Dr. Ramkumar Srinivasagan

Case Western Reserve University, USA

Research Associate

Email: [email protected]

Qualifications

2014 Ph.D., Bharathidasan University, India

2009 M.Sc., Anna University, India

2007 B.Sc., Bharathidasan University, India

Publications (Selected)

1. Wei, Z., Hao, C., Radeen, K. R., Srinivasagan, R., Chen, J. K., Sharma, S., ... & Fan, X. (2024). Prevention of age-related truncation of γ-glutamylcysteine ligase catalytic subunit (GCLC) delays cataract formation. Science Advances, 10(17), eadl1088.
2. Ramkumar, S., Jastrzebska, B., Montenegro, D., Sparrow, J. R., & von Lintig, J. (2024). Unraveling the mystery of ocular retinoid turnover: Insights from albino mice and the role of STRA6. Journal of Biological Chemistry, 300(3).
3. Thomas, L. D., Ramkumar, S., Golczak, M., & von Lintig, J. (2023). Genetic deletion of Bco2 and Isx establishes a golden mouse model for carotenoid research. Molecular Metabolism, 73, 101742.
4. Bandara, S., Moon, J., Ramkumar, S., & von Lintig, J. (2023). ASTER-B regulates mitochondrial carotenoid transport and homeostasis. Journal of Lipid Research, 64(5).
5. Moon, J., Ramkumar, S., & von Lintig, J. (2023). Genetic tuning of β-carotene oxygenase-1 activity rescues cone photoreceptor function in STRA6-deficient mice. Human molecular genetics, 32(5), 798-809.
6. Ramkumar, S., Parmar, V. M., Moon, J., Lee, C., Taylor, P. R., & von Lintig, J. (2022). Diabetes aggravates photoreceptor pathologies in a mouse model for ocular vitamin A deficiency. Antioxidants, 11(6), 1142.
7. Moon, J., Ramkumar, S., & von Lintig, J. (2022). Genetic dissection in mice reveals a dynamic crosstalk between the delivery pathways of vitamin A. Journal of Lipid Research, 63(6).
8. Wei, Z., Hao, C., Srinivasagan, R., Wu, H., Chen, J. K., & Fan, X. (2021). Mitotic activation around wound edges and epithelialization repair in UVB-induced capsular cataracts. Investigative Ophthalmology & Visual Science, 62(15), 29-29.
9. Schlegel, D. K., Ramkumar, S., von Lintig, J., & Neuhauss, S. C. (2021). Disturbed retinoid metabolism upon loss of rlbp1a impairs cone function and leads to subretinal lipid deposits and photoreceptor degeneration in the zebrafish retina. Elife, 10, e71473.
10. Ramkumar, S., Parmar, V. M., Samuels, I., Berger, N. A., Jastrzebska, B., & von Lintig, J. (2022). The vitamin A transporter STRA6 adjusts the stoichiometry of chromophore and opsins in visual pigment synthesis and recycling. Human molecular genetics, 31(4), 548-560.
11. Wei, Z., Hao, C., Huangfu, J., Srinivasagan, R., Zhang, X., & Fan, X. (2021). Aging lens epithelium is susceptible to ferroptosis. Free Radical Biology and Medicine, 167, 94-108.
12. Bandara, S., Thomas, L. D., Ramkumar, S., Khadka, N., Kiser, P. D., Golczak, M., & von Lintig, J. (2021). The structural and biochemical basis of apocarotenoid processing by β-carotene oxygenase-2. ACS chemical biology, 16(3), 480-490.
13. Petrosino, J. M., Longenecker, J. Z., Ramkumar, S., Xu, X., Dorn, L. E., Bratasz, A., ... & Accornero, F. (2021). Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1. The Journal of Clinical Investigation, 131(4).
14. Ramkumar, S., Moon, J., Golczak, M., & von Lintig, J. (2021). LRAT coordinates the negative-feedback regulation of intestinal retinoid biosynthesis from β-carotene. Journal of Lipid Research, 62, 100055.
15. Thomas, L. D., Bandara, S., Parmar, V. M., Srinivasagan, R., Khadka, N., Golczak, M., ... & von Lintig, J. (2020). The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids. Journal of Biological Chemistry, 295(46), 15553-15565.
16. Wu, L., Lyu, Y., Srinivasagan, R., Wu, J., Ojo, B., Tang, M., ... & Lin, D. (2020). Astaxanthin-shifted gut microbiota is associated with inflammation and metabolic homeostasis in mice. The Journal of Nutrition, 150(10), 2687-2698.

Profile Details

https://orcid.org/0000-0002-2542-1501

https://www.linkedin.com/in/ramkumar-srinivasagan-279180111/

https://www.researchgate.net/profile/Ramkumar-Srinivasagan