Biography

Prof. Elisabetta Mantuano

Link University in Rome, Italy


Email: [email protected]


Qualifications

1998 Pharm.D., University of Pisa, Italy

2004 Visiting Research Scholar., College of Pharmacy and Health Sciences, Butler University, Indianapolis Indiana

2007 Postdoctoral Fellow., Department of Anesthesiology and Pathology, UCSD


Publications (Selected)

  1. Martellucci, S., Flütsch, A., Carter, M., Norimoto, M., Pizzo, D., Mantuano, E., ... & Campana, W. M. (2024). Cover Image, Volume 72, Issue 5. Glia, 72(5), c1-c1.
  2. Martellucci, S., Flütsch, A., Carter, M., Norimoto, M., Pizzo, D., Mantuano, E., ... & Campana, W. M. (2024). Axon‐derived PACSIN1 binds to the S chwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities. Glia, 72(5), 916-937.
  3. Azmoon, P., Mantuano, E., Poudel, B., Zampieri, C., & Gonias, S. L. (2023). LRP1 Triggers Pro-inflammatory Cell-signaling in Response to Extracellular Tau Independently of the NMDA Receptor. bioRxiv, 2023-10.
  4. Mantuano, E., Zampieri, C., Azmoon, P., Gunner, C. B., Heye, K. R., & Gonias, S. L. (2023). An LRP1-binding motif in cellular prion protein replicates cell-signaling activities of the full-length protein. JCI insight, 8(15), e170121.
  5. Gunner, C. B., Azmoon, P., Mantuano, E., Das, L., Zampieri, C., Pizzo, S. V., & Gonias, S. L. (2023). An antibody that targets cell‐surface glucose‐regulated protein‐78 inhibits expression of inflammatory cytokines and plasminogen activator inhibitors by macrophages. Journal of cellular biochemistry, 124(5), 743-752.
  6. Mantuano, E., Azmoon, P., Banki, M. A., Gunner, C. B., & Gonias, S. L. (2022). The LRP1/CD91 ligands, tissue-type plasminogen activator, α2-macroglobulin, and soluble cellular prion protein have distinct co-receptor requirements for activation of cell-signaling. Scientific Reports, 12(1), 17594.
  7. Mantuano, E., Azmoon, P., Banki, M. A., Sigurdson, C. J., Campana, W. M., & Gonias, S. L. (2022). A soluble PrPC derivative and membrane-anchored PrPC in extracellular vesicles attenuate innate immunity by engaging the NMDA-R/LRP1 receptor complex. The Journal of Immunology, 208(1), 85-96.
  8. Mantuano, E., Azmoon, P., Banki, M. A., Lam, M. S., Sigurdson, C. J., & Gonias, S. L. (2020). A soluble derivative of PrPC activates cell-signaling and regulates cell physiology through LRP1 and the NMDA receptor. Journal of Biological Chemistry, 295(41), 14178-14188.
  9. Martellucci, S., Manganelli, V., Santilli, F., Mei, C., Ferri, A., Mantuano, E., ... & Mattei, V. (2020). Neuritogenic signal pathway of tPA mediated by the multimolecular complex containing PrPC and LRP1 is dependent on lipid rafts. The FASEB Journal, 34(S1), 1-1.
  10. Pontecorvi, P., Banki, M. A., Zampieri, C., Zalfa, C., Azmoon, P., Kounnas, M. Z., ... & Mantuano, E. (2019). Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines. Journal of neuroinflammation, 16(1), 257.
  11. Das, L., Azmoon, P., Banki, M. A., Mantuano, E., & Gonias, S. L. (2019). Tissue-type plasminogen activator selectively inhibits multiple toll-like receptors in CSF-1-differentiated macrophages. PLoS One, 14(11), e0224738.
  12. Mattei, V., Manganelli, V., Martellucci, S., Capozzi, A., Mantuano, E., Longo, A., ... & Misasi, R. (2020). A multimolecular signaling complex including PrPC and LRP1 is strictly dependent on lipid rafts and is essential for the function of tissue plasminogen activator. Journal of neurochemistry, 152(4), 468-481.
  13. Zalfa, C., Azmoon, P., Mantuano, E., & Gonias, S. L. (2019). Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin. Journal of leukocyte biology, 105(4), 729-740.
  14. Gonias, S. L., Banki, M. A., Gilder, A. S., Azmoon, P., Campana, W. M., & Mantuano, E. (2018). PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology. Journal of Cell Science, 131(14), jcs217083.
  15. Gilder, A. S., Natali, L., Van Dyk, D. M., Zalfa, C., Banki, M. A., Pizzo, D. P., ... & Gonias, S. L. (2018). The urokinase receptor induces a mesenchymal gene expression signature in glioblastoma cells and promotes tumor cell survival in neurospheres. Scientific reports, 8(1), 2982.
  16. Mantuano E, Tasciotti V, Garofalo T, Sorice M, Misasi R, Mattei V. PrPC associates with a multimolecular complex including LRP1 and glycosphingolipids within lipid rafts. The FASEB Journal. 2014 vol. 28 no. 1 Supplement 601.1
  17. Gupta S, Hau AM, Beach JR, Harwalker J, Mantuano E, Gonias SL, Egelhoff TT, Hansel DE. Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion. PLoS One. 2013 Nov 27;8(11):e81081.
  18. Mantuano E, Lam MS, Gonias SL. LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissuetype plasminogen activator and myelin-associated glycoprotein. Journal of Biological Chemistry. 2013 Nov 22;288(47):34009-18
  19. Yamauchi K, Yamauchi T, Mantuano E, Murakami K, Henry K, Takahashi K, Campana WM . Low-Density Lipoprotein Receptor Related protein-1 (LRP1)-Dependent Cell Signaling Promotes Neurotrophic Activity in Embryonic Sensory Neurons. PLoS One. 2013 Sept; 8(9):e75497.
  20. Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ichikawa T, Feltri ML, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias SL, Campana WM. Schwann cell LRP1 regulates Remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. Journal of Neuroscience. 2013 Mar 27;33(13):5590-602.
  21. Stiles T, Dickendeshe T, Gaultier A, Fernandez-Castaneda A, Mantuano E, Giger RJ, Gonias SL. LDL Receptor-related Protein-1 is a sialic acid-independent receptor for myelin-associated glycoprotein (MAG) that functions in neurite outgrowth inhibition by MAG and CNS myelin. Journal of Cell Science. 2012 Nov 6
  22. Capozzi A, Mantuano E, Matarrese P, Saccomanni G, Manera C, Mattei V, Gambardella L, Malorni W, Sorice M, Misasi R. A new 4-phenyl-1,8-naphthyridine derivative affects carcinoma cell proliferation by impairing cell cycle progression and inducing apoptosis. Anti-Cancer Agents in Medicinal Chemistry. 2012. Jul 1;12(6):653-62
  23. Mantuano E, Henry K, Yamauchi T, Hiramatsu H, Yamauchi K, Sumihisa O, Jonathan HL, Gonias SL, Campana WM. The Unfolded Protein Response is a Major Mechanism by which LRP1 Regulates Schwann Cell Survival After Injury. Journal of Neuroscience. 2011. Sep 21;31(38):13376-13385.



Personal Website:

https://www.unilink.it/en/university/teaching-staff/elisabetta-mantuano
https://www.researchgate.net/profile/Elisabetta-Mantuano
https://www.linkedin.com/in/elisabetta-mantuano-pharmd-phd-78238353/
https://www.lji.org/news-events/news/post/la-jolla-institute-for-immunology-launches-new-international-research-partnership-with-link-campus-university/


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