Dr. Kejie Yin

Department of Neurology

University of Pittsburgh School of Medicine, USA

Email: [email protected]

Qualifications

1998  Ph.D., Shanghai Medical University, Shanghai, China

1990  M.S., Nanjing Medical University, Nanjing, China

1983  M.D., Yangzhou University Medical College, Yangzhou, China

Publications (Selected)

1. Xiong, T., Qiu, N., Ni, A., Xu, X., Sun, P., Li, S., & Yin, K. J. (2025). Nitro‐oleic acid activation of endothelial PPARγ signaling pathway alleviates neurovascular injury and improves functional outcomes in ischemic stroke. Brain Pathology, e70037.
2. Sun, P., Xu, Y., Xiong, T., Li, S., Qiu, N., Zhou, C., ... & Yin, K. J. (2025). Genetic deletion of microRNA-15a/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke. Angiogenesis, 28(3), 35.
3. Zhou, C., Li, S., Qiu, N., Sun, P., Hamblin, M. H., Dixon, C. E., ... & Yin, K. J. (2024). Loss of microRNA-15a/16-1 function promotes neuropathological and functional recovery in experimental traumatic brain injury. JCI insight, 9(12), e178650.
4. Li, S., Qiu, N., Ni, A., Hamblin, M. H., & Yin, K. J. (2024). Role of regulatory non-coding RNAs in traumatic brain injury. Neurochemistry international, 172, 105643.
5. Pu, H., Wang, Y., Yang, T., Leak, R. K., Stetler, R. A., Yu, F., ... & Chen, J. (2023). Interleukin-4 mitigates anxiety-like behavior and loss of neurons and fiber tracts in limbic structures in a microglial PPARγ-dependent manner after traumatic brain injury. Neurobiology of Disease, 180, 106078.
6. Yin, K. J., Hamblin, M. H., & Lee, J. P. (2023). Editorial of special issue: Pharmacological, gene, and cell-based therapeutics targeting early or late neurodegenerative and neurovascular diseases. Experimental neurology, 361, 114297.
7. Sun, P., Hamblin, M. H., & Yin, K. J. (2022). Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders. Fluids and Barriers of the CNS, 19(1), 27.
8. Zhou, C., Su, M., Sun, P., Tang, X., & Yin, K. J. (2021). Nitro-oleic acid-mediated blood-brain barrier protection reduces ischemic brain injury. Experimental Neurology, 346, 113861.
9. Sun, P., Ma, F., Xu, Y., Zhou, C., Stetler, R. A., & Yin, K. J. (2021). Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway. Journal of Cerebral Blood Flow & Metabolism, 41(10), 2725-2742.
10. Das, S., Shah, R., Dimmeler, S., Freedman, J. E., Holley, C., Lee, J. M., ... & American Heart Association Council on Genomic and Precision Medicine; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology. (2020). Noncoding RNAs in cardiovascular disease: current knowledge, tools and technologies for investigation, and future directions: a scientific statement from the american heart association. Circulation: Genomic and Precision Medicine, 13(4), e000062.
11. Sun, P., Zhang, K., Hassan, S. H., Zhang, X., Tang, X., Pu, H., ... & Yin, K. J. (2020). Endothelium-targeted deletion of microRNA-15a/16-1 promotes poststroke angiogenesis and improves long-term neurological recovery. Circulation research, 126(8), 1040-1057.
12. Ma, F., Sun, P., Zhang, X., Hamblin, M. H., & Yin, K. J. (2020). Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke. Science signaling, 13(626), eaay5686.
13. Ma, F., Zhang, X., & Yin, K. J. (2020). MicroRNAs in central nervous system diseases: A prospective role in regulating blood-brain barrier integrity. Experimental neurology, 323, 113094.
14. Zhang, X., Hamblin, M. H., & Yin, K. J. (2019). Noncoding RNAs and stroke. The Neuroscientist, 25(1), 22-26.
15. Sun, P., Liu, D. Z., Jickling, G. C., Sharp, F. R., & Yin, K. J. (2018). MicroRNA-based therapeutics in central nervous system injuries. Journal of Cerebral Blood Flow & Metabolism, 38(7), 1125-1148.
16. Cai, W., Yang, T., Liu, H., Han, L., Zhang, K., Hu, X., ... & Chen, J. (2018). Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair. Progress in neurobiology, 163, 27-58.
17. Zhang, X., Hamblin, M. H., & Yin, K. J. (2017). The long noncoding RNA Malat1: Its physiological and pathophysiological functions. RNA biology, 14(12), 1705-1714.
18. Zhang, X., Tang, X., Liu, K., Hamblin, M. H., & Yin, K. J. (2017). Long noncoding RNA Malat1 regulates cerebrovascular pathologies in ischemic stroke. Journal of Neuroscience, 37(7), 1797-1806.
19. Wang, Q., Navitskaya, S., Chakravarthy, H., Huang, C., Kady, N., Lydic, T. A., ... & Busik, J. V. (2016). Dual anti-inflammatory and anti-angiogenic action of miR-15a in diabetic retinopathy. EBioMedicine, 11, 138-150.
20. Zhang, J., Yuan, L., Zhang, X., Hamblin, M. H., Zhu, T., Meng, F., ... & Yin, K. J. (2016). Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia. Experimental neurology, 277, 162-170.
21. Yin, K. J., Hamblin, M., & Eugene Chen, Y. (2015). Angiogenesis-regulating microRNAs and ischemic stroke. Current vascular pharmacology, 13(3), 352-365.
22. Yin, K. J., Hamblin, M., Fan, Y., Zhang, J., & Chen, Y. E. (2015). Krüpple-like factors in the central nervous system: novel mediators in stroke. Metabolic brain disease, 30(2), 401-410.
23. Yin, K. J., Hamblin, M., & Chen, Y. E. (2014). Non-coding RNAs in cerebral endothelial pathophysiology: emerging roles in stroke. Neurochemistry international, 77, 9-16.
24. Yin, K. J., Fan, Y., Hamblin, M., Zhang, J., Zhu, T., Li, S., ... & Chen, Y. E. (2013). KLF11 mediates PPARγ cerebrovascular protection in ischaemic stroke. Brain, 136(4), 1274-1287.

Profile Details

https://www.neurology.pitt.edu/people/kejie-yin-md-phd

https://scholar.google.com/citations?hl=en&user=IKlQdcMAAAAJ&view_op=list_works&sortby=pubdate

https://pubmed.ncbi.nlm.nih.gov/?term=Yin+KJ&cauthor_id=40526299