Dr. Jithesh Kottur
Department
of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, USA
Email: [email protected]
Qualifications
2017 Ph.D., Biotechnology, Regional
Centre for Biotechnology of Faridabad
2011 M.Sc., Biochemistry, Medical
Biochemistry Kannur University
2007 B.Sc., Biochemistry,
Botany and Microbiology, University of Mysore
Publications (Selected)
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Johnson, M.K., Kottur, J and Nair, D.T.
(2019) A polar filter in DNA polymerases prevents ribonucleotide incorporation
Nucleic Acids Res. 47, 10693-10705
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Kottur, J and Nair, D. T. (2018)
Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis
reaction. Nucleic Acids Res.46, 5875-5885.
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Kottur, J. and Nair, D.T. (2016)
Reactive Oxygen Species Play an Important Role in the Bactericidal Activity of
Quinolone Antibiotics. Angew Chem Int Ed Engl, 55, 2397-2400.
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Ghodke, P.P., Gore, K.R., Harikrishna,
S., Samanta, B., Kottur, J., Nair, D.T. and Pradeepkumar, P.I. (2016) The
N(2)-Furfuryl-deoxyguanosine Adduct Does Not Alter the Structure of B-DNA. J
Org Chem, 81, 502-511.
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Weinert, T., Olieric, V.,
Waltersperger, S., Panepucci, E., Chen, L., Zhang, H., Zhou, D., Rose, J.,
Ebihara, A., Kuramitsu, S., Kottur, J. et al. (2015) Fast native-SAD phasing
for routine macromolecular structure determination. Nature Methods, 12,
131-133.
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Kottur, J., Sharma, A., Gore, K.R.,
Narayanan, N., Samanta, B., Pradeepkumar, P.I. and Nair, D.T. (2015) Unique
structural features in DNA polymerase IV enable efficient bypass of the N2
adduct induced by the nitrofurazone antibiotic. Structure, 23, 56-67.
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Nair, D.T., Kottur, J. and Sharma, R.
(2015) A rescue act: Translesion DNA synthesis past N(2) -deoxyguanosine
adducts. IUBMB Life, 67, 564-574.
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Sharma, A., Kottur, J., Narayanan, N.
and Nair, D.T. (2013) A strategically located serine residue is critical for
the mutator activity of DNA polymerase IV from Escherichia coli. Nucleic acids
research, 41, 5104-5114.
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Khan M, Jithesh K. Expression and
purification of organic solvent stable lipase from soil metagenomic library.
World J Microbiol Biotechnol. 2012 Jun;28(6):2417-24. doi:
10.1007/s11274-012-1051-0. Epub 2012 Apr 7. PMID: 22806116.
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Nair DT, Kottur J, Sharma R. A rescue
act: Translesion DNA synthesis past N(2) -deoxyguanosine adducts. IUBMB Life.
2015 Jul;67(7):564-74. doi: 10.1002/iub.1403. Epub 2015 Jul 14. PMID: 26173005.
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Khan M, Jithesh K, Mookambikay R.
Cloning and characterization of two functionally diverse lipases from soil
metagenome. J Gen Appl Microbiol. 2013;59(1):21-31. doi: 10.2323/jgam.59.021.
PMID: 23518515.
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Nair DT, Kottur J, Sharma R. A rescue
act: Translesion DNA synthesis past N(2) -deoxyguanosine adducts. IUBMB Life.
2015 Jul;67(7):564-74. doi: 10.1002/iub.1403. Epub 2015 Jul 14. PMID: 26173005.
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Yu X, Li D, Kottur J, Shen Y, Kim HS,
Park KS, Tsai YH, Gong W, Wang J, Suzuki K, Parker J, Herring L, Kaniskan HÜ,
Cai L, Jain R, Liu J, Aggarwal AK, Wang GG, Jin J. A selective WDR5 degrader
inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl
Med. 2021 Sep 29;13(613):eabj1578. doi: 10.1126/scitranslmed.abj1578. Epub 2021
Sep 29. PMID: 34586829; PMCID: PMC8500670.
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Aggarwal A, Kottur J. High resolution
structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic
development. Res Sq [Preprint]. 2022 Mar 8:rs.3.rs-1370473. doi:
10.21203/rs.3.rs-1370473/v1. PMID: 35291302; PMCID: PMC8923114.
Personal Website:
https://scholar.google.com/citations?hl=en&user=ICHHFD0AAAAJ