Biography

Dr. Izabela Tworowska

Therapeutic Nuclear Medicine Research Institute, USA


Email: [email protected]


Qualifications

2001 Ph.D., Polish Academy of Sciences, Poland

1992 M.Sc., Pharm., Clinical Pharmacy, Medical University, Poland


Publications (selected)

  1. Strosberg, J. R., Naqvi, S., Cohn, A. L., Delpassand, E. S., Wagner, V. J., Tworowska, I., ... & Maluccio, M. A. (2024). Safety, tolerability and efficacy of 212Pb-DOTAMTATE as a targeted alpha therapy for subjects with unresectable or metastatic somatostatin receptor-expressing gastroenteropancreatic neuroendocrine tumors (SSTR+ GEP-NETs): A phase 2 study.
  2. Delpassand, E. S., Tworowska, I., Esfandiari, R., Torgue, J., Hurt, J., Shafie, A., & Núñez, R. (2022). Targeted α-emitter therapy with 212Pb-DOTAMTATE for the treatment of metastatic SSTR-expressing neuroendocrine tumors: first-in-humans dose-escalation clinical trial. Journal of Nuclear Medicine, 63(9), 1326-1333.
  3. Delpassand, E., Tworowska, I., Esfandiari, R., Torgue, J., Hurt, J. D., & Nunez, R. (2021). Phase I dose-escalation study of AlphaMedix for targeted-alpha-emitter therapy of PRRT-naive neuroendocrine patients.
  4. Delpassand, E. S., Ranganathan, D., Wagh, N., Shafie, A., Gaber, A., Abbasi, A., ... & Núñez, R. (2020). 64Cu-DOTATATE PET/CT for imaging patients with known or suspected somatostatin receptor–positive neuroendocrine tumors: Results of the first US prospective, reader-masked clinical trial. Journal of Nuclear Medicine, 61(6), 890-896.
  5. He, B., Frey, E., Sgouros, G., Ghaly, M., Tworowska, I., & Delpassand, E. (2019). Development and Validation of Methods for Quantitative In Vivo SPECT of Pb-212☆☆☆. Journal of Medical Imaging and Radiation Sciences, 50(4), S104.
  6. Tworowska, I., Delpassand, E. S., Bolek, L., Shanoon, F., Sgouros, G., Frey, E., ... & Torgue, J. (2019). Targeted alpha-emitter therapy of neuroendocrine Tumors using 212Pb-octreotate (AlphaMedix TM). Journal of Medical Imaging and Radiation Sciences, 50(4), S105-S106.
  7. Stallons, T. A. R., Saidi, A., Tworowska, I., Delpassand, E. S., & Torgue, J. J. (2019). Preclinical investigation of 212Pb-DOTAMTATE for peptide receptor radionuclide therapy in a neuroendocrine tumor model. Molecular cancer therapeutics, 18(5), 1012-1021.
  8. Delpassand, E., Tworowska, I., Shanoon, F., Nunez, R., Flores II, L., Muzammil, A., ... & Torgue, J. (2019). First clinical experience using targeted alpha-emitter therapy with 212Pb-DOTAMTATE (AlphaMedix TM) in patients with SSTR (+) neuroendocrine tumors.
  9. Hamiditabar, M., Ali, M., Roys, J., Wolin, E. M., O'Dorisio, T. M., Ranganathan, D., ... & Delpassand, E. S. (2017). Peptide receptor radionuclide therapy with 177Lu-octreotate in patients with somatostatin receptor expressing neuroendocrine tumors: six years' assessment. Clinical nuclear medicine, 42(6), 436-443.
  10. Hamiditabar, M., Ali, M., Bolek, L., Vahdati, G., Tworowska, I., & Delpassand, E. S. (2017). Safety and effectiveness of 177Lu-DOTATATE peptide receptor radionuclide therapy after regional hepatic embolization in patients with somatostatin-expressing neuroendocrine tumors. Clinical nuclear medicine, 42(11), 822-828.
  11. I. Tworowska, H. Saso, J. Sims-Mourtada, F. Mourtada, E. Delpassand and A. Azhdarinia, 68Ga-glucosamine analogs for PET imaging of cancer, J Nucl Med. 2009; (50) 376.
  12. I. Tworowska, H. Saso, J. Sims-Mourtada, A. Azhdarinia, Synthesis and properties of 68Ga-MPC-glucosamine conjugates for PET imaging of cancer, ACS National Meeting, 2009.
  13. Tworowska and E. ψ32, ψ39-modified anticodon arm of P. Nikonowicz, Base pairing within the Escherichia coli tRNAPhe , J. Am. Chem. Soc., 2006, 128 (49), 15570-15571.
  14. Jaroniec CP, Boisbouvier J, Tworowska I, Nikonowicz EP, Bax A, Accurate measurement of 15N-13C residual dipolar couplings in nucleic acids, J Biomol NMR., 2005, 31(3), 231-41.
  15. W. Dabkowski, A. Ozarek and I. Tworowska, Highly selective O-phosphitylation of amino alcohols using PIII reagents containing 4-nitro and 2,4-dinitroaryloxy leaving groups, New Journal of Chemistry, 2005, (29), 1396-1399.
  16. W. Dabkowski and I. Tworowska, Synthesis of phosphorofluoridates and phosphorofluorido-thioates via phosphoramidite approach, Org. Biomol. Chemistry, 2005, 3, 866-874.
  17. J. Cabello-Villegas, I. Tworowska and E. P. Nikonowicz, Metal Ion Stabilization of the U-turn of the A37 N6-dimethylally-Modified Anticodon Stem Loop of Escherichia coli tRNAPhe, Biochemistry 2004, 43, 55-56.
  18. Tworowska, W. Dabkowski and J. Michalski, The Phosphorofluoroamidite Aproach to Mixed Phosphites, J. Organometalic Chem. 2002, 643-644, 490-493.
  19. Tworowska, W. Dabkowski and J. Michalski, Synthesis of P-Fluorodithioacids of Phosphorus and their Synthetic Application, Phosphorus, Sulfur and Silicon, 2002, 177, 1855-1858.
  20. W. Dabkowski and I. Tworowska Synthesis of Phosphorofluoridates and Phosphorofluorido-thioates via the Phosphoramidite Approach., J. Chem. Soc., Perkin Trans. 1, 2001, 2462-2469.
  21. Tworowska, W. Dabkowski, and J. Michalski, Novel Synthesis of Tri- and Tetra-coordinate Phosphorus Compounds Containing the P-trifluoromethyl Group by Nucleophilic Trifluoromethylation of the Corresponding P-Fluoro Systems., Angew. Chem. Int. Ed. 2001 40(15), 2898-2990.
  22. W. Dabkowski, I. Tworowska, J. Michalski, F. Cramer, New Efficient Synthesis of Thymidine Cyclic 3', 5'-Phosphorofluoridate and Its Sulfur Analogue via the Phosphoroamidite Route, Nucleosides & Nucleotides, 2000, 19 (10&12), 1779-1785.
  23. W. Dabkowski, I. Tworowska, J. Michalski, F. Cramer, 2, 4-Dinitrophenol: a Novel Activating Reagent in Nucleotide Synthesis via the Phosphoramidite Route. Design of New Effective Phosphitylating Reagents., Tetrahedron Lett., 2000, 41, 7535-7539.
  24. W. Dabkowski, I. Tworowska, E. Poniatowska, J. Michalski, F. Cramer, Novel Unique Activating Reagents in Synthesis of Biophosphates via Phosphoroamidite Route., Phosphorus, Sulfur and Silicon, 1999, 144-146, 109-112.
  25. W. Dabkowski, I. Tworowska, E. Poniatowska, J. Michalski, F. Cramer, New Phosphitylating Reagents Containing P-F Bond and Their Application in the Synthesis of P-Fluoro Nucleosidyl Phosphates, Thiophosphates and Selenophosphates, Nucleosides & Nucleotides, 1999, 18(6,7), 1247-1248.
  26. W. Dabkowski, I. Tworowska, New strategies for chemical synthesis of phosphorodithioates from 2'- or 3'- or 5'-thionucleosides, Nucleosides & Nucleotides, 1999 18(4, 5), 977-988.
  27. W. Dabkowski, M. Michalska, I. Tworowska, A Simple and Efficient Synthesis of Nucleotide containing 5’-S- or 3’-S-phosphorothioate Linkage., Nucleosides & Nucleotides, 1998, 9-11, 1635-1637.
  28. W. Dabkowski, I. Tworowska, J. Michalski, F. Cramer, Novel Unique Catalytic Activating Reagents in the Synthesis of Biophosphates via the phosphoramidite Route. Nucleosides & Nucleotides, 1998, 9-11, 1639-1644.
  29. W. Dabkowski, M. Michalska, I. Tworowska, Highly Efficient Synthesis of Phosphorodithioates Derived from 3’-Thiothymidine by Anhydro-ring Opening of 2,3’-Anhydro-5’-tritylthymidine with O,O-Disubstitued Phosphorothioic Acids., J. Chem. Soc., Chem. Commun., 1998, 427-428.
  30. W. Dabkowski, I. Tworowska, J. Michalski, F. Cramer, Trimethylchlorosilane: a novel activating reagent in nucleotide synthesis via the phosphoramidite route., J. Chem. Soc., Chem. Commun., 1997, 877-878.


Profile Details

https://scholar.google.com/citations?user=XTBu8LAAAAAJ&hl=en
https://orcid.org/0000-0002-1461-1801
https://www.researchgate.net/profile/Izabela-Tworowska

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