Prof. Sheng-Xiang Lin

Oncology and Molecular Endocrinology Research Center, Laval University Medical Center, Quebec, Canada

Email: [email protected]

Qualifications:

1982-1984 Doctorat d'État Institut de Biologie Moléculaire et Cellulaire: Strasbourg, Alsace, FR

1979-1982 Ph. D Institut de Biologie Moléculaire et Cellulaire: Strasbourg, Alsace, France

1979 M. Sc. Institute of Biochemistry and Cell Biology: Shanghai, Shanghai, China

Publications:

1. Wu, X., Xia, H., Li, W., Chen, J., Zhou, L., Zhang, Q., ... & Lin, S. X. (2024). Exploring the efficacious subfractions and underlying mechanisms of Herba Siegesbeckiae against myocardial ischemia/reperfusion injury via the UCHL5/NLRP3 pathway. Acta Materia Medica, 3(4), 365-382.
2. Zhang, W., & Lin, S. X. (2023). Search of novel small molecule inhibitors for the main protease of SARS-CoV-2. Viruses, 15(2), 580.
3. Sang, X., Belmessabih, N., Wang, R., Stephen, P., & Lin, S. X. (2022). CRIF1-CDK2 interface inhibitors enhance taxol inhibition of the lethal triple-negative breast cancer. Cancers, 14(4), 989.
4. Zhang, W. F., Stephen, P., Thériault, J. F., Wang, R., & Lin, S. X. (2020). Novel coronavirus polymerase and nucleotidyl-transferase structures: potential to target new outbreaks. The journal of physical chemistry letters, 11(11), 4430-4435.
5. Liu, W. J., Zhao, G., Zhang, C. Y., Yang, C. Q., Zeng, X. B., Li, J., ... & Lin, S. X. (2020). Comparison of the roles of estrogens and androgens in breast cancer and prostate cancer. Journal of cellular biochemistry, 121(4), 2756-2769.
6. Li, T., Stephen, P., Zhu, D. W., Shi, R., & Lin, S. X. (2019). Crystal structures of human 17β‐hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+ reveal the mechanism of substrate inhibition. The FEBS journal, 286(11), 2155-2166.
7. Stephen, P., Baz, M., Boivin, G., & Lin, S. X. (2016). Structural insight into NS5 of Zika virus leading to the discovery of MTase inhibitors. Journal of the American Chemical Society, 138(50), 16212-16215.
8. Zhang, C. Y., Wang, W. Q., Chen, J., & Lin, S. X. (2015). Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology, 150, 24-34.
9. Adjo Aka, J., & Lin, S. X. (2012). Comparison of functional proteomic analyses of human breast cancer cell lines T47D and MCF7. PloS one, 7(2), e31532.
10. Lin, S. X., Chen, J., Mazumdar, M., Poirier, D., Wang, C., Azzi, A., & Zhou, M. (2010). Molecular therapy of breast cancer: progress and future directions. Nature Reviews Endocrinology, 6(9), 485-493.
11. Aka, J. A., Mazumdar, M., & Lin, S. X. (2009). Reductive 17β-hydroxysteroid dehydrogenases in the sulfatase pathway: critical in the cell proliferation of breast cancer. Molecular and cellular endocrinology, 301(1-2), 183-190.
12. Mazumdar, M., Fournier, D., Zhu, D. W., Cadot, C., Poirier, D., & Lin, S. X. (2009). Binary and ternary crystal structure analyses of a novel inhibitor with 17β-HSD type 1: a lead compound for breast cancer therapy. Biochemical Journal, 424(3), 357-366.
13. Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S. X., & Pelletier, G. (2003). Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone. Endocrine reviews, 24(2), 152-182.
14. Labrie, F., Lin, S. X., Simard, J., & Labrie, C. (2000). Role of 17β-hydroxysteroid dehydrogenases in sex steroid formation in peripheral intracrine tissues. Trends in Endocrinology & Metabolism, 11(10), 421-427.

Profile Details:

https://www.crchudequebec.ulaval.ca/en/researcher/sheng-xiang-lin/
https://scholar.google.com/citations?user=F7ZJctkAAAAJ&hl=en&oi=ao
https://orcid.org/0000-0001-9149-375X
https://sciprofiles.com/profile/346322