Prof. Sheng-Xiang Lin

Laval University Medical Center, Quebec, Canada. 

Email: [email protected]

Qualifications
1982-1984 Doctorat d'État Institut de Biologie Moléculaire et Cellulaire: Strasbourg, Alsace, FR
1979-1982 Ph. D Institut de Biologie Moléculaire et Cellulaire: Strasbourg, Alsace, France
1979 M. Sc. Institute of Biochemistry and Cell Biology: Shanghai, Shanghai, China

1. Wang, R., Wang, X., Su, P., et al. (2026). Developing Potential Endocrine Therapy Controlling Estradiol and DHT by Targeting 17β-HSD7 Against ER plus Breast Cancer. Cells, 15(15), Article 1345.
2. Sancéau, J.-Y., Maltais, R., Zhou, M., et al. (2024). Synthesis and characterization of targeted 17β-hydroxysteroid dehydrogenase type 7 inhibitors. The Journal of Steroid Biochemistry and Molecular Biology, 242, Article 106544.
3. Iqbal, S., & Lin, S.-X. (2023). Deep Drug Discovery of Mac Domain of SARS-CoV-2 (WT) Spike Inhibitors: Using Experimental ACE2 Inhibition TR-FRET Assay, Screening, Molecular Dynamic Simulations and Free Energy Calculations. Bioengineering, 10(8), Article 961.
4. Zhang, W., & Lin, S.-X. (2023). Search of Novel Small Molecule Inhibitors for the Main Protease of SARS-CoV-2. Viruses, 15(2), Article 580.
5. Li, T., Song, X., Stephen, P., et al. (2023). New insights into the substrate inhibition of human 17ss-hydroxysteroid dehydrogenase type 1. The Journal of Steroid Biochemistry and Molecular Biology, 228, Article 106246.
6. Sang, X., Belmessabih, N., Wang, R., et al. (2022). CRIF1-CDK2 Interface Inhibitors Enhance Taxol Inhibition of the Lethal Triple-Negative Breast Cancer. Cancers, 14(4), Article 989.
7. Thériault, J.-F., Poirier, D., & Lin, S.-X. (2021). The multi-specific human 17 beta-hydroxysteroid dehydrogenase type 7: Non-competitive inhibitors can target different catalyses to facilitate breast cancer treatment. The Journal of Steroid Biochemistry and Molecular Biology, 214, Article 105963.
8. Wang, R., Stephen, P., Tao, Y., et al. (2021). Human endeavor for anti-SARS-CoV-2 pharmacotherapy: A major strategy to fight the pandemic. Biomedicine & Pharmacotherapy, 137, Article 111232.
9. Wang, R., Li, T., Li, G., et al. (2021). An unprecedented endocrine target for ovarian cancer: inhibiting 17β-HSD7 supresses cancer cell proliferation and arrests G2/M cycle. American Journal of Cancer Research, 11(11), 5358–5367.
10. Audet-Walsh, É., Wang, X. Q., & Lin, S.-X. (2020). Using Omics to better understand steroid biosynthesis, metabolism, and functions. The Journal of Steroid Biochemistry and Molecular Biology, 202, Article 105686.
11. Zhang, W.-F., Stephen, P., Thériault, J.-F., et al. (2020). Novel Coronavirus Polymerase and Nucleotidyl-Transferase Structures: Potential to Target New Outbreaks. The Journal of Physical Chemistry Letters, 11(11), 4430–4435.
12. Zhang, W.-F., Li, T., & Lin, S.-X. (2020). Meta-Analysis of steroid-converting enzymes and related receptors in prostate cancer suggesting novel combined therapies. The Journal of Steroid Biochemistry and Molecular Biology, 198, Article 105559.
13. Li, T., Zhang, W., & Lin, S.-X. (2020). Steroid enzyme and receptor expression and regulations in breast tumor samples - A statistical evaluation of public data. The Journal of Steroid Biochemistry and Molecular Biology, 196, Article 105494.
14. Zhang, C.-Y., Calvo, E.-L., Yang, C.-Q., et al. (2019). Transcriptome of 17β-hydroxysteroid dehydrogenase type 2 plays both hormone-dependent and hormone-independent roles in MCF-7 breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology, 195, Article 105471.
15. Liu, W.-J., Zhao, G., Zhang, C.-Y., et al. (2020). Comparison of the roles of estrogens and androgens in breast cancer and prostate cancer. Journal of Cellular Biochemistry, 121(4), 2756–2769.
16. Sang, X., Han, H., Li, T., et al. (2019). Mutual regulations and breast cancer cell control by steroidogenic enzymes: Dual sex-hormone receptor modulation upon 17β-HSD7 inhibition. The Journal of Steroid Biochemistry and Molecular Biology, 193, Article 105411.
17. Li, T., Stephen, P., Zhu, D.-W., et al. (2019). Crystal structures of human 17β-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+ reveal the mechanism of substrate inhibition. The FEBS Journal, 286(11), 2155–2166.
18. Tchernof, A., Lin, S. X., Van, L. T., et al. (2019). The Passing of Dr. Fernand Labrie (1937-2019): The legacy of excellence in science Obituary. The Journal of Steroid Biochemistry and Molecular Biology, 189, 63–64.
19. Thériault, J.-F., & Lin, S.-X. (2019). The dual sex hormone specificity for human reductive 17β-hydroxysteroid dehydrogenase type 7: Synergistic function in estrogen and androgen control. The Journal of Steroid Biochemistry and Molecular Biology, 186, 61–65.
20. Ran, Q., Xiang, Y., Stephen, P., et al. (2019). CRIF1-CDK2 Interface Inhibitors: An Unprecedented Strategy for Modulation of Cell Radiosensitivity. Journal of the American Chemical Society, 141(4), 1420–1424.
21. Li, F., Zhu, Z., Xue, M., et al. (2019). siRNA-based breast cancer therapy by suppressing 17β-hydroxysteroid dehydrogenase type I in an optimized xenograft cell and molecular biology model in vivo. Drug Design, Development and Therapy, 13, 757–766.
22. Sang, X., Han, H., Poirier, D., et al. (2018). Steroid sulfatase inhibition success and limitation in breast cancer clinical assays: An underlying mechanism. The Journal of Steroid Biochemistry and Molecular Biology, 183, 80–93.

Profile Details
https://www.crchudequebec.ulaval.ca/en/researcher/sheng-xiang-lin/
https://scholar.google.com/citations?user=F7ZJctkAAAAJ&hl=fr
https://www.researchgate.net/scientific-contributions/Shengxiang-Lin-2107122335

WOS ResearcherID: JUR-8551-2023