against cadmium-induced apoptosis in the aorta of rat. IF: 3.75. J Trace Elem Med Biol. 2019 Mar;52:239-246. doi: 10.1016/j.jtemb.2019.01.007.
13. Della Vedova, MC; Soler Garcia, FM ; Muñoz, MD; Fornes, MW ; Gomez Mejiba, SE; Gómez, NN; Ramírez, DC. 2019. Diet-induced pulmonary inflammation and incipient fibrosis in mice. A possible role of neutrophilic inflammation. Inflammation. DOI: 10.1007/s10753-019-01051-9. IF: 2.94.
14. Gomez Mejiba, SE & Ramirez, DC. 2019. Trapping of DNA radicals with the nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide and genotoxic damage: recent advances using immune-spin trapping technology. Mutation Research: Reviews in Mutation Research. DOI: 10.1016/j.mrrev.2019.108283 – IF 6.08.
15. Funes AB, Saez Lancelotti TE, Santillan LD, Della Vedova MC, Monclus MA, Cabrillana ME, Gomez Mejiba SE, Fornes MW & Ramirez DC. 2019. A chronic high-fat diet causes spermatogenesis defects in C57BL/6J mice. Heliyon, 5, e02868. DOI: 10.1016/j.heliyon.2019.e02868.
16. Farías ME, Marani MM, Ramírez DC, Niebylski AM, Correa NM, Molina, PG. 2019. Polyclonal Antibody Production Anti Pc_312-324 Peptide. Its Potential Use in Electrochemical Immunosensors for Transgenic Soybean Detection. Bioelectrochemistry. Bioelectrochemistry. 2019,4;131:107397. IF: 4.7 – DOI: [email protected].
17. Claveles Casas FN, Barrera FS, Lopez CM, Di Sciullo MP, Gomez Mejiba S & Ramirez DC. 2019. Therapeutic targets to reduce the contribution of pulmonary neutrophilic inflammation towards obesity-associated comorbidities: a mini-review. Open J Pharm Sci Res. 1: 123-133. DOI: 10.36811/ojpsr.2019.110006.
18. Germano, MJ, Muñoz, MD, Della Vedova, MC, Feresin, GE, Rinaldi Tossi, M, Enriz, RD, Ramirez, DC & Gianinni, F.A. 2020. Anti-oxidant and anti-inflammatory effect of polar extracts obtained from waste product of wine making. Nat. Prod. Res. DOI: 10.1080/14786419.2020.1721492 IF:2.06.
19. Ramirez, DC & Gomez Mejiba, SE. 2020. Pulmonary Neutrophilic inflammation and noncommunicable diseases: Pathophysiology, redox mechanisms, biomarkers, and Therapeutics. Antiox. Redox. Signal. 33(3): 121-127. DOI: 10.1089/ars.2020.8098.
20. Ledezma C, Coria-Lucero, C., Delsouc, MB, Casais, M, Della Vedova, MC, Ramirez, DC, Devia, MC, Delgado, MS, Navigatore-Fonzo, L, Anzulovich, AC 2021. Intracerebroventricular injection of beta-amyloid intracerebro-ventricular injection of beta amyloid peptide (1-42) modifies the temporal organization of antioxidant defenses and oxidative stress in the pre-frontal cortex. Neurosciences. 458:99-107. IF. 3.06. DOI: 10.1016/j.neuroscience.2020.08.016.10.1016/j.neuroscience.2020.08.016
21. Alfaro, M.; Mazaffero, P.; Golini, R.; Leporatti, J.; Della Vedova, MC; Ramirez, DC; Delsouc, B.; Casais, M; Anzulovich, AC, Navegatore, L.. 2021. An intracerebrovascular injection of amyloid-beta peptide (1-42) aggregates modifies daily temporal organization of clock factor expression, protein carbonyls and antioxidant enzymes in rat hippocampus. Brain Research. DOI: 10.1016/j.brainres.2021.147449.
22. Hemakumar C., Ravindranath B.S.*, Ramirez D.C.* & Kiran S.V. 2023. Marmesin and marmelosin interact with the heparan sulfatase-2 active site: Potential mechanism for phytochemicals from bael fruit extract as antitumor therapeutics. Oxidative Medicine and Cellular Longevity- vol. 2023, Article ID 9982194, 19 pages. DOI: 10.1155/2023/9982194.
23. Coria Lucero C., Ledezma, C, Leporatti, J., Ramirez DC, Ghersid, M., Delgado, M., Anzulovich, AC, Navigatore Fonzo, L. 2023. An intracerebroventricular injection of AΒ (1-42) modifies temporal profiles of spatial memory performance and oxidative status in the temporal cortex rat. Brain Res. DOI. 10.1016/j.brainres.2023.148242.
24. Staurini S, Niclis C, Calcagni MS, Ramirez DC, Gomez Mejiba SE & Aballay LR. 2023. Condiciones socioeconómicas desfavorables asociadas a la presencia de obesidad y sus comorbilidades metabólicas en adultos de San Luis, Argentina. Rev. Fac. Cien. Med Univ. Nac Cordoba, 80(4): 420–438. doi: 10.31053/1853.0605.v80.n4.40737.
25. DiMarco Polencia, FCD, Diaz, MG, Vega-Hissi, E. Gomez Mejiba, SE, Ramirez, DC & Garro Martinez, J. 2024. Hypochlorous Acid Scavenger Activity of Heteroaryl-Nitrones. A Combined Experimental and Theoretical Study. Chemistry Select. DOI 10.1002/slct.202303359.
26. Ravindranath, B., Grewall, A., Hemakumar, C., Ramírez, DC*. and Gomez Mejiba, SE. 2024. Computational Prediction of Crucial Genes Involved in Gonorrhea Infection and Neoplastic Transformation: A Multiomics Approach. SSRN: http://dx.doi.org/ 10.2139/ssrn.4697705.
27. Hema Kumar C*, Yogitha PN, Sushmitha S, Bee S, Shafi S, Khan MY, Ramirez D C*, Gomez Mejiba SE*. 2024. Recent advances in the bioremediation of soils contaminated with heavy metals. EarthArXiv. https://doi.org/10.31223/X5ZX25.
28. Santhosh KH, Krishna, V, Kemparaju K., Manjunatha, H., Shashi Kumar, R., Mukherjee A., Gomez Mejiba, SE, Ramirez, DC*, Ravindranath, BS. 2024. β-keto amyrin isolated from Cryptostegia grandiflora R. br. inhibits inflammation caused by Daboia russellii viper venom: Direct binding of β-keto amyrin to phospholipase A2. TOXICON. https://doi.org/10.1016/j.toxicon.2024.107679.
29. Ramirez DC & Gomez Mejiba, SE. 2024. Trapping DNA-radicals with DMPO reduced hypochlorous acid-induced 8-oxo-7,8-dihydro-2'-deoxyguanosine and mutagenesis in lung epithelial cells. BioXrxy. doi: https://doi.org/10.1101/2024.06.18.599657. https://sciencecast.org/casts/b5gfc0q4ohds.
30. Ortiz Flores, RM; Cáceres, CS; Cortiñas, TI; Gomez Mejiba, SE; Sasso, CV, Ramirez, DC*; Mattar Domínguez, MA. 2024. Exotoxins secreted by Clostridium septicum induce macrophage death: implications for bacterial immune evasion mechanisms at infection sites. BioXrxv. https://doi.org/10.1101/2024.06.18.599648.
31. Ravindranath, BS; Vratin, S; Lakshmi, BS; Ramirez, DC*; Gomez Mejiba, SE. 2024. Drugs targeting microRNAs that regulate DNA damage sensing and repair mechanisms: A computational drug discovery approach. BioXrxy. https://doi.org/10.1101/2024.06.18.599590 / https://www.biorxiv.org/content/10.1101/2024.06.18.599590v1.
32. Vasquez-Gomez M, Filippa, V. Acosta M., Mohamed F., Campo Verde F, Ferrari C., Jahn G., Giménez M.S, Ramirez D.C.*, Gomez Mejiba, S.E. 2024. Dietary vitamin A deficiency causes apoptosis in the mammary gland. BioXrxy doi: https://doi.org/10.1101/2024.06.26.600922.
33. Ponce IT, Coria-Lucero CD, Lacoste MG, Della Vedova MC, Devia CM, Ramírez DC, Gomez Mejiba SE, Delgado MS, Anzulovich AC. 2024. The circadian rhythms of antioxidant enzyme activity, clock, and inflammatory factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for healthy aging. J Cell Neurosci Oxid Stress 16:1, 1183 – 1194. Dergy Park Akademik. https://doi.org/10.37212/jcnos.1460272.
34. Ravindranath, B., Ananya G., Hemakumar, C., Ramírez, DC*, and Gomez Mejiba, SE. 2024. Computational Prediction of Crucial Genes Involved in Gonorrhea Infection and Neoplastic Transformation: A Multiomics Approach. Microbial Pathogenesis. https://authors.elsevier.com/a/1jMag38ed-bSb9 https://doi.org/10.1016/j.micpath.2024.106770.
35. Ortiz Flores, RM; Cáceres, CS; Cortiñas, TI; Gomez Mejiba, SE; Sasso, CV, Ramirez, DC*; Mattar Domínguez, MA. 2024. Exotoxins secreted by Clostridium septicum induce macrophage death: implications for bacterial immune evasion mechanisms at infection sites. TOXICON. https://doi.org/10.1016/j.toxicon.2024.108070.

Profile Details

WoS ResearcherID: K-3312-2013

https://orcid.org/0000-0001-6725-3326

https://loop.frontiersin.org/people/44979/overview

https://www.researchgate.net/profile/Dario-Ramirez