Biography

Dr. Cuihua Wang

Center for Systems Biology

Harvard Medical School,USA

Research Fellow


Email: [email protected]


Qualifications

2006 Ph.D., Peking University, Organic Chemistry

2000 B.Sc., Qingdao University, Chemical Engineering


Publications (Selected)

  1. Wang C, Jalali Motlagh N, Wojtkiewicz GR, Yang H, Kim HH, Chen JW. A specific and adaptable approach to track CD206+ macrophages by molecular MRI and fluorescence imaging. Theranostics. 2025 Jan 1;15(3):1094-1109. doi: 10.7150/thno.96488. PMID: 39776805; PMCID: PMC11700851.
  2. Motlagh NJ, Wang C, Kim HH, Jun Y, Kim D, Lee S, Chen JW. Aging Intensifies Myeloperoxidase Activity after Ischemic Stroke. Aging Dis. 2024 Aug 30;15(6):2650-2664. doi: 10.14336/AD.2023.1640. PMID: 39325942; PMCID: PMC11567251.
  3. Zeller, M. W. G., Wang, C., Keliher, E. J., Wojtkiewicz, G. R., Aguirre, A., Maresca, K., Su, C., Buckbinder, L., Wang, J., Nahrendorf, M., & Chen, J. W. (2023). Myeloperoxidase PET Imaging Tracks Intracellular and Extracellular Treatment Changes in Experimental Myocardial Infarction. International Journal of Molecular Sciences, 24(6), 5704. https://doi.org/10.3390/ijms24065704
  4. Li J-H, Forghani R, Bure L, et al. Molecular immuno-imaging improves tumor detection in head and neck cancer. FASEB J. 2022; 36:e22092. doi:10.1096/fj.202100864R
  5. Jalali Motlagh, N., Wang, C., Kuellenberg, E. G., Wojtkiewicz, G. R., Schmidt, S., & Chen, J. W. (2021). D-Mannose Slows Glioma Growth by Modulating Myeloperoxidase Activity. Cancers, 13(24), 6360. https://doi.org/10.3390/cancers13246360
  6. J. Wang,N. Jalali Motlagh,C. Wang,G.R. Wojtkiewicz,S. Schmidt,C. Chau,R. Narsimhan,E.G. Kuellenberg,C. Zhu,J. Linnoila,Z. Yao,& J.W. Chen,  d-mannose suppresses oxidative response and blocks phagocytosis in experimental neuroinflammation, Proc. Natl. Acad. Sci. U.S.A. 118 (44) e2107663118, https://doi.org/10.1073/pnas.2107663118 (2021).
  7. Wang C, Pulli B, Jalali Motlagh N, Li A, Wojtkiewicz GR, Schmidt SP, Wu Y, Zeller MWG, Chen JW. A versatile imaging platform with fluorescence and CT imaging capabilities that detects myeloperoxidase activity and inflammation at different scales. Theranostics. 2019 Oct 12;9(25):7525-7536. doi: 10.7150/thno.36264. PMID: 31695784; PMCID: PMC6831463.
  8. Anning Li, Yue Wu, Benjamin Pulli, Gregory R. Wojtkiewicz, Yoshiko Iwamoto, Cuihua Wang, Jing-Hui Li, Muhammad Ali, Xiaoyuan Feng, Zhenwei Yao, and John W. Chen. (2019). Myeloperoxidase Molecular MRI Reveals Synergistic Combination Therapy in Murine Experimental Autoimmune Neuroinflammation. Radiology 2019 293:1, 158-165
  9. C. Wang, E. Keliher, M.W.G. Zeller, G.R. Wojtkiewicz, A.D. Aguirre, L. Buckbinder, H. Kim, J. Chen, K. Maresca, M.S. Ahmed, N.J. Motlagh, M. Nahrendorf, & J.W. Chen, An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo, Proc. Natl. Acad. Sci. U.S.A. 116 (24) 11966-11971, https://doi.org/10.1073/pnas.1818434116 (2019).
  10. Angelika Hoffmann, Johannes Pfeil, Ann-Kristin Mueller, Jessica Jin, Katrin Deumelandt, Xavier Helluy, Cuihua Wang, Sabine Heiland, Michael Platten, John W. Chen, Martin Bendszus, and Michael O. Breckwoldt. (2019). MRI of Iron Oxide Nanoparticles and Myeloperoxidase Activity Links Inflammation to Brain Edema in Experimental Cerebral Malaria. Radiology 2019 290:2, 359-367
  11. Benjamin Pulli, Gregory Wojtkiewicz, Yoshiko Iwamoto, Muhammad Ali, Matthias W. Zeller, Lionel Bure, Cuihua Wang, Yuri Choi, Ricard Masia, Alex R. Guimaraes, Kathleen E. Corey, and John W. Chen. (2017). Molecular MR Imaging of Myeloperoxidase Distinguishes Steatosis from Steatohepatitis in Nonalcoholic Fatty Liver Disease. Radiology 2017 284:2, 390-400
  12. Keliher, E., Ye, YX., Wojtkiewicz, G. et al. Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nat Commun 8, 14064 (2017). https://doi.org/10.1038/ncomms14064
  13. Li, A., Wu, Y., Linnoila, J. et al. Surface biotinylation of cytotoxic T lymphocytes for in vivo tracking of tumor immunotherapy in murine models. Cancer Immunol Immunother 65, 1545–1554 (2016). https://doi.org/10.1007/s00262-016-1911-9
  14. Yinian Zhang, Daniel P. Seeburg, Benjamin Pulli, Gregory R. Wojtkiewicz, Lionel Bure, Wendy Atkinson, Stefan Schob, Yoshiko Iwamoto, Muhammad Ali, Wei Zhang, Elisenda Rodriguez, Andrew Milewski, Edmund J. Keliher, Cuihua Wang, Yawen Pan, Filip K. Swirski, and John W. Chen. (2016). Myeloperoxidase Nuclear Imaging for Epileptogenesis. Radiology 2016 278:3, 822-830
  15. Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, et al. (2014) Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production. PLoS ONE 9(2): e87877. https://doi.org/10.1371/journal.pone.0087877
  16. Wang, C.; Ashton, T.D.; Gustafson, A.; Bland, N.D. Ochiana, S.O.; Campbell, R.K.; Pollastri, M.P. Synthesis and Evaluation of Human Phosphodiesterases (PDE5) Inhibitor Analogs as Trypanosomal PDE Inhibitors. 1. Sildenafil Analogs.Bioorg. Med. Chem. Lett. 2012, 22(7), 2579-81.
  17. Barluenga, S., Fontaine, J.-G., Wang, C., Aouadi, K., Chen, R., Beebe, K., Neckers, L. and Winssinger, N. (2009), Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights. ChemBioChem, 10: 2753-2759. https://doi.org/10.1002/cbic.200900494
  18. Barluenga S, Wang C, Fontaine JG, Aouadi K, Beebe K, Tsutsumi S, Neckers L, Winssinger N. Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor. Angew Chem Int Ed Engl. 2008;47(23):4432-5. doi: 10.1002/anie.200800233. PMID: 18435518; PMCID: PMC2701509.
  19. Mingji, D., Liang, B., Wang, C., You, Z., Xiang, J., Dong, G., Chen, J. and Yang, Z. (2004), A Novel Thiourea Ligand Applied in the Pd-Catalyzed Heck, Suzuki and Suzuki Carbonylative Reactions. Adv. Synth. Catal., 346: 1669-1673. https://doi.org/10.1002/adsc.200404165
  20. Dai, M., Wang, C., Dong, G., Xiang, J., Luo, T., Liang, B., Chen, J. and Yang, Z. (2003), Development of Thiourea-Based Ligands for the Palladium-Catalyzed Bis(methoxycarbonylation) of Terminal Olefins. Eur. J. Org. Chem., 2003: 4346-4348. https://doi.org/10.1002/ejoc.200300543

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